Lipophilicity of amphoteric and zwitterionic compounds: A comparative study of determination methods.

[1]  E. Bosch,et al.  High-throughput logPo/w determination from UHPLC measurements: Revisiting the chromatographic hydrophobicity index. , 2016, Journal of pharmaceutical and biomedical analysis.

[2]  J. Beltrán,et al.  Dissociation Constants and Octanol–Water Partition Equilibria for Several Fluoroquinolones , 2015 .

[3]  Víctor Segarra,et al.  Setup and validation of shake-flask procedures for the determination of partition coefficients (logD) from low drug amounts. , 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[4]  Rosalia Pascual,et al.  Evaluation of log Po/w values of drugs from some molecular structure calculation software , 2014 .

[5]  Joan M Cabot,et al.  High throughput determination log Po/w/pKa/log Do/w of drugs by combination of UHPLC and CE methods , 2014 .

[6]  E. Bosch,et al.  The contribution of the hydrogen bond acidity on the lipophilicity of drugs estimated from chromatographic measurements. , 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[7]  E. Bosch,et al.  Chromatographic hydrophobicity index: pH profile for polyprotic compounds. , 2009, Journal of chromatography. A.

[8]  Raimund Mannhold,et al.  Large‐Scale Evaluation of log P Predictors: Local Corrections May Compensate Insufficient Accuracy and Need of Experimentally Testing Every Other Compound , 2009, Chemistry & biodiversity.

[9]  E. Bosch,et al.  On the Effect of Organic Solvent Composition on the pH of Buffered HPLC Mobile Phases and the pK a of Analytes—A Review , 2007 .

[10]  Alex Avdeef,et al.  Absorption and Drug Development: Solubility, Permeability, and Charge State , 2003 .

[11]  A. Hill,et al.  Retention of ionizable compounds on HPLC. 8. Influence of mobile-phase pH change on the chromatographic retention of acids and bases during gradient elution. , 2001, Analytical chemistry.

[12]  M. Abraham,et al.  Rapid method for the estimation of octanol/water partition coefficient (log P(oct)) from gradient RP-HPLC retention and a hydrogen bond acidity term (zetaalpha(2)(H)). , 2001, Current medicinal chemistry.

[13]  Kin Yip Tam,et al.  Multi-wavelength spectrophotometric determination of acid dissociation constants: a validation study , 2001 .

[14]  D. Cairns Essentials of Pharmaceutical Chemistry , 2000 .

[15]  C. Bevan,et al.  Chromatographic Hydrophobicity Index by Fast-Gradient RP-HPLC:  A High-Throughput Alternative to log P/log D. , 1997, Analytical chemistry.

[16]  A. Avdeef,et al.  pH-metric log P. II: Refinement of partition coefficients and ionization constants of multiprotic substances. , 1993, Journal of pharmaceutical sciences.

[17]  E. Bosch,et al.  High-throughput log P o / w determination from UHPLC measurements : 1 revisiting the Chromatographic Hydrophobicity Index 2 , 2016 .

[18]  E. Bosch,et al.  Chromatographic Hydrophobicity Index (CHI). , 2012, Advances in chromatography.

[19]  R. Lobrutto Retention of Ionizable Compounds in HPLC , 2000 .

[20]  John Comer,et al.  pH-Metric log P. 3. Glass electrode calibration in methanol-water, applied to pKa determination of water-insoluble substances , 1993 .

[21]  Alex Avdeef,et al.  pH‐Metric log P. Part 1. Difference Plots for Determining Ion‐Pair Octanol‐Water Partition Coefficients of Multiprotic Substances , 1992 .