Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway.

[1]  S. Cuzzocrea,et al.  Correction: Effect of a new formulation of micronized and ultramicronized N-palmitoylethanolamine in a tibia fracture mouse model of complex regional pain syndrome , 2018, PloS one.

[2]  Conor D. Cox,et al.  Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus , 2018, Cerebral cortex.

[3]  V. Neugebauer,et al.  Amygdala Plasticity and Pain , 2017, Pain research & management.

[4]  Marina Flaibani,et al.  mTOR-Dependent Cell Proliferation in the Brain , 2017, BioMed research international.

[5]  M. Grilli Chronic pain and adult hippocampal neurogenesis: translational implications from preclinical studies , 2017, Journal of pain research.

[6]  Yu Kyeong Kim,et al.  Upregulation of prefrontal metabotropic glutamate receptor 5 mediates neuropathic pain and negative mood symptoms after spinal nerve injury in rats , 2017, Scientific Reports.

[7]  Anna L. Blobaum,et al.  mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome , 2017, Science Translational Medicine.

[8]  D. Centonze,et al.  A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum , 2017, Scientific Reports.

[9]  H. Lester,et al.  TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus , 2017, Nature Communications.

[10]  F. Piscitelli,et al.  Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor , 2017, Scientific Reports.

[11]  M. Cha,et al.  Inhibition of Mammalian Target of Rapamycin (mTOR) Signaling in the Insular Cortex Alleviates Neuropathic Pain after Peripheral Nerve Injury , 2017, Front. Mol. Neurosci..

[12]  F. Rossi,et al.  Palmitoylethanolamide Reduces Neuropsychiatric Behaviors by Restoring Cortical Electrophysiological Activity in a Mouse Model of Mild Traumatic Brain Injury , 2017, Front. Pharmacol..

[13]  V. Marzo,et al.  Formation of OX-1R/CB1R heteromeric complexes in embryonic mouse hypothalamic cells: Effect on intracellular calcium, 2-arachidonoyl-glycerol biosynthesis and ERK phosphorylation. , 2016, Pharmacological research.

[14]  Gary Lynch,et al.  A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation , 2016, eNeuro.

[15]  M. Zhuo,et al.  Metabotropic Glutamate Receptor Dependent Cortical Plasticity in Chronic Pain , 2016, Current neuropharmacology.

[16]  S. Rajagopal,et al.  The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors* , 2016, The Journal of Biological Chemistry.

[17]  T. Banke Inhibition of TRPV1 channels enables long-term potentiation in the entorhinal cortex , 2016, Pflügers Archiv - European Journal of Physiology.

[18]  A. Usiello,et al.  Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice , 2015, Molecular Brain.

[19]  S. Cuzzocrea,et al.  Antineuropathic Profile of N-Palmitoylethanolamine in a Rat Model of Oxaliplatin-Induced Neurotoxicity , 2015, PloS one.

[20]  Giorgio A Ascoli,et al.  Quantitative Investigations of Axonal and Dendritic Arbors , 2015, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[21]  R. Citraro,et al.  Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice , 2015, Molecular metabolism.

[22]  R. Kuner Spinal excitatory mechanisms of pathological pain. , 2015, Pain.

[23]  D. De Gregorio,et al.  MMPIP, an mGluR7-selective negative allosteric modulator, alleviates pain and normalizes affective and cognitive behavior in neuropathic mice , 2015, Pain.

[24]  Jufang He,et al.  Time course of the dependence of associative memory retrieval on the entorhinal cortex , 2014, Neurobiology of Learning and Memory.

[25]  R. Huganir,et al.  Postsynaptic insertion of AMPA receptor onto cortical pyramidal neurons in the anterior cingulate cortex after peripheral nerve injury , 2014, Molecular Brain.

[26]  Fengyu Liu,et al.  Exacerbation of tonic but not phasic pain by entorhinal cortex lesions , 2014, Neuroscience Letters.

[27]  Paul D. Morton,et al.  Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling , 2014, Brain, Behavior, and Immunity.

[28]  D. De Gregorio,et al.  Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions. , 2014, Journal of neurophysiology.

[29]  Neil Burgess,et al.  What do grid cells contribute to place cell firing? , 2014, Trends in Neurosciences.

[30]  Livio Luongo,et al.  Endocannabinoids and neuropathic pain: focus on neuron–glia and endocannabinoid–neurotrophin interactions , 2014, The European journal of neuroscience.

