Episodic Memory in Amnestic Mild Cognitive Impairment (aMCI) and Alzheimer’s Disease Dementia (ADD): Using the “Doors and People” Tool to Differentiate between Early aMCI—Late aMCI—Mild ADD Diagnostic Groups

Episodic memory is the type of memory that allows the recollection of personal experiences containing information on what has happened and, also, where and when it happened. Because of its sensitivity to neurodegenerative diseases and the aging of the brain, it is considered a hallmark of Alzheimer’s disease dementia (ADD). The objective of the present study was to examine episodic memory in amnestic mild cognitive impairment (aMCI) and ADD. Patients with the diagnosis of early aMCI, late aMCI, and mild ADD were evaluated using the Doors and People tool which consists of four subtests examining different aspects of episodic memory. The statistical analysis with receiver operating characteristic curves (ROC) showed the discriminant potential and the cutoffs of every subtest. Overall, the evaluation of episodic memory with the Doors and People tool can discriminate with great sensitivity between the different groups of people with AD and, especially, early aMCI, late aMCI, and mild ADD patients.

[1]  Bruna Fulgencio Dias,et al.  Episodic memory in normal and pathological aging at the RAVLT Test: Comparisons of immediate and delayed recall. , 2021, Psychology & Neuroscience.

[2]  A. Moustafa,et al.  Harnessing forgetfulness: can episodic-memory tests predict early Alzheimer’s disease? , 2021, Experimental Brain Research.

[3]  J. Razani,et al.  Differences between episodic and semantic memory in predicting observation-based activities of daily living in mild cognitive impairment and Alzheimer’s disease , 2021, Applied neuropsychology. Adult.

[4]  M. Tsolaki,et al.  Rey Complex Figure Test (RCFT): Norms for the Greek older adult population , 2020, Applied neuropsychology. Adult.

[5]  D. Dickson,et al.  The neuropathological diagnosis of Alzheimer’s disease , 2019, Molecular Neurodegeneration.

[6]  Á. Ruibal,et al.  Staging the cognitive continuum in prodromal Alzheimer's disease with episodic memory , 2019, Neurobiology of Aging.

[7]  H. Lim,et al.  Differential Associations Between Volumes of Atrophic Cortical Brain Regions and Memory Performances in Early and Late Mild Cognitive Impairment , 2019, Front. Aging Neurosci..

[8]  A. Sinclair,et al.  Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype , 2019, Alzheimer's & Dementia.

[9]  A. Ekstrom,et al.  A contextual binding theory of episodic memory: systems consolidation reconsidered , 2019, Nature Reviews Neuroscience.

[10]  Carrie R. McDonald,et al.  Early versus late MCI: Improved MCI staging using a neuropsychological approach , 2019, Alzheimer's & Dementia.

[11]  C. Caltagirone,et al.  Predicting progression to Alzheimer’s disease in subjects with amnestic mild cognitive impairment using performance on recall and recognition tests , 2018, Journal of Neurology.

[12]  T. Vangberg,et al.  The relation of hippocampal subfield volumes to verbal episodic memory measured by the California Verbal Learning Test II in healthy adults , 2018, Behavioural Brain Research.

[13]  D. Mann,et al.  Scores Obtained from a Simple Cognitive Test of Visuospatial Episodic Memory Performed Decades before Death Are Associated with the Ultimate Presence of Alzheimer Disease Pathology , 2018, Dementia and Geriatric Cognitive Disorders.

[14]  C. Marra,et al.  Predicting progression of amnesic MCI: The integration of episodic memory impairment with perfusion SPECT , 2018, Psychiatry Research: Neuroimaging.

[15]  Benjamin R. Geib,et al.  From hippocampus to whole‐brain: The role of integrative processing in episodic memory retrieval , 2017, Human brain mapping.

[16]  Jinah Park,et al.  Morphological and Microstructural Changes of the Hippocampus in Early MCI: A Study Utilizing the Alzheimer's Disease Neuroimaging Initiative Database , 2017, Journal of clinical neurology.

[17]  P. Rossini,et al.  CSF Beta-Amyloid and APOE E4 Related Decline in Episodic Memory over 12 months measured using the CANTAB in individuals with amnestic MCI: Results from the European-ADNI study , 2016 .

