Speckle-based x-ray dark-field tomography of an attenuating object

Spatial resolution in standard phase-contrast X-ray imaging is limited by the finite number and size of detector pixels. As a result, this limits the size of features that can be seen directly in projection images or tomographic reconstructions. Dark-field imaging allows information regarding such features to be obtained, as the reconstructed image is a measure of the position-dependent small-angle X-ray scattering of incident rays from the unresolved microstructure. In this paper we utilize an intrinsic speckle-tracking-based X-ray imaging technique to obtain the effective dark-field signal from a wood sample. This effective dark-field signal is extracted using a Fokker-Planck type formalism, which models the deformations of illuminating reference-beam speckles due to both coherent and diffusive scatter from the sample. We here assume that (a) small-angle scattering fans at the exit surface of the sample are rotationally symmetric, and (b) the object has both attenuating and refractive properties. The associated inverse problem, of extracting the effective dark-field signal, is numerically stabilised using a “weighted determinants” approach. Effective dark-field projection images are presented, as well as the dark-field tomographic reconstructions obtained using Fokker-Planck implicit speckle-tracking.

[1]  A. Fehringer,et al.  Grating-based X-ray Dark-field Computed Tomography of Living Mice , 2015, EBioMedicine.

[2]  F. Boas,et al.  CT artifacts: Causes and reduction techniques , 2012 .

[3]  David M Paganin,et al.  Applying the Fokker–Planck equation to grating-based x-ray phase and dark-field imaging , 2019, Scientific Reports.

[4]  W. Ehrenberg,et al.  Small-Angle X-Ray Scattering , 1952, Nature.

[5]  F Arfelli,et al.  An innovative digital imaging set-up allowing a low-dose approach to phase contrast applications in the medical field. , 2001, Medical physics.

[6]  Timm Weitkamp,et al.  X-ray wavefront analysis and optics characterization with a grating interferometer , 2005 .

[7]  Paolo Russo,et al.  Handbook of X-ray Imaging : Physics and Technology , 2017 .

[8]  Franz Pfeiffer,et al.  X-ray dark-field imaging of the human lung—A feasibility study on a deceased body , 2018, PloS one.

[9]  David M Paganin,et al.  X-ray Fokker–Planck equation for paraxial imaging , 2019, Scientific Reports.

[10]  Boosting phase contrast with a grating Bonse–Hart interferometer of 200 nanometre grating period , 2014, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[11]  Kentaro Uesugi,et al.  X-ray phase, absorption and scatter retrieval using two or more phase contrast images. , 2010, Optics express.

[12]  U. Bonse,et al.  AN X‐RAY INTERFEROMETER , 1965 .

[13]  Detection of individual sub-pixel features in edge-illumination x-ray phase contrast imaging by means of the dark-field channel , 2020 .

[14]  Paola Coan,et al.  A method to extract quantitative information in analyzer-based x-ray phase contrast imaging , 2003 .

[15]  William H. Press,et al.  Numerical Recipes in FORTRAN - The Art of Scientific Computing, 2nd Edition , 1987 .

[16]  D. Paganin,et al.  Directional dark-field implicit x-ray speckle tracking using an anisotropic-diffusion Fokker-Planck equation , 2021, Physical Review A.

[17]  Franz Pfeiffer,et al.  X-ray dark-field and phase-contrast imaging using a grating interferometer , 2009 .

[18]  Jun Zhao,et al.  Fast grating-based X-ray phase-contrast tomosynthesis , 2013, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[19]  S. Wilkins,et al.  Phase-contrast imaging of weakly absorbing materials using hard X-rays , 1995, Nature.

[20]  F. Pfeiffer,et al.  Speckle-based x-ray phase-contrast and dark-field imaging with a laboratory source. , 2014, Physical review letters.

[21]  Han Wen,et al.  A grating-based single-shot x-ray phase contrast and diffraction method for in vivo imaging. , 2010, Medical physics.

[22]  K. Nugent,et al.  Quantitative Phase Imaging Using Hard X Rays. , 1996, Physical review letters.

[23]  P. C. Brennan,et al.  Dark-field signal extraction in propagation-based phase-contrast imaging. , 2020, Physics in medicine and biology.

[24]  Eric Ziegler,et al.  Two-dimensional x-ray beam phase sensing. , 2012, Physical review letters.

[25]  Kentaro Uesugi,et al.  Phase contrast image segmentation using a Laue analyser crystal , 2011, Physics in medicine and biology.

[26]  O. Bunk,et al.  Hard-X-ray dark-field imaging using a grating interferometer. , 2008, Nature materials.

[27]  Kentaro Uesugi,et al.  Simultaneous acquisition of dual analyser-based phase contrast X-ray images for small animal imaging. , 2008, European journal of radiology.

