Data-Driven Feedforward Control for Electroporation Mediated Gene Delivery in Gene Therapy

This brief proposes a novel data-driven feedforward control mechanism to regulate micro/nanoscale systems subject to insufficient measurements. The theoretical framework integrates data-driven planning and formulates a feedforward controller, which is successfully applied to an electroporation mediated gene delivery problem in gene therapy. Nonlinear dynamics modeling and analysis of the biological cell electroporation process, especially hysteresis and nonlinear jump phenomenon, are discussed. Simulation results demonstrate that the proposed control outperforms existing methods in the open literature.

[1]  L. Chernomordik,et al.  Breakdown of lipid bilayer membranes in an electric field , 1983 .

[2]  B. Paden,et al.  Exact output tracking for nonlinear time-varying systems , 1994, Proceedings of 1994 33rd IEEE Conference on Decision and Control.

[3]  Tzyh Jong Tarn,et al.  Stability analysis of non-time referenced Internet-based telerobotic systems , 2000, Robotics Auton. Syst..

[4]  D. Wells,et al.  Electroporation for gene transfer to skeletal muscles: current status. , 2004, BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy.

[5]  J. Grizzle,et al.  Necessary conditions for asymptotic tracking in nonlinear systems , 1994, IEEE Trans. Autom. Control..

[6]  M. Brokate,et al.  Hysteresis and Phase Transitions , 1996 .

[7]  S. Weidmann.  Electrical constants of trabecular muscle from mammalian heart , 1970, The Journal of physiology.

[8]  Tzyh Jong Tarn,et al.  Intelligent planning and control for multirobot coordination: An event-based approach , 1996, IEEE Trans. Robotics Autom..

[9]  Wanda Krassowska,et al.  Asymptotic model of electroporation , 1999 .

[10]  J. Gehl,et al.  Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research. , 2003, Acta physiologica Scandinavica.

[11]  D. Wells,et al.  Gene Therapy Progress and Prospects: Electroporation and other physical methods , 2004, Gene Therapy.

[12]  W. Krassowska,et al.  Modeling electroporation in a single cell. I. Effects Of field strength and rest potential. , 1999, Biophysical journal.

[13]  Wanda Krassowska,et al.  Model of creation and evolution of stable electropores for DNA delivery. , 2004, Biophysical journal.

[14]  van Nieuwstadt,et al.  Trajectory generation for nonlinear control systems , 1996 .

[15]  Mingjun Zhang,et al.  Control of pore radius regulation for electroporation-based drug delivery , 2010 .

[16]  Gang Tao,et al.  Adaptive control of plants with unknown hystereses , 1995 .

[17]  Daniel Scherman,et al.  In vivo plasmid DNA electrotransfer. , 2002, Current opinion in biotechnology.

[18]  W. Krassowska,et al.  Modeling electroporation in a single cell. , 2007, Biophysical journal.

[19]  Jill McMahon,et al.  Electroporation for Gene Transfer to Skeletal Muscles , 2012, BioDrugs.

[20]  J. Israelachvili.  Intermolecular and surface forces , 1985 .

[21]  Ruoting Yang.  Data-driven two degree-of-freedom control for robust intelligent life science automation , 2008 .

[22]  S. Rosenberg,et al.  T Lymphocyte-Directed Gene Therapy for ADA− SCID: Initial Trial Results After 4 Years , 1995, Science.

[23]  J Teissié,et al.  Electropermeabilization of mammalian cells to macromolecules: control by pulse duration. , 1998, Biophysical journal.

[24]  Aurelio Piazzi,et al.  Optimal inversion-based control for the set-point regulation of nonminimum-phase uncertain scalar systems , 2001, IEEE Trans. Autom. Control..

[25]  E Neumann,et al.  Calcium-mediated DNA adsorption to yeast cells and kinetics of cell transformation by electroporation. , 1996, Biophysical journal.

[26]  Bayu Jayawardhana,et al.  PID control of second-order systems with hysteresis , 2007, 2007 46th IEEE Conference on Decision and Control.

[27]  L. Chernomordik,et al.  Reversible electrical breakdown of lipid bilayers: formation and evolution of pores. , 1988, Biochimica et biophysica acta.

[28]  J. Weaver,et al.  Theory of electroporation of planar bilayer membranes: predictions of the aqueous area, change in capacitance, and pore-pore separation. , 1994, Biophysical journal.

[29]  Suhada Jayasuriya,et al.  Feedforward controllers and tracking accuracy in the presence of plant uncertainties , 1994, Proceedings of 1994 American Control Conference - ACC '94.

[30]  Mingjun Zhang,et al.  Modeling and Control of Electroporation-Mediated Gene Delivery , 2008, 2008 8th IEEE Conference on Nanotechnology.

[31]  W. Krassowska,et al.  Modeling postshock evolution of large electropores. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[32]  A. Isidori.  Nonlinear Control Systems , 1985 .