Synthesis of a membrane-insertable, sodium cation conducting channel : kinetic analysis by dynamic 23Na NMR

We report herein the synthesis and characterziation of a rationally designed, completely synthetic compound that inserts in phosphatidylcholine (pc) vesicles. Using the dynamic (equilibrium) NMR methode presented initially by Riddell and Hayer, recently extended by Hinton et al., we demonstrate that this molecule significantly enhances the rate at which Na + is transported compared to a closely related carrier model