An Integrated Synthesis-Purification System to Accelerate the Generation of Compounds in Pharmaceutical Discovery

We report herein a high-throughput integrated synthesis—purification platform termed SWIFT (synthesis with integrated-flow technology) and processes that accelerate the rate at which validated small-molecule organic compounds are generated. A segmented-flow synthesizer was integrated to a preparative HPLC-MS, where each reaction product was purified immediately upon reaction completion. Further, automated structure-validation processes accelerate the rate at which drug discovery candidates are available for biological screening.

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