Chemiluminescence as diagnostic tool. A review.

The principles of chemiluminescence and its applications as diagnostic tool are reviewed. After an introduction to the theoretical aspects of luminescence and energy transfer, the different classes of chemiluminogenic labels including luminol, acridinium compounds, coelenterazine and analogues, dioxetanes, systems based on peroxyoxalic acid and their derivatives are described emphasizing the molecules which best fulfil the requirements of today's clinical chemistry. Applications of chemiluminescence and enhanced chemiluminescence to immunoassays, receptor assays, DNA probes, biosensors and oxygen metabolism are discussed as well as the role of enzymes in the selectivity and the sensitivity of these reactions.

[1]  C. Akdis,et al.  Chemiluminescent and enzyme-linked immuno assays for sensitive detection of human IFN-gamma. , 1994, Journal of immunoassay.

[2]  G. Cilento,et al.  Characterization of myeloid or lymphoid acute leukemia by a chemiluminescence assay. Comparison with immunocytochemistry using an antimyeloperoxidase antibody. , 1993, Acta haematologica.

[3]  M. Lucas,et al.  Coelenterazine is a superoxide anion-sensitive chemiluminescent probe: its usefulness in the assay of respiratory burst in neutrophils. , 1992, Analytical biochemistry.

[4]  R D Schmid,et al.  On-line determination of glucose concentration throughout animal cell cultures based on chemiluminescent detection of hydrogen peroxide coupled with flow-injection analysis. , 1991, Journal of biotechnology.

[5]  H. Köster,et al.  Applications of dioxetane chemiluminescent probes to molecular biology , 1990 .

[6]  F. Bernardi,et al.  Chemiluminescent Decomposition of 1,2-Dioxetanes: An MC-SCF/MP2 Study with VB Analysis , 1991 .

[7]  K. Nakashima,et al.  Peroxyoxalate chemiluminescent assay for oxidase activities based on detecting enzymatically formed hydrogen peroxide. , 1995, Journal of bioluminescence and chemiluminescence.

[8]  M. M. Rauhut,et al.  Chemiluminescence from reactions of electronegatively substituted aryl oxalates with hydrogen peroxide and fluorescent compounds , 1967 .

[9]  M. Zoratti,et al.  Synthesis of coelenterazine. , 1996, Analytical Biochemistry.

[10]  S. Mcmillan,et al.  Myeloperoxidase deficiency in a patient with rheumatoid arthritis: oxygenation and radical activity by phagocytic cells. , 1993, British journal of rheumatology.

[11]  I. Cree,et al.  Antibiotic effects on phagocyte chemiluminescence in vitro , 1995, International journal of clinical & laboratory research.

[12]  TJ Wu,et al.  Parathyroid-hormone-related peptide immunochemiluminometric assay. Developed with polyclonal antisera produced from a single animal. , 1997, Annals of Clinical and Laboratory Science.

[13]  J. Bergman,et al.  Effect of iron chelates on luminol chemiluminescence in the presence of xanthine oxidase , 1989 .

[14]  F. Silveri,et al.  Stimulated chemiluminescence of polymorphonuclear leukocytes in rheumatoid arthritis: in vivo enhancement by auranofin. , 1988, Zeitschrift fur Rheumatologie.

[15]  Loïc J. Blum,et al.  Enhancement of the response of a lactate oxidase/peroxidase-based fiberoptic sensor by compartmentalization of the enzyme layer , 1994 .

[16]  F. Ursini,et al.  Measurement of lipid hydroperoxides in plasma lipoproteins by a new highly-sensitive 'single photon counting' luminometer. , 1995, Biochimica et biophysica acta.

[17]  B. Ames,et al.  Evaluation of an isoluminol chemiluminescence assay for the detection of hydroperoxides in human blood plasma. , 1988, Analytical biochemistry.

[18]  K. Adeli,et al.  A competitive chemiluminescent immunoassay for the sensitive measurement of apolipoprotein B100. , 1995, Clinical biochemistry.

