Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs

[1]  Tom A P Driedonks,et al.  Circulating Y-RNAs in Extracellular Vesicles and Ribonucleoprotein Complexes; Implications for the Immune System , 2019, Front. Immunol..

[2]  Sara R. Selitsky,et al.  Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma , 2018, The Journal of clinical investigation.

[3]  M. Kaplan,et al.  Cardiovascular disease in systemic lupus erythematosus: an update , 2018, Current opinion in rheumatology.

[4]  G. Bhanot,et al.  Endogenous retrovirus expression is associated with response to immune checkpoint blockade in clear cell renal cell carcinoma. , 2018, JCI insight.

[5]  D. D. De Carvalho,et al.  Deregulation of Retroelements as an Emerging Therapeutic Opportunity in Cancer. , 2018, Trends in cancer.

[6]  G. Freeman,et al.  LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade , 2018, Cell.

[7]  P. Tamayo,et al.  Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses , 2018, Nature Medicine.

[8]  S. Sozzani,et al.  Exosome-delivered microRNAs promote IFN-α secretion by human plasmacytoid DCs via TLR7. , 2018, JCI insight.

[9]  R. Slotkin,et al.  The case for not masking away repetitive DNA , 2018, Mobile DNA.

[10]  Nir Hacohen,et al.  Systems Immunology: Learning the Rules of the Immune System. , 2018, Annual review of immunology.

[11]  M. Gale,et al.  RIG-I and Other RNA Sensors in Antiviral Immunity. , 2018, Annual review of immunology.

[12]  Cheng-Zhong Zhang,et al.  Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation , 2018, Cell.

[13]  Brian Bushnell,et al.  BBMerge – Accurate paired shotgun read merging via overlap , 2017, PloS one.

[14]  A. Lichtman,et al.  Monocyte-Macrophages and T Cells in Atherosclerosis. , 2017, Immunity.

[15]  S. Tas,et al.  Endothelial cells: From innocent bystanders to active participants in immune responses. , 2017, Autoimmunity reviews.

[16]  J. V. Moran,et al.  Mobile DNA in Health and Disease , 2017, The New England journal of medicine.

[17]  B. Nabet,et al.  Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer , 2017, Cell.

[18]  Richard J. Johnson,et al.  Role of the Immune System in Hypertension. , 2017, Physiological reviews.

[19]  Mark M. Davis,et al.  Systems immunology: just getting started , 2017, Nature Immunology.

[20]  D. Bajorin,et al.  Global Cancer Transcriptome Quantifies Repeat Element Polarization between Immunotherapy Responsive and T Cell Suppressive Classes , 2017, bioRxiv.

[21]  Elizabeth E Gray,et al.  Intracellular Nucleic Acid Detection in Autoimmunity. , 2017, Annual review of immunology.

[22]  H. Cardinal,et al.  The Emerging Importance of Non-HLA Autoantibodies in Kidney Transplant Complications. , 2017, Journal of the American Society of Nephrology : JASN.

[23]  R. Simpson,et al.  Transcriptome and long noncoding RNA sequencing of three extracellular vesicle subtypes released from the human colon cancer LIM1863 cell line , 2016, Scientific Reports.

[24]  Toshiyuki Shimizu,et al.  Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA. , 2016, Immunity.

[25]  Simon C Watkins,et al.  Donor dendritic cell-derived exosomes promote allograft-targeting immune response. , 2016, The Journal of clinical investigation.

[26]  J. Markmann,et al.  Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation , 2016, Science Immunology.

[27]  V. Hornung,et al.  Recognition of Endogenous Nucleic Acids by the Innate Immune System. , 2016, Immunity.

[28]  Lior Pachter,et al.  Near-optimal probabilistic RNA-seq quantification , 2016, Nature Biotechnology.

[29]  L. Zitvogel,et al.  Dendritic cell-derived exosomes for cancer therapy. , 2016, The Journal of clinical investigation.

[30]  C. Harding,et al.  Extracellular vesicles and infectious diseases: new complexity to an old story. , 2016, The Journal of clinical investigation.

[31]  P. Robbins,et al.  Regulation of chronic inflammatory and immune processes by extracellular vesicles. , 2016, The Journal of clinical investigation.

[32]  Laurence Zitvogel,et al.  Extracellular vesicles: masters of intercellular communication and potential clinical interventions. , 2016, The Journal of clinical investigation.

[33]  J. Stoye,et al.  Immune responses to endogenous retroelements: taking the bad with the good , 2016, Nature Reviews Immunology.

[34]  S. Akira,et al.  Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs , 2016, Oncotarget.

[35]  Clotilde Théry,et al.  Communication by Extracellular Vesicles: Where We Are and Where We Need to Go , 2016, Cell.

[36]  Gajendra P. S. Raghava,et al.  Prediction of Immunomodulatory potential of an RNA sequence for designing non-toxic siRNAs and RNA-based vaccine adjuvants , 2016, Scientific Reports.

[37]  N. Vabret,et al.  Innate immune system activation by viral RNA: How to predict it? , 2016, Virology.

[38]  X. Mu,et al.  Endogenous Retroelements and the Host Innate Immune Sensors. , 2016, Advances in immunology.

