Trabecular Bone Response to Mechanical and Parathyroid Hormone Stimulation: The Role of Mechanical Microenvironment

Bone response under combined mechanical and PTH stimuli is important in osteoporosis. A rat tail animal model with computer modeling was used to examine bone response to loading and PTH. PTH enhances and sustains increased bone formation rate, which directly correlates to mechanical microenvironment, suggesting beneficial effects of combined PTH treatment and exercise in preventing osteoporosis.

[1]  C. Crandall.  Parathyroid hormone for treatment of osteoporosis. , 2002, Archives of internal medicine.

[2]  M. Karlsson,et al.  Is exercise of value in the prevention of fragility fractures in men? , 2002, Scandinavian journal of medicine & science in sports.

[3]  X. Guo,et al.  Quantification of a rat tail vertebra model for trabecular bone adaptation studies. , 2002, Journal of biomechanics.

[4]  L. Gibson,et al.  Microdamage accumulation in bovine trabecular bone in uniaxial compression. , 2002, Journal of biomechanical engineering.

[5]  J. Reginster,et al.  Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. , 2001, The New England journal of medicine.

[6]  J. Iwamoto,et al.  Effect of exercise training and detraining on bone mineral density in postmenopausal women with osteoporosis , 2001, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[7]  P Rüegsegger,et al.  Introduction and evaluation of a gray-value voxel conversion technique. , 2001, Journal of biomechanics.

[8]  R. Lindsay,et al.  Parathyroid hormone as a therapy for idiopathic osteoporosis in men: effects on bone mineral density and bone markers. , 2000, The Journal of clinical endocrinology and metabolism.

[9]  R. Duncan,et al.  Parathyroid Hormone Modulates the Response of Osteoblast-Like Cells to Mechanical Stimulation , 2000, Calcified Tissue International.

[10]  Rik Huiskes,et al.  Effects of mechanical forces on maintenance and adaptation of form in trabecular bone , 2000, Nature.

[11]  R. L. Cain,et al.  Changes in Geometry and Cortical Porosity in Adult, Ovary-Intact Rabbits after 5 Months Treatment with LY333334 (hPTH 1-34) , 2000, Calcified Tissue International.

[12]  S A Goldstein,et al.  Vertebral trabecular bone microscopic tissue elastic modulus and hardness do not change in ovariectomized rats , 2000, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[13]  G. Niebur,et al.  Convergence behavior of high-resolution finite element models of trabecular bone. , 1999, Journal of biomechanical engineering.

[14]  Toru Hirano,et al.  Anabolic Effects of Human Biosynthetic Parathyroid Hormone Fragment (1–34), LY333334, on Remodeling and Mechanical Properties of Cortical Bone in Rabbits , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[15]  P. Rüegsegger,et al.  Finite element analysis of trabecular bone structure: a comparison of image-based meshing techniques. , 1998, Journal of biomechanics.

[16]  C H Turner,et al.  Three rules for bone adaptation to mechanical stimuli. , 1998, Bone.

[17]  L E Lanyon,et al.  Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats. , 1998, Bone.

[18]  P. Rüegsegger,et al.  Morphometric analysis of human bone biopsies: a quantitative structural comparison of histological sections and micro-computed tomography. , 1998, Bone.

[19]  T. Keaveny,et al.  Yield strain behavior of trabecular bone. , 1998, Journal of biomechanics.

[20]  H. Nagashima,et al.  Bone responses at various skeletal sites to human parathyroid hormone in ovariectomized rats: effects of long-term administration, withdrawal, and readministration. , 1998, Bone.

[21]  F. Eckstein,et al.  Computer simulation of subchondral bone adaptation to mechanical loading in an incongruous joint , 1997, The Anatomical record.

[22]  J. C. Simo,et al.  Adaptive bone remodeling incorporating simultaneous density and anisotropy considerations. , 1997, Journal of biomechanics.

[23]  R Huiskes,et al.  Osteocytes and bone lining cells: which are the best candidates for mechano-sensors in cancellous bone? , 1997, Bone.

[24]  T. Takano-Yamamoto,et al.  Enhancement by conditioned medium of stretched calvarial bone cells of the osteoclast-like cell formation induced by parathyroid hormone in mouse bone marrow cultures. , 1997, Archives of oral biology.

[25]  J. Chow,et al.  Estrogen suppresses activation but enhances formation phase of osteogenic response to mechanical stimulation in rat bone. , 1996, The Journal of clinical investigation.

[26]  J. Chow,et al.  Osteocytic expression of mRNA for c-fos and IGF-I: an immediate early gene response to an osteogenic stimulus. , 1996, The American journal of physiology.

[27]  C. Turner,et al.  Mechanotransduction and the functional response of bone to mechanical strain , 1995, Calcified Tissue International.