[19]  R. S. Handley,et al.  Chemical and enzymatic triggering of 1,2-dioxetanes. 2: fluoride-induced chemiluminescence from tert-butyldimethylsilyloxy-substituted dioxetanes , 1987 .

[20]  L J Kricka,et al.  Chemiluminescent assay of alkaline phosphatase applied in an ultrasensitive enzyme immunoassay of thyrotropin. , 1989, Clinical chemistry.

[21]  A. Roda,et al.  Detection of parvovirus B19 DNA in bone marrow cells by chemiluminescence in situ hybridization , 1996, Journal of clinical microbiology.

[22]  J. Lancaster.  Bioluminescence and chemiluminescence. Current status: Edited by Philip E. Stanley and Larry J. Kricka. Pp. 570. Wiley, Chichester. 1991. £80.00 , 1991 .

[23]  M. Tsukamoto,et al.  The antioxidant action of 2‐methyl‐6‐(p‐methoxyphenyl)‐3,7‐dihydroimidazo[1,2‐α]pyrazin‐3‐one (MCLA), a chemiluminescence probe to detect superoxide anions , 1998, FEBS letters.

[24]  A. Caldini,et al.  Synthesis of chemiluminogenic protein conjugates with dimethyl adipimidate for sensitive immunoassays. , 1986, Methods in enzymology.

[25]  A. Campbell,et al.  Two-site immunochemiluminometric assay for human alpha 1-fetoprotein. , 1983, Clinical chemistry.

[26]  W. Humphreys,et al.  A L.E.T. INDEPENDENT DOSIMETER BASED ON THE CHEMILUMINESCENT DETERMINATION OF H2O2 , 1965 .

[27]  L. Kricka,et al.  Chemiluminescent enzyme immunoassay of alpha-fetoprotein based on an adamantyl dioxetane phenyl phosphate substrate. , 1989, Clinical chemistry.

[28]  A. N. Díaz,et al.  Thin-layer chromatography with chemiluminescent detection of enhancers of the luminol-H2O2-peroxidase system , 1996 .

[29]  A. Schmitz,et al.  Monoclonal antibody based enzyme-linked and chemiluminescent assays for the human interleukin-1 receptor antagonist. Application to measure hIL-1ra levels in monocyte cultures and synovial fluids. , 1994, Journal of immunological methods.

[30]  M. Tabata,et al.  Determinations of lactate and lactate dehydrogenase activity in serum with the flow injection analysis system involving immobilized enzyme column and chemiluminescence. , 1991, Analytical biochemistry.

[31]  C. Kessler,et al.  Sensitive chemiluminescent detection of digoxigenin-labeled nucleic acids: a fast and simple protocol and its applications. , 1992, BioTechniques.

[32]  G. Schuster,et al.  Chemically initiated electron exchange luminescence. A new chemiluminescent reaction path for organic peroxides , 1977 .

[33]  G. Seitz,et al.  Intramolekulare Diels-Alder-Reaktionen mit 1,2,4-Triazinen und 1,2,4,5-Tetrazinen zu neuen Siebenring-anellierten Pyridinen und Pyridazinen , 1986 .

[34]  H E Hart,et al.  Scintillation proximity assay (SPA)--a new method of immunoassay. Direct and inhibition mode detection with human albumin and rabbit antihuman albumin. , 1979, Molecular immunology.

[35]  S. Girotti,et al.  Chemiluminescent assay for the detection of viral and plasmid DNA using digoxigenin-labeled probes. , 1991, Analytical biochemistry.

[36]  H. Neuvonen.  A two-intermediate model for imidazole-promoted peroxyoxalate chemiluminescence. , 1997, Journal of bioluminescence and chemiluminescence.

[37]  M. Fisher,et al.  An amplified chemiluminescent assay for the detection of alkaline phosphatase. , 1995, Analytical biochemistry.

[38]  W. P. Bennekom,et al.  Chemiluminescence and immunoassays. , 1994, Journal of pharmaceutical and biomedical analysis.

[39]  S. Girotti,et al.  Chemiluminescence dot blot hybridization assay for detection of B19 parvovirus DNA in human sera , 1991, Journal of clinical microbiology.