[28]  M. Glas,et al.  Principles of Computerized Tomographic Imaging , 2000 .

[29]  Jovan G. Brankov,et al.  Sampling strategies in multiple-image radiography , 2008, 2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro.

[30]  Atsushi Momose,et al.  Demonstration of phase-contrast X-ray computed tomography using an X-ray interferometer , 1995 .

[31]  P. Cloetens,et al.  Phase objects in synchrotron radiation hard x-ray imaging , 1996 .

[32]  A. Snigirev,et al.  On the possibilities of x-ray phase contrast microimaging by coherent high-energy synchrotron radiation , 1995 .

[33]  Atsushi Momose,et al.  X-Ray Phase Imaging with Single Phase Grating , 2007 .

[34]  D. Paganin,et al.  X-ray multi-modal intrinsic-speckle-tracking , 2019, Journal of Optics.

[35]  Metin Tolan,et al.  Über eine neue Art von Strahlen , 2010 .

[36]  M. Teague Deterministic phase retrieval: a Green’s function solution , 1983 .

[37]  P. Fromme,et al.  Edge-illumination X-ray dark-field imaging for visualising defects in composite structures , 2015 .

[38]  Timur E. Gureyev,et al.  Toolbox for advanced x-ray image processing , 2011, Optical Engineering + Applications.

[39]  David M. Paganin,et al.  Coherent X-Ray Optics , 2006 .

[40]  Almerico Murli,et al.  The Wiener filter and regularization methods for image restoration problems , 1999, Proceedings 10th International Conference on Image Analysis and Processing.

[41]  C. David,et al.  Differential x-ray phase contrast imaging using a shearing interferometer , 2002 .

[42]  Tetsuya Yuasa,et al.  Dark-Field Imaging: Recent developments and potential clinical applications. , 2016, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[43]  D. Paganin,et al.  Single-Shot X-Ray Speckle-Based Imaging of a Single-Material Object , 2019, 1908.00411.

[44]  Arndt Last,et al.  X-ray Phase-Contrast Imaging and Metrology through Unified Modulated Pattern Analysis. , 2017, Physical review letters.

[45]  Dinghua Zhang,et al.  Post-processing method for the removal of mixed ring artifacts in CT images. , 2020, Optics express.

[46]  Franz Pfeiffer,et al.  Grating-based X-ray dark-field imaging: a new paradigm in radiography , 2014, Current Radiology Reports.

[47]  S. Wilkins,et al.  Simultaneous phase and amplitude extraction from a single defocused image of a homogeneous object , 2002, Journal of microscopy.

[48]  Atsushi Momose,et al.  Demonstration of X-Ray Talbot Interferometry , 2003 .

[49]  P. Sabatier,et al.  Past and future of inverse problems , 2000 .

[50]  Claude Brezinski,et al.  Numerical recipes in Fortran (The art of scientific computing) : W.H. Press, S.A. Teukolsky, W.T. Vetterling and B.P. Flannery, Cambridge Univ. Press, Cambridge, 2nd ed., 1992. 963 pp., US$49.95, ISBN 0-521-43064-X.☆ , 1993 .

[51]  S. Wilkins,et al.  Phase-contrast imaging using polychromatic hard X-rays , 1996, Nature.

[52]  K. Mori,et al.  Improving contrast and spatial resolution in crystal analyzer-based X-ray dark-field imaging: Theoretical considerations and experimental demonstration. , 2020, Medical physics.

[53]  M. E. Alferieff,et al.  Refraction contrast in X-ray introscopy , 1991 .

[54]  Marie-Christine Zdora,et al.  State of the Art of X-ray Speckle-Based Phase-Contrast and Dark-Field Imaging , 2018, J. Imaging.

[55]  Eric Ziegler,et al.  X-ray Multimodal Tomography Using Speckle-Vector Tracking , 2015, 1507.05807.

[56]  David M Paganin,et al.  Quantitative single-exposure x-ray phase contrast imaging using a single attenuation grid. , 2011, Optics express.

[57]  Atsushi Momose,et al.  Phase Tomography by X-ray Talbot Interferometry for Biological Imaging , 2006 .

[58]  R. Speller,et al.  A coded-aperture technique allowing x-ray phase contrast imaging with conventional sources , 2007 .

[59]  V. N. Ingal,et al.  X-ray plane-wave topography observation of the phase contrast from a non-crystalline object , 1995 .

[60]  Franz Pfeiffer,et al.  X-ray phase imaging with a grating interferometer. , 2005, Optics express.

[61]  N. Galatsanos,et al.  Multiple-image radiography. , 2003, Physics in medicine and biology.

[62]  O. Bunk,et al.  Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources , 2006 .

[63]  D. Paganin,et al.  Single-image geometric-flow x-ray speckle tracking , 2018, Physical Review A.