Methylenedioxy-benzopyran analogs of podophyllotoxin, a new synthetic class of antimitotic agents that inhibit tubulin polymerization.

[1]  L. Jurd Bioactive heterocyclic analogs of the antitumor drug, podophyllotoxin , 1988 .

[2]  K. Paull,et al.  In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models. , 1987, Journal of medicinal chemistry.

[3]  W. Waud,et al.  Comparison of 1,2-dihydropyrido[3,4-b]pyrazines (1-deaza-7,8-dihydropteridines) with several other inhibitors of mitosis. , 1987, Cancer research.

[4]  E. Hamel,et al.  Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum. , 1987, Journal of natural products.

[5]  E. Hamel,et al.  Morpholino derivatives of benzyl-benzodioxole, a study of structural requirements for drug interactions at the colchicine/podophyllotoxin binding site of tubulin. , 1986, Biochemical pharmacology.

[6]  L. Jurd Mannich base derivatives of bioactive benzyl-1,3-benzodioxo-5-ols , 1985 .

[7]  E. Lacey,et al.  Structure-activity relationships of benzimidazole carbamates as inhibitors of mammalian tubulin, in vitro. , 1985, Biochemical pharmacology.

[8]  E. Hamel,et al.  Deoxyguanosine nucleotide analogues: potent stimulators of microtubule nucleation with reduced affinity for the exchangeable nucleotide site of tubulin. , 1984, Biochemistry.

[9]  E. Hamel,et al.  Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles. , 1984, Biochemistry.

[10]  E. Hamel,et al.  Interactions of combretastatin, a new plant-derived antimitotic agent, with tubulin. , 1983, Biochemical pharmacology.

[11]  E. Hamel,et al.  Microtubule assembly with the guanosine 5'-diphosphate analogue 2',3'-dideoxyguanosine 5'-diphosphate. , 1983, Biochemistry.

[12]  T. Arai Inhibition of microtubule assembly in vitro by TN‐16, a synthetic antitumor drug , 1983, FEBS letters.

[13]  E. Hamel,et al.  Interactions of a new antimitotic agent, NSC-181928, with purified tubulin. , 1982, Biochemical and biophysical research communications.

[14]  L. Jurd,et al.  New types of insect chemosterilants. Benzylphenols and benzyl-1,3-benzodioxole derivatives as additives to housefly diet , 1979 .

[15]  P. Friedman,et al.  Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin. , 1978, Biochimica et biophysica acta.

[16]  P. Schiff,et al.  Steganacin: an inhibitor of HeLa cell growth and microtubule assembly in vitro. , 1978, Biochemical and biophysical research communications.

[17]  J. Loike,et al.  Structure-activity study of the inhibition of microtubule assembly in vitro by podophyllotoxin and its congeners. , 1978, Cancer research.

[18]  Thomas J. Fltzgerald Molecular features of colchicine associated with antimitotic activity and inhibition of tubulin polymerization , 1976 .

[19]  M. De Brabander,et al.  Interaction of oncodazole (R 17934), a new antitumoral drug, with rat brain tubulin. , 1976, Biochemical and biophysical research communications.

[20]  R. L. Dion,et al.  Initial studies on maytansine-induced metaphase arrest in L1210 murine leukemia cells. , 1975, Biochemical pharmacology.

[21]  C. Cantor,et al.  Turbidimetric studies of the in vitro assembly and disassembly of porcine neurotubules. , 1974, Journal of molecular biology.

[22]  G. Borisy A rapid method for quantitative determination of microtubule protein using DEAE-cellulose filters. , 1972, Analytical biochemistry.

[23]  E. Taylor,et al.  The colchicine-binding protein of mammalian brain and its relation to microtubules. , 1968, Biochemistry.