[40]  P. Luppa,et al.  6 alpha-biotinylated estrone: novel tracer in competitive chemiluminescence immunoassay of estrone in serum. , 1995, Clinical chemistry.

[41]  T. Goto,et al.  Chemiluminescence of a Cypridina Luciferin Analogue, 2-Methyl-6-phenyl-3,7-dihydroimidazo[1,2-a]pyrazin-3-one, in the Presence of the Xanthine–Xanthine Oxidase System , 1980 .

[42]  J. Arredondo,et al.  [Viral hepatitis (2)]. , 1987, Practica odontologica.

[43]  David J. Newman,et al.  Principles and Practice of Immunoassay , 1991, Palgrave Macmillan UK.

[44]  A. N. Díaz,et al.  Enhancement and inhibition of luminol chemiluminescence by phenolic acids , 1995 .

[45]  G. Houen,et al.  In situ detection of diamine oxidase activity using enhanced chemiluminescence. , 1996, Analytical biochemistry.

[46]  Carmen W. Huie,et al.  Peroxyoxalate chemiluminescence detection in capillary electrophoresis , 1993 .

[47]  R. Hart,et al.  The use of acridinium ester-labelled streptavidin in immunoassays. , 1987, Journal of immunological methods.

[48]  I. Bronstein,et al.  A comparison of chemiluminescent and colorimetric substrates in a hepatitis B virus DNA hybridization assay. , 1989, Analytical biochemistry.

[49]  Anthony K. Campbell,et al.  A homogeneous assay for biotin based on chemiluminescence energy transfer. , 1986, Analytical biochemistry.

[50]  U. Piran,et al.  New noncompetitive immunoassays of small analytes. , 1995, Clinical chemistry.

[51]  M. Saraste,et al.  FEBS Lett , 2000 .

[52]  M. Nakashima,et al.  A chemiluminescent detection of superoxide radical produced by adherent leucocytes to the subendothelium following thrombolysis: studies with a photochemically induced thrombosis model in the guinea pig femoral artery. , 1996, Atherosclerosis.

[53]  H. R. Schroeder,et al.  Chemiluminescence yields and detection limits of some isoluminol derivatives in various oxidation systems , 1978 .

[54]  J. Schlaeppi,et al.  Development of a Magnetic Particle-Based Automated Chemiluminescent Immunoassay for Triasulfuron , 1994 .

[55]  I. Tsukamoto,et al.  Peroxyoxalate chemiluminescent assay in aqueous solution with gamma-cyclodextrin. , 1992, Clinical chemistry.

[56]  O. Shimomura,et al.  Semi-synthetic aequorin. An improved tool for the measurement of calcium ion concentration. , 1988, The Biochemical journal.

[57]  F. G. Sánchez,et al.  Phenol derivatives as enhancers and inhibitors of luminol–H2O2–horseradish peroxidase chemiluminescence , 1998 .

[58]  L J Kricka,et al.  Chemiluminescent and bioluminescent techniques. , 1991, Clinical chemistry.

[59]  L. Kricka,et al.  Clinical and biochemical luminescence , 1982 .

[60]  P. Luppa,et al.  7 alpha-Biotinylated testosterone derivatives as tracers for a competitive chemiluminescence immunoassay of testosterone in serum. , 1997, Clinical chemistry.

[61]  P. S. Francis,et al.  Determination of α,4-dihydroxy-3-methoxybenzeneacetic acid (vanilmandelic acid) by flow injection analysis coupled with luminol–hexacyanoferrate(III) chemiluminescence detection , 1999 .

[62]  B. Åsman,et al.  Peripheral PMN cell activity in relation to treatment of juvenile periodontitis. , 1988, Scandinavian journal of dental research.

[63]  M. Nakano,et al.  A new and suitable reconstructed system for NADPH-dependent microsomal lipid peroxidation. , 1988, Biochemical and biophysical research communications.

[64]  O. Shimomura,et al.  Semi-synthetic aequorins with improved sensitivity to Ca2+ ions. , 1989, The Biochemical journal.