[39]  François Major,et al.  Exploring Alternative RNA Structure Sets Using MC-Flashfold and db2cm. , 2016, Methods in molecular biology.

[40]  A. Lau,et al.  The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection , 2015, Science Translational Medicine.

[41]  M. Beckmann,et al.  Abstract B32: Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses , 2016 .

[42]  Trevor J Pugh,et al.  DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts , 2015, Cell.

[43]  H. Fox,et al.  MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease , 2015, PLoS pathogens.

[44]  Steven L Salzberg,et al.  HISAT: a fast spliced aligner with low memory requirements , 2015, Nature Methods.

[45]  H. Rabb,et al.  Immune cells in experimental acute kidney injury , 2015, Nature Reviews Nephrology.

[46]  M. Gelb,et al.  Detection and Quantification of Microparticles from Different Cellular Lineages Using Flow Cytometry. Evaluation of the Impact of Secreted Phospholipase A2 on Microparticle Assessment , 2015, PloS one.

[47]  K. Ohyashiki,et al.  Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1. , 2014, Blood.

[48]  George A Calin,et al.  Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. , 2014, Cancer cell.

[49]  H. Ishwaran,et al.  Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways , 2014, Cell.

[50]  B. Ylstra,et al.  Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes. , 2014, Cell reports.

[51]  J. Ritz,et al.  Current issues in chronic graft-versus-host disease. , 2014, Blood.

[52]  C. Perou,et al.  Comparison of RNA-Seq by poly (A) capture, ribosomal RNA depletion, and DNA microarray for expression profiling , 2014, BMC Genomics.

[53]  E. Levanon,et al.  Genome-wide analysis of Alu editability , 2014, Nucleic acids research.

[54]  Mark D. Robinson,et al.  Robustly detecting differential expression in RNA sequencing data using observation weights , 2013, Nucleic acids research.

[55]  Ernesto Picardi,et al.  REDItools: high-throughput RNA editing detection made easy , 2013, Bioinform..

[56]  P. Thibault,et al.  A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells , 2013, Proteomics.

[57]  C. Cameron,et al.  Native Tertiary Structure and Nucleoside Modifications Suppress tRNA’s Intrinsic Ability to Activate the Innate Immune Sensor PKR , 2013, PloS one.

[58]  C. Roufosse,et al.  Microcirculation Inflammation Associates With Outcome in Renal Transplant Patients With De Novo Donor‐Specific Antibodies , 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[59]  J. Kahlenberg,et al.  Mechanisms of premature atherosclerosis in rheumatoid arthritis and lupus. , 2013, Annual review of medicine.

[60]  Roberta Galli,et al.  MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response , 2012, Proceedings of the National Academy of Sciences.

[61]  P. Deininger.  Alu elements: know the SINEs , 2011, Genome Biology.

[62]  Pedro L. Fernandes,et al.  Report of the EMBnet AGM 2011 Workshop , 2011 .

[63]  T. Luft,et al.  Steroid-refractory GVHD: T-cell attack within a vulnerable endothelial system. , 2011, Blood.

[64]  Marcel Martin.  Cutadapt removes adapter sequences from high-throughput sequencing reads , 2011 .

[65]  Carl Kingsford,et al.  A fast, lock-free approach for efficient parallel counting of occurrences of k-mers , 2011, Bioinform..

[66]  S. Pomeroy,et al.  Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. , 2011, Nature communications.

[67]  D. Jain,et al.  Graft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells , 2011, The Journal of Immunology.

[68]  B. Williams,et al.  Rational design of immunostimulatory siRNAs. , 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

[69]  Nicole H. Kattah,et al.  The U1‐snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases , 2010, Immunological reviews.

[70]  H. Mühl,et al.  Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA , 2009, Nucleic acids research.

[71]  F. Major,et al.  The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data , 2008, Nature.

[72]  B. Williams,et al.  TLR7 Is Involved in Sequence-Specific Sensing of Single-Stranded RNAs in Human Macrophages1 , 2008, The Journal of Immunology.

[73]  C. Pipper,et al.  [''R"--project for statistical computing]. , 2008, Ugeskrift for laeger.

[74]  M. Robinson,et al.  Small-sample estimation of negative binomial dispersion, with applications to SAGE data. , 2007, Biostatistics.

[75]  M. Teichmann,et al.  The expanding RNA polymerase III transcriptome. , 2007, Trends in genetics : TIG.

[76]  J. Jurka,et al.  Repetitive sequences in complex genomes: structure and evolution. , 2007, Annual review of genomics and human genetics.

[77]  G. Barber,et al.  Differential tissue targeting of autoimmunity manifestations by autoantigen-associated Y RNAs. , 2007, Arthritis and rheumatism.

[78]  S. Akira,et al.  Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8 , 2005, The Journal of experimental medicine.

[79]  Shizuo Akira,et al.  Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA , 2004, Science.

[80]  S. Akira,et al.  Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8 , 2004, Science.

[81]  Ravi Kumar,et al.  Structure and Evolution Of , 2004 .

[82]  Bonita Wilson,et al.  Taking the Bad with the Good , 2002, D Lib Mag..

[83]  J. Z. Shapiro.  Where We Are and Where We Need to Go , 1985 .

[84]  K. Johnson.  An Update. , 1984, Journal of food protection.