[18]  P. Rossini,et al.  PT593. CSF Beta-Amyloid and APOE E4 Related Decline in Episodic Memory over 12 months measured using the CANTAB in individuals with amnestic MCI: Results from the European-ADNI study , 2016, International Journal of Neuropsychopharmacology.

[19]  P. Vogazianos,et al.  Normative Data of the Montreal Cognitive Assessment in the Greek Population and Parkinsonian Dementia. , 2016, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[20]  T. Shallice,et al.  The Doors and People Test: The Effect of Frontal Lobe Lesions on Recall and Recognition Memory Performance , 2016, Neuropsychology.

[21]  G. Winocur,et al.  Episodic Memory and Beyond: The Hippocampus and Neocortex in Transformation. , 2016, Annual review of psychology.

[22]  A. Economou,et al.  Episodic Memory in Alzheimer Disease, Frontotemporal Dementia, and Dementia With Lewy Bodies/Parkinson Disease Dementia: Disentangling Retrieval From Consolidation , 2016, Alzheimer disease and associated disorders.

[23]  C. Marra,et al.  Usefulness of an Integrated Analysis of Different Memory Tasks to Predict the Progression from Mild Cognitive Impairment to Alzheimer's Disease: The Episodic Memory Score (EMS). , 2015, Journal of Alzheimer's disease : JAD.

[24]  S. Lithfous,et al.  Episodic memory in normal aging and Alzheimer disease: Insights from imaging and behavioral studies , 2015, Ageing Research Reviews.

[25]  R. Guerreiro,et al.  The age factor in Alzheimer’s disease , 2015, Genome Medicine.

[26]  L. Nyberg,et al.  Free Recall Episodic Memory Performance Predicts Dementia Ten Years prior to Clinical Diagnosis: Findings from the Betula Longitudinal Study , 2015, Dementia and Geriatric Cognitive Disorders Extra.

[27]  D. Facal,et al.  Do the Cambridge Neuropsychological Test Automated Battery episodic memory measures discriminate amnestic mild cognitive impairment? , 2014, International journal of geriatric psychiatry.

[28]  Peter Schönknecht,et al.  Episodic autobiographical memory in normal aging and mild cognitive impairment: A population-based study , 2012, Psychiatry Research.

[29]  T. Goldberg,et al.  Utility of combinations of biomarkers, cognitive markers, and risk factors to predict conversion from mild cognitive impairment to Alzheimer disease in patients in the Alzheimer's disease neuroimaging initiative. , 2011, Archives of general psychiatry.

[30]  J. Cwikel,et al.  Analysis of Memory Deficits Following Chemotherapy in Breast Cancer Survivors: Evidence from the Doors and People Test , 2011, Journal of psychosocial oncology.

[31]  Muireann Irish,et al.  Everyday episodic memory in amnestic mild cognitive impairment: a preliminary investigation , 2011, BMC Neuroscience.

[32]  Eric Guedj,et al.  Long-term consolidation of declarative memory: insight from temporal lobe epilepsy. , 2011, Brain : a journal of neurology.

[33]  Bradford C. Dickerson,et al.  Fractionating verbal episodic memory in Alzheimer's disease , 2011, NeuroImage.

[34]  Olivier Felician,et al.  Visual recognition memory: A double anatomo‐functional dissociation , 2010, Hippocampus.

[35]  A. Dale,et al.  Brain substrates of learning and retention in mild cognitive impairment diagnosis and progression to Alzheimer's disease , 2010, Neuropsychologia.

[36]  C. Lionis,et al.  The Short Anxiety Screening Test in Greek: translation and validation , 2010, Annals of general psychiatry.

[37]  Julia D. I. Meuwese,et al.  Advantages of the multiple case series approach to the study of cognitive deficits in autism spectrum disorder , 2009, Neuropsychologia.

[38]  Yufeng Zang,et al.  Abnormal Functional Connectivity of Hippocampus During Episodic Memory Retrieval Processing Network in Amnestic Mild Cognitive Impairment , 2009, Biological Psychiatry.

[39]  Raúl San José Estépar,et al.  Diffusion tractography of the fornix in schizophrenia , 2009, Schizophrenia Research.

[40]  M. Erb,et al.  Neural correlates of verbal episodic memory in patients with MCI and Alzheimer's disease––a VBM study , 2008, International journal of geriatric psychiatry.