[65]  P. Ritch,et al.  Quantitation of interferon-induced Mx protein in whole blood lysates by an immunochemiluminescent assay: elimination of protease activity of cell lysates in toto. , 1994, Journal of immunological methods.

[66]  Miss A.O. Penney.  (b) , 1974, The New Yale Book of Quotations.

[67]  Y. Kato,et al.  A novel chemiluminescence from the reaction of 9-arylmethylene-10-methyl-9,10-dihydroacridines and peroxyacid , 1994 .

[68]  H. Nakazawa,et al.  Chemiluminescence of β-lactam antibiotics based on the luminol reaction , 1999 .

[69]  K. Imai,et al.  Sensitive flow-injection method with peroxyoxalate chemiluminescence detection combined with preparative high-performance liquid chromatography for determination of choline-containing phospholipids in human serum. , 1996, Journal of chromatography. B, Biomedical applications.

[70]  Ian Magrath,et al.  A chemiluminescent assay for quantitation of β-galactosidase in the femtogram range: Application to quantitation of β-galactosidase in lacZ-transfected cells , 1991 .

[71]  C. Matsubara,et al.  [Flow injection analysis for determination of choline-containing phospholipids by luminol chemiluminescence]. , 1992, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[72]  M. Nakamura,et al.  One- and two-electron oxidations of luminol by peroxidase systems. , 1998, Free radical biology & medicine.

[73]  K. Li,et al.  Study of the Catalytic Effect of Copper(II)–Protein Complexes on Luminol-H2O2 Chemiluminescence Reaction and its Analytical Application , 1999 .

[74]  C. Dahlgren,et al.  Isoluminol-enhanced chemiluminescence: a sensitive method to study the release of superoxide anion from human neutrophils. , 1996, Free radical biology & medicine.

[75]  L J Kricka,et al.  Phenols as enhancers of the chemiluminescent horseradish peroxidase-luminol-hydrogen peroxide reaction: application in luminescence-monitored enzyme immunoassays. , 1985, Clinical chemistry.

[76]  J. Lovillo,et al.  Enhancer effect of fluorescein on the luminol-H2O2-horseradish peroxidase chemiluminescence: energy transfer process. , 1997, Journal of bioluminescence and chemiluminescence.

[77]  R. S. Handley,et al.  Chemical and enzymatic triggering of 1,2-dioxetanes. 1: Aryl esterase-catalyzed chemiluminescence from a naphthyl acetate-substituted dioxetane , 1987 .

[78]  R. de Hertogh,et al.  Rapid, automated quantification of total human chorionic gonadotropin in serum by a chemiluminescent enzyme immunometric assay. , 1995, Clinical chemistry.

[79]  L. Kricka,et al.  4-Phenylylboronic acid: a new type of enhancer for the horseradish peroxidase catalysed chemiluminescent oxidation of luminol. , 1995, Journal of bioluminescence and chemiluminescence.

[80]  J. Fernández-Romero,et al.  Flow-through optical biosensor based on the permanent immobilization of an enzyme and transient retention of a reaction product. , 1993, Analytical chemistry.

[81]  L J Kricka,et al.  Enhanced chemiluminescent reactions catalyzed by horseradish peroxidase. , 1986, Methods in enzymology.

[82]  J. W. Leidy.  High sensitivity two-site immunoradiometric and immunochemiluminometric assays for rat growth hormone-releasing hormone. Development of an acridinium ester based chemiluminescence assay for the avidin-coated bead system. , 1994, Journal of immunological methods.

[83]  S. R. Crouch,et al.  Factors Affecting Zone Variance in a Capillary Flow Injection System , 1997 .

[84]  K. Utsumi,et al.  Luminol chemiluminescence and active oxygen generation by activated neutrophils. , 1991, Archives of biochemistry and biophysics.

[85]  F. J. Alba,et al.  Nonenzymatic chemiluminescent detection and quantitation of total protein on Western and slot blots allowing subsequent immunodetection and sequencing , 1997, Electrophoresis.

[86]  A. Townshend.  Solution chemiluminescence—some recent analytical developments. Plenary lecture , 1990 .

