Higher doses of tisagenlecleucel are associated with improved outcomes: a report from the pediatric real-world CAR consortium

Key Points • Currently, patients receive a single dose of tisagenlecleucel across a wide dose range.• Clinicians could choose to give a higher dose of tisagenlecleucel upfront, within the approved dose range, to optimize response.

[1]  N. Kröger,et al.  Axicabtagene ciloleucel in vivo expansion and treatment outcome in aggressive B-cell lymphoma in a real-world setting. , 2021, Blood advances.

[2]  A. Logan,et al.  KTE-X19 anti-CD19 CAR T-cell therapy in adult relapsed/refractory acute lymphoblastic leukemia: ZUMA-3 phase 1 results. , 2021, Blood.

[3]  Matthew J. Frigault,et al.  Real-world evidence of tisagenlecleucel for pediatric acute lymphoblastic leukemia and non-Hodgkin lymphoma. , 2020, Blood advances.

[4]  S. Grupp,et al.  Clinical Pharmacology of Tisagenlecleucel in B-cell Acute Lymphoblastic Leukemia , 2018, Clinical Cancer Research.

[5]  S. Rives,et al.  Considerations for tisagenlecleucel dosing rationale. , 2018 .

[6]  K. Davis,et al.  Tisagenlecleucel in Children and Young Adults with B‐Cell Lymphoblastic Leukemia , 2018, The New England journal of medicine.

[7]  Pamela A Shaw,et al.  Chimeric antigen receptor T cells for sustained remissions in leukemia. , 2014, The New England journal of medicine.

[8]  S. Rosenberg,et al.  Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells. , 2010, Blood.

[9]  W. Wilson,et al.  Construction and Preclinical Evaluation of an Anti-CD19 Chimeric Antigen Receptor , 2009, Journal of immunotherapy.

[10]  D. Campana,et al.  Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

[11]  K. Hornik,et al.  A Lego System for Conditional Inference , 2006 .

[12]  F. Yates The analysis of contingency tables with groupings based on quantitative characters. , 1948, Biometrika.

[13]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .