论文信息 - A new collagen-based urothelial transplant for reconstructive surgery of the lower urinary tract

A new collagen-based urothelial transplant for reconstructive surgery of the lower urinary tract

Hypothesis / aims of study Reconstructive surgery of the lower urinary tract often requires suitable grafts. Implantation of engineered tissue equivalents might be an option for urethral and ureteral reconstruction especially in patients for whom autologous grafts are not available. Urothelial implants might require biomaterials as cell carriers (1). Matrices have to be biocompatible, induce tissue regeneration, and must be subject to rapid degradation in vivo. Aim of the study was to prove adherence, viability, and growth pattern of human urothel ial cells seeded on a new factory-made bovine collagen I-based matrix.

[1] U. Nagele,et al. In vitro investigations of tissue-engineered multilayered urothelium established from bladder washings. , 2008, European urology.

[2] U. Nagele,et al. Immunoreactivity of p63 in monolayered and in vitro stratified human urothelial cell cultures compared with native urothelial tissue. , 2008, European urology.

[3] A. Stenzl,et al. Investigations of urothelial cells seeded on commercially available small intestine submucosa. , 2006, European urology.