[87]  Makoto Haga,et al.  A Liposome Immunoassay Based on a Chemiluminescense Reaction , 1989 .

[88]  G. Martiny-Baron,et al.  Chemiluminescence immunoassay for vascular endothelial growth factor (vascular permeability factor) in tumor-tissue homogenates. , 1996, Clinical chemistry.

[89]  I. Bronstein,et al.  Improved chemiluminescent DNA sequencing. , 1991, BioTechniques.

[90]  P. Trayhurn,et al.  Rapid chemiluminescent detection of mRNAs on Northern blots with digoxigenin end‐labelled oligonucleotides , 1995, Electrophoresis.

[91]  F. Lu,et al.  A simple chemiluminescence assay for detecting oxidative stress in ischemic limb injury. , 1996, Free radical biology & medicine.

[92]  A. Gasbarrini,et al.  Chemiluminescent real time imaging of post-ischemic oxygen free radicals formation in livers isolated from young and old rats. , 1998, Free radical biology & medicine.

[93]  H. Homma,et al.  Sensitive detection of near-infrared fluorescent dyes using high-performance liquid chromatography with peroxyoxalate chemiluminescence detection system. , 1996, Biomedical chromatography : BMC.

[94]  R. Knuppen,et al.  Chemiluminescent labels for steroid immunoassays. , 1987, Journal of steroid biochemistry.

[95]  O. Shimomura,et al.  Coelenterazine analogs as chemiluminescent probe for superoxide anion. , 1997, Analytical biochemistry.

[96]  T. Dörk,et al.  Analysis of microsatellites by direct blotting electrophoresis and chemiluminescence detection , 1995, Electrophoresis.

[97]  R. Radi,et al.  Comparison of the effects of superoxide dismutase and cytochrome c on luminol chemiluminescence produced by xanthine oxidase-catalyzed reactions. , 1989, Biochimica et biophysica acta.

[98]  N. C. Nelson,et al.  Simultaneous detection of multiple nucleic acid targets in a homogeneous format. , 1996, Biochemistry.

[99]  S. Kamihira,et al.  Chemiluminescence Immunoassay to Detect Anti‐HTLV‐I Antibodies , 1993, Japanese journal of cancer research : Gann.

[100]  K. Kopecky,et al.  Luminescence in the thermal decomposition of 3,3,4-trimethyl-1,2-dioxetane , 1969 .

[101]  P. Wernet,et al.  Benzodiazepines and their solvents influence neutrophil granulocyte function. , 1993, British journal of anaesthesia.

[102]  C. Dahlgren,et al.  Analysis of horseradish peroxidase-amplified chemiluminescence produced by human neutrophils reveals a role for the superoxide anion in the light emitting reaction. , 1988, Analytical biochemistry.

[103]  K. Fujimoto,et al.  Chemiluminescent simultaneous determination of phosphatidylcholine hydroperoxide and phosphatidylethanolamine hydroperoxide in the liver and brain of the rat. , 1992, Journal of lipid research.

[104]  H. Yamada,et al.  Luminol chemiluminescence reaction catalyzed by a microbial peroxidase. , 1990, Analytical Biochemistry.

[105]  Kazufumi Shimizu,et al.  A novel chemiluminescence from the reaction of 9-arylmethylene-10-methyl-9,10-dihydroacridines and dimethyldioxirane , 1994 .

[106]  R. Taylor,et al.  Proinsulin level in diabetes mellitus measured by a new immunochemiluminometric assay. , 1995, Annals of clinical and laboratory science.

[107]  K. Kondo,et al.  Establishment of the optically pumped chemiluminescence technique for diagnostics , 1993 .

[108]  A homogeneous immunoassay for cyclic nucleotides based on chemiluminescence energy transfer. , 1983, The Biochemical journal.

[109]  P E Stanley,et al.  Chemiluminescent and bioluminescent reporter gene assays. , 1994, Analytical biochemistry.

[110]  Knox Van Dyke,et al.  Bioluminescence and chemiluminescence : instruments and applications , 1985 .

[111]  L. Kricka,et al.  Improved chemiluminescent western blotting procedure. , 1992, BioTechniques.

