Syntheses and evaluation of biodegradable multifunctional polymer networks

Abstract The biodegradable, injectable and in situ crosslinkable polymer networks based upon di(propylene fumarate)–dimethacrylate (DPFDMA) and polycaprolactone trimethacrylate (PCLTMA), were prepared and characterized. The polymer networks were initiated by photopolymerization. The initial compressive (CS) and diametral tensile strengths (DTS) of the networks materials were determined and used to evaluate the effects of PCLTMA/DPFDMA ratios on the degradation behavior. The networks exhibited initial DTS values ranging from 2.5 to 9.3 MPa and CS values ranging from 1.8 to 146.0 MPa. The increase of PCLTMA in the formulation led to an increase in viscosity and DTS. The degree of conversions and polymerization shrinkage of the resins ranged from 60% to 72% and 5.1% to 6.4%, respectively. After 6 month, PCL300TMA/DPFDMA resins at a ratio of 100/0, 75/25 and 25/75 lost 70%, 87% and 46% of their initial CS, respectively, while PCL900TMA/DPFDMA and PCL300TMA/PCL900TMA resins at 75/25 lost 100% and 83% of their initial CS, respectively.

[1]  R. Storey,et al.  Synthesis of bioabsorbable networks from methacrylate-endcapped polyesters , 1993 .

[2]  R. Seghi,et al.  PHYSICAL PROPERTY EVALUATIONS OF PERFLUOROTRIETHYLENE GLYCOL DIMETHACRYLATE AS A POTENTIAL REACTIVE DILUENT IN DENTAL COMPOSITE RESINS , 1999 .

[3]  A. Mikos,et al.  Synthesis of biodegradable poly(propylene fumarate) networks with poly(propylene fumarate)–diacrylate macromers as crosslinking agents and characterization of their degradation products , 2001 .

[4]  Robert Langer,et al.  Hydrolytically degradable amino acid-containing polymers , 1990 .

[5]  A. Peutzfeldt,et al.  Resin composites in dentistry: the monomer systems. , 1997, European journal of oral sciences.

[6]  A. Domb,et al.  Biodegradable bone cement compositions based on acrylate and epoxide terminated poly(propylene fumarate) oligomers and calcium salt compositions. , 1996, Biomaterials.

[7]  A. Mikos,et al.  In vivo degradation of a poly(propylene fumarate)/beta-tricalcium phosphate injectable composite scaffold. , 1998, Journal of biomedical materials research.

[8]  J A Burdick,et al.  Conversion and temperature profiles during the photoinitiated polymerization of thick orthopaedic biomaterials. , 2001, Biomaterials.

[9]  R. Langer,et al.  Chemical changes during in vivo degradation of poly(anhydride-imide) matrices. , 1998, Biomaterials.

[10]  K. Uhrich,et al.  Novel Polyanhydrides with Enhanced Thermal and Solubility Properties , 2000 .

[11]  A. Mikos,et al.  Injectable biodegradable polymer composites based on poly(propylene fumarate) crosslinked with poly(ethylene glycol)-dimethacrylate. , 2000, Biomaterials.

[12]  W. Johnston,et al.  Formulation of Visible Light-Curable Glass-Ionomer Cements Containing N-Vinylpyrrolidone , 1998 .

[13]  K. Uhrich,et al.  Degradable poly(anhydride ester) implants: effects of localized salicylic acid release on bone. , 2000, Biomaterials.

[14]  D. Wise,et al.  Versatility of biodegradable biopolymers: degradability and an in vivo application. , 2001, Journal of biotechnology.

[15]  R. Seghi,et al.  EFFECT OF FLUORINATED TRIETHYLENE GLYCOL DIMETHACRYLATE ON THE PROPERTIES OF UNFILLED, LIGHT-CURED DENTAL RESINS , 1999 .