Profiling and classification of illicit heroin by ICP-MS analysis of inorganic elements.

Nineteen inorganic elements (Ag, As, Ba, Cd, Co, Cr, Cu, Mn, Mo, Ni, P, Pb, Se, Sb, Th, Tl, U, V and Zn) in heroin samples were determined using inductive coupled plasma mass spectrometry (ICP-MS). After Wilcoxon-Mann-Whitney test and correlation analysis, 10 element contents (P, V, Cr, Ni, Cu, Zn, As, Se, Pb, U) and 7 element ratios (U/Ba, Ba/Pb, Cd/Mn, Co/Ni, V/Cr, P/V, Cd/V) were found to be evidently different between heroin samples from "Golden Crescent" and "Golden Triangle". Based on the data set of these 17 variables in 150 authentic heroin samples, classification of origins was successfully achieved utilizing principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA). By comparison experiment on 907 unknown samples, the developed discriminant model was proven to be consistent with the widely used organic profiling method, and meanwhile the time consumed per sample was markedly saved, which facilitates high throughput screening in routine analysis.

[1]  Jianren Gu,et al.  Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis. , 2005, Analytical chemistry.

[2]  P. Bermejo-Barrera,et al.  Determination of traces of chromium in cocaine and heroin by flameless atomic absorption spectrometry. , 1996, Talanta.

[3]  Peter J Mumby,et al.  Statistical power of non-parametric tests: a quick guide for designing sampling strategies. , 2002, Marine pollution bulletin.

[4]  H. Tsuchihashi,et al.  Analyses of impurities in methamphetamine by inductively coupled plasma mass spectrometry and ion chromatography. , 1988, Journal of chromatography.

[5]  A Bolck,et al.  Elemental analysis of 3,4-methylenedioxymethamphetamine (MDMA): A tool to determine the synthesis method and trace links. , 2007, Forensic science international.

[6]  C. Junot,et al.  Metabolomic investigation of the response of the model plant Arabidopsis thaliana to cadmium exposure: Evaluation of data pretreatment methods for further statistical analyses , 2008 .

[7]  E. Domínguez,et al.  Metal contamination in illicit samples of heroin. , 1999, Journal of forensic sciences.

[8]  P. Bermejo-Barrera,et al.  Direct determination of nickel in heroin and cocaine by electrothermal atomic absorption spectrometry using deuterium arc background correction combined with chemical modification , 1995 .

[9]  Sueshige Seta,et al.  Analysis of inorganic impurities in seized methamphetamine samples , 1994 .

[10]  M. Cole,et al.  Headspace analysis of solvents in cocaine and heroin samples. , 1997, Science & justice : journal of the Forensic Science Society.

[11]  G. Tan,et al.  ICP-MS Method Validation for the Analysis of Trace Elements in Illicit Heroin , 2012 .

[12]  T. Bora,et al.  Levels of trace and major elements in illicit heroin. , 2002, Journal of forensic sciences.

[13]  I. Lurie,et al.  Use of dynamically coated capillaries for the determination of heroin, basic impurities and adulterants with capillary electrophoresis. , 2004, Journal of chromatography. A.

[14]  R. Watling.  Sourcing the provenance of cannabis crops using inter-element association patterns ‘fingerprinting’ and laser ablation inductively coupled plasma mass spectrometry , 1998 .

[15]  R. J. Wells,et al.  Preliminary investigation of heroin fingerprinting using trace element concentrations , 1998 .

[16]  S. Caroli,et al.  Characterization of cocaine and heroin samples as a function of their trace element content: An analytical pilot study , 1992 .

[17]  David R Morello,et al.  Signature Profiling and Classification of Illicit Heroin by GC‐MS Analysis of Acidic and Neutral Manufacturing Impurities , 2010, Journal of forensic sciences.

[18]  Stéphane COMMENT,et al.  THE ANALYSIS OF ECSTASY TABLETS BY ICP / MS AND ICP / AES , 2008 .

[19]  Morten W Fagerland,et al.  t-tests, non-parametric tests, and large studies—a paradox of statistical practice? , 2012, BMC Medical Research Methodology.

[20]  James Robertson,et al.  Chemical Profiling of Heroin Recovered from the North Korean Merchant Vessel Pong Su , 2006, Journal of forensic sciences.

[21]  David Littlejohn,et al.  Classification of ecstasy tablets using trace metal analysis with the application of chemometric procedures and artificial neural network algorithms. , 2004, The Analyst.

[22]  Jessica DeVries.  About t-tests , 2007 .