Effect of glutamine on cystine excretion in a patient with cystinuria.

SINCE Crawhall et al. reported on the use of D-penicillamine in cystinuria,1 this drug has been thought to provide the best treatment for the disease. The drug converts cystine into more soluble disulfide compounds, thus preventing the formation of calculi. During our study of amino acid reabsorption in cystinuria, glutamine was found to decrease cystine excretion by either increasing reabsorption or decreasing cystine secretion.2 This observation suggested the possible use of glutamine as an alternative to D-penicillamine for the treatment of cystinuria. Case Report A 69-year-old man was considered to have Type II cystinuria,3 because oral loads of cystine decreased . . .

[1]  S. Moore,et al.  Automatic recording apparatus for use in the chromatography of amino acids. , 1958, Federation proceedings.

[2]  J. Young,et al.  Renal tubular transport of amino acids. , 1971, Clinical chemistry.

[3]  B. Senior,et al.  STUDIES ON THE TREATMENT OF CYSTINURIA1 , 1955 .

[4]  J. L. Durant,et al.  Cystinuria: biochemical evidence for three genetically distinct diseases. , 1966, The Journal of clinical investigation.

[5]  R. Watts,et al.  Effect of Penicillamine on Cystinuria , 1963, British medical journal.