[31]  R. Dantzer,et al.  Neuroinflammation and Comorbidity of Pain and Depression , 2014, Pharmacological Reviews.

[32]  C. Breivogel,et al.  The influence of beta-arrestin2 on cannabinoid CB1 receptor coupling to G-proteins and subcellular localization and relative levels of beta-arrestin1 and 2 in mouse brain , 2013, Journal of receptor and signal transduction research.

[33]  Giorgio Cruccu,et al.  Reappraising neuropathic pain in humans—how symptoms help disclose mechanisms , 2013, Nature Reviews Neurology.

[34]  Seralynne D Vann,et al.  Dismantling the Papez circuit for memory in rats , 2013, eLife.

[35]  G. Busetto,et al.  Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons , 2013, Proceedings of the National Academy of Sciences.

[36]  S. Maione,et al.  Effects of a metabotropic glutamate receptor subtype 7 negative allosteric modulator in the periaqueductal grey on pain responses and rostral ventromedial medulla cell activity in rat , 2013, Molecular pain.

[37]  Jun Chen,et al.  The mTOR signaling pathway regulates pain-related synaptic plasticity in rat entorhinal-hippocampal pathways , 2013, Molecular Pain.

[38]  D. Siniscalco,et al.  TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception. , 2012, Cerebral cortex.

[39]  Luke A Henderson,et al.  Pain and Plasticity: Is Chronic Pain Always Associated with Somatosensory Cortex Activity and Reorganization? , 2012, The Journal of Neuroscience.

[40]  R. Meli,et al.  Palmitoylethanolamide Protects Against the Amyloid-β25-35-Induced Learning and Memory Impairment in Mice, an Experimental Model of Alzheimer Disease , 2012, Neuropsychopharmacology.

[41]  Jelena Radulovic,et al.  Abnormalities in Hippocampal Functioning with Persistent Pain , 2012, The Journal of Neuroscience.

[42]  D. Piomelli,et al.  2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism. , 2012, Cell metabolism.

[43]  S. Maione,et al.  Changes in cannabinoid receptor subtype 1 activity and interaction with metabotropic glutamate subtype 5 receptors in the periaqueductal gray-rostral ventromedial medulla pathway in a rodent neuropathic pain model. , 2012, CNS & neurological disorders drug targets.

[44]  L. Kerbauy,et al.  Effect of isolation rearing on the expression of AMPA glutamate receptors in the hippocampal formation , 2011, Journal of psychopharmacology.

[45]  M. Barrot,et al.  A Time-Dependent History of Mood Disorders in a Murine Model of Neuropathic Pain , 2011, Biological Psychiatry.

[46]  T. Bisogno,et al.  Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice , 2011, Nutrition & metabolism.

[47]  Jun Wang,et al.  Peripheral Nerve Injury Leads to Working Memory Deficits and Dysfunction of the Hippocampus by Upregulation of TNF-α in Rodents , 2011, Neuropsychopharmacology.

[48]  J. Wojtowicz,et al.  Analyzing Dendritic Growth in a Population of Immature Neurons in the Adult Dentate Gyrus Using Laminar Quantification of Disjointed Dendrites , 2011, Front. Neurosci..

[49]  D. Finn,et al.  The effect of pain on cognitive function: A review of clinical and preclinical research , 2011, Progress in Neurobiology.

[50]  O. von Bohlen und Halbach,et al.  Capsaicin-Induced Changes in LTP in the Lateral Amygdala Are Mediated by TRPV1 , 2011, PloS one.

[51]  F. Rossi,et al.  The Role of Cannabinoid Receptors in the Descending Modulation of Pain , 2010, Pharmaceuticals.

[52]  S. Petrosino,et al.  N-palmitoyl-ethanolamine: Biochemistry and new therapeutic opportunities. , 2010, Biochimie.

[53]  J. Wierońska,et al.  Metabotropic glutamate receptors in the tripartite synapse as a target for new psychotropic drugs , 2009, Neurochemistry International.

[54]  A. Hohmann,et al.  The endocannabinoid system and pain. , 2009, CNS & neurological disorders drug targets.

[55]  K. Svoboda,et al.  Experience-dependent structural synaptic plasticity in the mammalian brain , 2009, Nature Reviews Neuroscience.

[56]  G. Godlewski,et al.  Receptors for acylethanolamides-GPR55 and GPR119. , 2009, Prostaglandins & other lipid mediators.

[57]  I. Izquierdo,et al.  BDNF is essential to promote persistence of long-term memory storage , 2008, Proceedings of the National Academy of Sciences.