[28]  R. Lindsay,et al.  Effects of reciprocal treatment with estrogen and estrogen plus parathyroid hormone on bone structure and strength in ovariectomized rats. , 1995, The Journal of clinical investigation.

[29]  I. Owan,et al.  Aging changes mechanical loading thresholds for bone formation in rats , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[30]  J. Zanchetta,et al.  Tomographic (pQCT) and biomechanical effects of hPTH(1-38) on chronically immobilized or overloaded rat femurs. , 1995, Bone.

[31]  R. Ziegler,et al.  Parathyroid hormone increases the concentration of insulin-like growth factor-I and transforming growth factor beta 1 in rat bone. , 1995, The Journal of clinical investigation.

[32]  R. Huiskes,et al.  Proposal for the regulatory mechanism of Wolff's law , 1995, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[33]  J. C. Simo,et al.  Numerical instabilities in bone remodeling simulations: the advantages of a node-based finite element approach. , 1995, Journal of biomechanics.

[34]  J. Chow,et al.  Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation. , 1995, The American journal of physiology.

[35]  R. Recker,et al.  Mechanical loading stimulates rapid changes in periosteal gene expression , 1994, Calcified Tissue International.

[36]  R. Carvalho,et al.  Stimulation of signal transduction pathways in osteoblasts by mechanical strain potentiated by parathyroid hormone , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[37]  N. Kikuchi,et al.  A homogenization sampling procedure for calculating trabecular bone effective stiffness and tissue level stress. , 1994, Journal of biomechanics.

[38]  S C Cowin,et al.  Bone stress adaptation models. , 1993, Journal of biomechanical engineering.

[39]  T J Chambers,et al.  Characterization of osteogenic response to mechanical stimulation in cancellous bone of rat caudal vertebrae. , 1993, The American journal of physiology.

[40]  J. Galante,et al.  ESB Research Award 1992. The mechanism of bone remodeling and resorption around press-fitted THA stems. , 1993, Journal of biomechanics.

[41]  C. Rubin,et al.  Suppression of the osteogenic response in the aging skeleton , 1992, Calcified Tissue International.

[42]  R. Huiskes.  Adaptive bone-remodeling analysis. , 1992, La Chirurgia degli Organi di Movimento.

[43]  B. Hollis,et al.  Preexisting bone loss associated with ovariectomy in rats is reversed by parathyroid hormone , 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[44]  O. Tørring,et al.  The anabolic effects of human parathyroid hormone (hPTH) on rat vertebral body mass are also reflected in the quality of bone, assessed by biomechanical testing: a comparison study between hPTH-(1-34) and hPTH-(1-84). , 1991, Endocrinology.

[45]  S. Goldstein,et al.  Evaluation of a microcomputed tomography system to study trabecular bone structure , 1990, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[46]  G S Beaupré,et al.  Computer predictions of bone remodeling around porous-coated implants. , 1990, The Journal of arthroplasty.

[47]  G. Beaupré,et al.  An approach for time‐dependent bone modeling and remodeling—application: A preliminary remodeling simulation , 1990, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[48]  K. Miyajima.  [Effect of PTH and periodic tension on osteoblast-like cells for collagenase synthesis]. , 1990, Nihon Kyosei Shika Gakkai zasshi = The journal of Japan Orthodontic Society.

[49]  D B Burr,et al.  Errors in bone remodeling: toward a unified theory of metabolic bone disease. , 1989, The American journal of anatomy.

[50]  J. Wolff.  Das Gesetz der Transformation der Knochen , 1893 .

[51]  L. Raisz,et al.  Prostaglandins: Mechanisms of action and regulation of production in bone , 2005, Osteoporosis International.

[52]  R. Rauramaa,et al.  Regular Physical Exercise and Bone Mineral Density: A Four-Year Controlled Randomized Trial in Middle-aged Men. The DNASCO Study , 2001, Osteoporosis International.

[53]  平野 徹.  Anabolic effects of human biosynthetic parathyroid hormone fragment (1-34), LY333334, on remodeling and mechanical properties of cortical bone in rabbits , 1999 .

[54]  J. Chow,et al.  Role for parathyroid hormone in mechanical responsiveness of rat bone. , 1998, American journal of physiology. Endocrinology and metabolism.

[55]  R Huiskes,et al.  Validation of adaptive bone-remodeling simulation models. , 1997, Studies in health technology and informatics.

[56]  R. Huiskes,et al.  A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models. , 1995, Journal of biomechanics.

[57]  Hwj Rik Huiskes,et al.  Stress shielding and bone resorption in THA: clinical versus computer-simulation studies. , 1993, Acta orthopaedica Belgica.

[58]  R. Huiskes,et al.  The relationship between stress shielding and bone resorption around total hip stems and the effects of flexible materials. , 1992, Clinical orthopaedics and related research.

[59]  H. Grootenboer,et al.  Adaptive bone-remodeling theory applied to prosthetic-design analysis. , 1987, Journal of biomechanics.