[112]  K. Nakao,et al.  Direct determination of plasma endothelin-I by chemiluminescence enzyme immunoassay. , 1996, Clinical chemistry.

[113]  Y. Ashihara,et al.  Rapid and sensitive chemiluminescent enzyme immunoassay for measuring tumor markers. , 1991, Clinical chemistry.

[114]  S. Berson,et al.  Assay of Plasma Insulin in Human Subjects by Immunological Methods , 1959, Nature.

[115]  V. V. Rogovine,et al.  The increasing effect of some synthetic peptides on luminol‐dependent chemiluminescence of mouse blood , 1995, Cell biochemistry and function.

[116]  T. Hasebe,et al.  Simultaneous Flow Injection Determination of Acetylcholine and Choline Based on Luminol Chemiluminescence in a Micellar System with On-Line Dialysis , 1997 .

[117]  M. Serteser,et al.  The effects of detergents on t-butyl hydroperoxide-induced chemiluminescence , 1996, International journal of clinical & laboratory research.

[118]  F. McCapra.  The chemiluminescence of organic compounds , 1970 .

[119]  K. Asano,et al.  Role of hydrogen peroxide for cell death induction by sodium 5,6-benzylidene-L-ascorbate. , 1998, Anticancer research.

[120]  L. Kricka,et al.  Influence of different luminols on the characteristics of the chemiluminescence reaction in human neutrophils. , 1995, Journal of bioluminescence and chemiluminescence.

[121]  V. Fert,et al.  Application of a long-term enhanced xanthine oxidase-induced luminescence in solid-phase immunoassays. , 1990, Analytical biochemistry.

[122]  S. Yoshikawa,et al.  Homogeneous chemiluminescent immunoassay based on complement-mediated hemolysis of red blood cells. , 1990, Analytical chemistry.

[123]  H. Repo,et al.  Determination of oxygen radical production in spondyloarthropathies by whole blood chemiluminescence. , 1991, Annals of the rheumatic diseases.

[124]  S. Greenfield,et al.  Autoxidation of dopamine: a comparison of luminescent and spectrophotometric detection in basic solutions. , 1995, Free radical biology & medicine.

[125]  R. Radi,et al.  Luminol chemiluminescence using xanthine and hypoxanthine as xanthine oxidase substrates. , 1990, Free radical biology & medicine.

[126]  A. Eisenberg,et al.  Chemiluminescent detection of DNA probes in forensic analysis , 1995, Electrophoresis.

[127]  D. Kacian,et al.  Chemiluminescent DNA probes: a comparison of the acridinium ester and dioxetane detection systems and their use in clinical diagnostic assays. , 1990, Clinica chimica acta; international journal of clinical chemistry.

[128]  W. Qin,et al.  Chemiluminescence flow system for vanadium(v) with immobilized reagents. , 1997, The Analyst.

[129]  A. Tsuji,et al.  Chemiluminescent assay of various enzymes using indoxyl derivatives as substrate and its applications to enzyme immunoassay and DNA probe assay. , 1991, Analytical biochemistry.

[130]  T. Kamidate,et al.  Enhanced chemiluminescence of lucigenin with epinephrine in cationic surfactant micelles containing periodate. , 1995, Journal of bioluminescence and chemiluminescence.

[131]  Toshiki Tani,et al.  Resolution of Amino Thiols in Time-Resolved Luminol Chemiluminescence Catalyzed by Peroxidases , 1998 .

[132]  P E Stanley,et al.  Bioluminescence and chemiluminescence literature. 263 references concerning nitric oxide and chemiluminescence, with some from the chemical literature but mainly from the life science literature (1964-early 1996). , 1996, Journal of bioluminescence and chemiluminescence.

[133]  J H Luong,et al.  Monitoring glutamine in animal cell cultures using a chemiluminescence fiber optic biosensor , 1993, Biotechnology and bioengineering.

[134]  Loïc J. Blum.  Chemiluminescent flow injection analysis of glucose in drinks with a bienzyme fiberoptic biosensor , 1993 .