[58]  B. Cravatt,et al.  A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2‐Arachidonoylglycerol , 2007, Chemistry & biology.

[59]  A. Bilbao,et al.  Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain , 2007, PAIN®.

[60]  M. Tanabe,et al.  Altered hippocampal long-term potentiation after peripheral nerve injury in mice. , 2007, European journal of pharmacology.

[61]  S. Hjorth,et al.  The orphan receptor GPR55 is a novel cannabinoid receptor , 2007, British journal of pharmacology.

[62]  F. Holsboer,et al.  Reduced Anxiety, Conditioned Fear, and Hippocampal Long-Term Potentiation in Transient Receptor Potential Vanilloid Type 1 Receptor-Deficient Mice , 2007, The Journal of Neuroscience.

[63]  A. Hohmann,et al.  Rapid Broad-Spectrum Analgesia through Activation of Peroxisome Proliferator-Activated Receptor-α , 2006, Journal of Pharmacology and Experimental Therapeutics.

[64]  E. Kandel,et al.  Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus , 2006, Proceedings of the National Academy of Sciences.

[65]  Robert J. Lefkowitz,et al.  G-protein-coupled Receptor Kinase Specificity for β-Arrestin Recruitment to the β2-Adrenergic Receptor Revealed by Fluorescence Resonance Energy Transfer* , 2006, Journal of Biological Chemistry.

[66]  T. Freund,et al.  Molecular Composition of the Endocannabinoid System at Glutamatergic Synapses , 2006, The Journal of Neuroscience.

[67]  Michael Häusser,et al.  Dendritic Calcium Spikes Are Tunable Triggers of Cannabinoid Release and Short-Term Synaptic Plasticity in Cerebellar Purkinje Neurons , 2006, The Journal of Neuroscience.

[68]  C. Guaza,et al.  Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures , 2005, Glia.

[69]  Masanobu Kano,et al.  Synaptically Driven Endocannabinoid Release Requires Ca2+-Assisted Metabotropic Glutamate Receptor Subtype 1 to Phospholipase C β4 Signaling Cascade in the Cerebellum , 2005, The Journal of Neuroscience.

[70]  David Attwell,et al.  Endocannabinoid signaling depends on the spatial pattern of synapse activation , 2005, Nature Neuroscience.

[71]  D. Piomelli,et al.  The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide , 2005, Molecular Pharmacology.

[72]  Su-Jane Wang Cannabinoid CB1 receptor-mediated inhibition of glutamate release from rat hippocampal synaptosomes. , 2003, European journal of pharmacology.

[73]  R. Melzack,et al.  Blocking NMDA Receptors in the Hippocampal Dentate Gyrus with AP5 Produces Analgesia in the Formalin Pain Test , 2001, Experimental Neurology.

[74]  L. Berrino,et al.  Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception , 2001, Neuropharmacology.

[75]  C. Woolf,et al.  Spared nerve injury: an animal model of persistent peripheral neuropathic pain , 2000, Pain.

[76]  F. J. van der Staay,et al.  Behavioral effects of apamin, a selective inhibitor of the SKCa-channel, in mice and rats , 1999, Neuroscience & Biobehavioral Reviews.

[77]  S. Ikonen,et al.  Effects of apamin on memory processing of hippocampal-lesioned mice. , 1999, European journal of pharmacology.

[78]  D. Jane,et al.  Pharmacological agents acting at subtypes of metabotropic glutamate receptors , 1999, Neuropharmacology.

[79]  S. Yamamoto,et al.  Anandamide amidohydrolase reacting with 2‐arachidonoylglycerol, another cannabinoid receptor ligand , 1998, FEBS letters.

[80]  H J Gundersen,et al.  The efficiency of systematic sampling in stereology and its prediction * , 1987, Journal of microscopy.

[81]  A. Gol,et al.  Hippocampectomy for relief of intractable pain. , 1966, Texas medicine.

[82]  S. Petrosino,et al.  Adelmidrol increases the endogenous concentrations of palmitoylethanolamide in canine keratinocytes and down-regulates an inflammatory reaction in an in vitro model of contact allergic dermatitis. , 2016, Veterinary journal.

[83]  D. Finn,et al.  Impaired recognition memory and cognitive flexibility in the rat L5–L6 spinal nerve ligation model of neuropathic pain , 2016, Scandinavian journal of pain.

[84]  E. Kandel,et al.  Structural changes accompanying memory storage. , 1993, Annual review of physiology.