[41]  S. Papageorgiou,et al.  A Normative Study of the Trail Making Test A and B in Greek Adults , 2008, The Clinical neuropsychologist.

[42]  L. Siegel,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2008 .

[43]  Carlo Caltagirone,et al.  Amnestic mild cognitive impairment: difference of memory profile in subjects who converted or did not convert to Alzheimer's disease. , 2007, Neuropsychology.

[44]  Sonia Malefaki,et al.  Normative data and discriminant validity of Rey's Verbal Learning Test for the Greek adult population. , 2007, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[45]  A. Fleisher,et al.  Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment , 2007, Neurology.

[46]  D. Murphy,et al.  Neuropsychological functioning in adults with Asperger syndrome , 2006, Autism : the international journal of research and practice.

[47]  M. Filippi,et al.  The contribution of voxel-based morphometry in staging patients with mild cognitive impairment , 2006, Neurology.

[48]  Magda Tsolaki,et al.  Functional cognitive assessment scale (FUCAS): a new scale to assess executive cognitive function in daily life activities in patients with dementia and mild cognitive impairment , 2006, Human psychopharmacology.

[49]  Brigitte Landeau,et al.  Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: A longitudinal MRI study , 2005, NeuroImage.

[50]  C. Jack,et al.  Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment , 2004, Journal of internal medicine.

[51]  E. Tulving Episodic memory: from mind to brain. , 2002, Annual review of psychology.

[52]  M. Kosmidis,et al.  The verbal fluency task in the Greek population: Normative data, and clustering and switching strategies , 2004, Journal of the International Neuropsychological Society.

[53]  H. Soininen,et al.  Hippocampus and entorhinal cortex in mild cognitive impairment and early AD , 2004, Neurobiology of Aging.

[54]  M. Schmitter-Edgecombe,et al.  The Ecological Validity of Neuropsychological Tests: A Review of the Literature on Everyday Cognitive Skills , 2003, Neuropsychology Review.

[55]  J. Hodges,et al.  Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment , 2003, Annals of neurology.

[56]  S. Resnick,et al.  Effects of age on virtual environment place navigation and allocentric cognitive mapping. , 2002, Behavioral neuroscience.

[57]  M. Tsolaki,et al.  Wechsler Memory Scale, Rivermead Behavioral Memory Test, and Everyday Memory Questionnaire in Healthy Adults and Alzheimer Patients , 2002 .

[58]  Magda Tsolaki,et al.  Mini Mental State Examination (MMSE): A validation study in Greece , 2000 .

[59]  M. Tsolaki,et al.  The validation of the short form of the Geriatric Depression Scale (GDS) in Greece , 1999, Aging.

[60]  R. Hess,et al.  Book Review: Doors and People: A Test of Visual and Verbal Recall and Recognition , 1999 .

[61]  R. Mohs,et al.  Alzheimer's Disease Assessment Scale: the validation of the scale in Greece in elderly demented patients and normal subjects. , 1997, Dementia and geriatric cognitive disorders.

[62]  Alan D. Baddeley,et al.  Analysis of the episodic memory deficit in early Alzheimer's disease: Evidence from the doors and people test , 1996, Neuropsychologia.

[63]  A. Baddeley,et al.  Doors and People: Visual and verbal memory after unilateral temporal lobectomy. , 1995 .

[64]  J. Hanley,et al.  The meaning and use of the area under a receiver operating characteristic (ROC) curve. , 1982, Radiology.

[65]  J. Schulz,et al.  Specific and disease stage-dependent episodic memory-related brain activation patterns in Alzheimer’s disease: a coordinate-based meta-analysis , 2014, Brain Structure and Function.

[66]  Helge Malmgren,et al.  A combination of neuropsychological, neuroimaging, and cerebrospinal fluid markers predicts conversion from mild cognitive impairment to dementia. , 2013, Journal of Alzheimer's disease : JAD.

[67]  H. Eichenbaum,et al.  The Episodic Memory System: Neurocircuitry and Disorders , 2010, Neuropsychopharmacology.

[68]  A. Baddeley,et al.  The essential handbook of memory disorders for clinicians , 2004 .

[69]  A. Collins The Psychology of Memory. , 2001 .

[70]  J. Gabrieli,et al.  Age-related changes in memory: A cognitive neuroscience perspective. , 2000 .