[135]  K. Zaitsu,et al.  1,2-Diarylethylenediamines as sensitive pre-column derivatizing reagents for chemiluminescence detection of catecholamines in HPLC. , 1995, Journal of pharmaceutical and biomedical analysis.

[136]  E. H. White,et al.  [36] The chemiluminescence of luminol and related hydrazides , 1978 .

[137]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[138]  E. Deeb,et al.  A rapid and simple chemiluminescent assay for Escherichia coli beta-galactosidase. , 1992, BioTechniques.

[139]  R. S. Handley,et al.  Chemical and enzymatic triggering of 1,2-dioxetanes. 3: alkaline phosphatase-catalyzed chemiluminescence from an aryl phosphate-substituted dioxetane , 1987 .

[140]  Alan A. Wilson,et al.  Chemiluminescence involving acidic and ambident ion light emitters: the chemiluminescence of the 9-acridinepercarboxylate anion , 1987 .

[141]  M. Nakano,et al.  Continuous detection of superoxide in situ during ischemia and reperfusion in the rabbit heart. , 1997, Japanese heart journal.

[142]  A. Campbell,et al.  Acridinium esters as high-specific-activity labels in immunoassay. , 1983, Clinical chemistry.

[143]  W. Neupert,et al.  A new reliable chemiluminescence immunoassay (CLIA) for prostaglandin E2 using enhanced luminol as substrate. , 1996, Prostaglandins.

[144]  K. Gleu,et al.  Die Chemiluminescenz der Dimethyl‐diacridyliumsalze , 1935 .

[145]  J. Mcghee,et al.  Luminometry: a novel bioluminescent immunoassay enhances the quantitation of mucosal and systemic antibody responses. , 1996, Journal of immunological methods.

[146]  J. Kulys,et al.  Chemiluminescent immunoassay (CLIA) for the detection of brucellosis and tularaemia antigens. , 1995, Journal of bioluminescence and chemiluminescence.

[147]  Dolores Pérez-Bendito,et al.  Improved Peroxyoxalate Chemiluminescence-Based Determinations by Use of Continuous Reagent Addition To Remove Background Emission , 1994 .

[148]  M. Haga,et al.  An improved chemiluminescence-based liposome immunoassay involving apoenzyme. , 1990, Chemical & pharmaceutical bulletin.

[149]  S. Schulman,et al.  Penicillin-enhanced chemiluminescence of the luminol-H2O2-Co2+ system. , 1991, Journal of pharmaceutical sciences.

[150]  John B. Shoven,et al.  I , Edinburgh Medical and Surgical Journal.

[151]  A. Roda,et al.  A chemiluminescent flow sensing device for determination of choline and phospholipase D activity in biological samples. , 1997, Analytical biochemistry.

[152]  V. Zachar,et al.  Enhanced chemiluminescence-based hybridization analysis for PCR-mediated HIV-1 DNA detection offers an alternative to 32P-labelled probes. , 1991, Journal of virological methods.

[153]  Y. Ohkura,et al.  Chemiluminescence determination of catecholamines in human blood plasma and urine using 1,2-diphenylethylenediamine as pre-column derivatization reagent in liquid chromatography , 1994 .

[154]  D. M. Heffelfinger,et al.  Imaging and quantitation of chemiluminescence using photoexcitable storage phosphor screen. , 1995, Analytical Biochemistry.

[155]  L. Stryer.  Fluorescence energy transfer as a spectroscopic ruler. , 1978, Annual review of biochemistry.

[156]  M. Bednar,et al.  Ticlopidine augments luminol-dependent chemiluminescence in human neutrophils. , 1995, Journal of bioluminescence and chemiluminescence.

[157]  L. Kricka,et al.  Super-sensitive enzyme immunoassay for thyroid stimulating hormone using a new synergistic enhanced chemiluminescent endpoint. , 1996, Journal of bioluminescence and chemiluminescence (Print).

[158]  N. Christofides,et al.  Enhanced chemiluminescence labeled-antibody immunoassay (Amerlite-MAB) for free thyroxine: design, development, and technical validation. , 1995, Clinical chemistry.