Solubilization and stabilization of an investigational antineoplastic drug (NSC no. 278214) in an intravenous formulation using an emulsion vehicle

Abstract The use of parenteral fat emulsions for development of an extemporaneous preparation of an intravenous formulation of a poorly water-soluble and unstable investigational anticancer agent (NSC no. 278214) is presented. The incorporation into a commercial fat emulsion of the drug, dissolved in dimethylacetamide-cremophor solution, results in a suitable parenteral formulation in which the drug is approximately 100-fold more stable than in simple aqueous solutions.