Assessment of cardiac performance with quantitative radionuclide angiocardiography. Effects of oral propranolol on global and regional left ventricular function in coronary artery disease.

The effect of incremental dosages of oral propranolol (mean peak dose of 165 +/- 13 mg/day) of left ventricular ejection fraction, ejection rate and regional wall motion was studied sequentially in 22 stable, resting patients with coronary artery disease using a geometry-independent first-pass radionuclide angiocardiographic technique. All patients improved clinically, in association with a fall in heart rate and therapeutic serum propranolol levels. No significant changes were noted in ejection fraction, ejection rate or regional wall motion. No patient developed a new regional wall motion disturbance. Thus, oral propranolol administered at clinically effective antianginal dosages in patients with stable coronary artery disease does not appear to have significant deleterious effects on resting left ventricular performance.

[1]  B. Zaret,et al.  Variability in sequential measures of left ventricular performance assessed with radionuclide angiocardiography. , 1978, The American journal of cardiology.

[2]  R. Marshall,et al.  Assessment of Cardiac Performance with Quantitative Radionuclide Angiocardiography: Sequential Left Ventricular Ejection Fraction, Normalized Left Ventricular Ejection Rate, and Regional Wall Motion , 1977, Circulation.

[3]  M. Pagani,et al.  Effects of propranolol on regional myocardial function, electrograms, and blood flow in conscious dogs with myocardial ischemia. , 1977, The Journal of clinical investigation.

[4]  H. Gold,et al.  Propranolol-induced reduction of signs of ischemic injury during acute myocardial infarction. , 1976, The American journal of cardiology.

[5]  R. Shanks,et al.  The Clinical Pharmacology of Beta Adrenergic Blocking Drugs , 1976, Journal of the Royal College of Physicians of London.

[6]  S. Treves,et al.  Quantitative radionuclide angiocardiography. Determination of left ventricular ejection fraction in children. , 1976, British heart journal.

[7]  S. Vatner,et al.  Effects of isoproterenol on regional myocardial function, electrogram, and blood flow in conscious dogs with myocardial ischemia. , 1976, The Journal of clinical investigation.

[8]  J. Ross,et al.  Regional Myocardial Function in the Conscious Dog During Acute Coronary Occlusion and Responses to Morphine, Propranolol, Nitroglycerin, and Lidocaine , 1976, Circulation.

[9]  R Gorlin,et al.  Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy. , 1976, The American journal of cardiology.

[10]  M. Chatterjee,et al.  Beta adrenergic blockade in hypertension. , 1976, The Journal of the Association of Physicians of India.

[11]  M. LeWinter,et al.  Effects of oral propranolol in normal subjects. , 1976, Clinical pharmacology and therapeutics.

[12]  H. Schelbert,et al.  Left Ventricular Performance Assessed by Radionuclide Angiocardiography and Echocardiography in Patients with Previous Myocardial Infarction , 1975, Circulation.

[13]  C. Chidsey,et al.  Correlation of Plasma Propranolol Concentration with Therapeutic Response in Patients with Angina Pectoris , 1975, Circulation.

[14]  R. Dinsmore,et al.  Left Ventricular Wall Motion Response to Intravenous Propranolol , 1975, Circulation.

[15]  P. Kligfield,et al.  Noninvasive assessment of clinical response to oral propranolol therapy. , 1975, The American journal of cardiology.

[16]  H R Schelbert,et al.  Nontraumatic determination of left ventricular ejection fraction by radionuclide angiocardiography. , 1975, Circulation.

[17]  D. Harrison,et al.  Effect of propranolol on left ventricular function, segmental wall motion, and diastolic pressure-volume relation in man. , 1975, British heart journal.

[18]  D. Shand.  Drug therapy: Propranolol. , 1975, The New England journal of medicine.

[19]  P. Steele,et al.  Measurement of left heart ejection fraction and end-diastolic volume by a computerized, scintigraphic technique using a wedged pulmonary arterial catheter. , 1974, The American journal of cardiology.

[20]  S. Ayres,et al.  Propranolol in the Treatment of Acute Myocardial Infarction: Effect on Myocardial Oxygenation and Hemodynamics , 1974, Circulation.

[21]  D. Donald,et al.  Circulation Research an Official Journal of the American Heart Association Brief Reviews Myocardial Performance after Excision of the Extrinsic Cardiac Nerves in the Dog , 2022 .

[22]  D. Brutsaert,et al.  Cardiac muscle mechanics in the evaluation of myocardial contractility and pump function: problems, concepts, and directions. , 1973, Progress in cardiovascular diseases.

[23]  D. Greenblatt,et al.  Adverse reactions to propranolol in hospitalized medical patients: a report from the Boston Collaborative Drug Surveillance Program. , 1973, American heart journal.

[24]  H. Anger,et al.  Cardiac evaluation from radioisotope dynamics. , 1972, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[25]  R. Tarazi,et al.  Beta adrenergic blockade in hypertension. Practical and theoretical implications of long-term hemodynamic variations. , 1972, The American journal of cardiology.

[26]  R. Helfant,et al.  Abnormalities of Left Ventricular Contraction Induced by Beta Adrenergic Blockade , 1971, Circulation.

[27]  J. Covell,et al.  Factors Influencing Infarct Size Following Experimental Coronary Artery Occlusions , 1971, Circulation.

[28]  J. Oates,et al.  Plasma propranolol levels in adults With observations in four children , 1970, Clinical pharmacology and therapeutics.

[29]  R. Gorlin,et al.  Cardiovascular Pharmacology of Propranolol in Man , 1969, Circulation.

[30]  J. W. Cox,et al.  Hemodynamic Effects of Nitroglycerin, Propranolol, and Their Combination in Coronary Heart Disease , 1969, Circulation.

[31]  J. Parker,et al.  Hemodynamic effects of propranolol in coronary heart disease. , 1968, The American journal of cardiology.

[32]  R. Bing,et al.  A Comparative Study of Nitroglycerin and Propranolol , 1967, Circulation.

[33]  E. Sonnenblick,et al.  Cardiac Norepinephrine Stores and the Contractile State of Heart Muscle , 1966, Circulation research.

[34]  J F Williams,et al.  Effects of exercise on myocardial force-velocity relations in intact unanesthetized man: relative roles of changes in heart rate, sympathetic activity, and ventricular dimensions. , 1965, The Journal of clinical investigation.