Silencing SATB1 influences cell invasion, migration, proliferation, and drug resistance in nasopharyngeal carcinoma.

Special AT rich sequence binding protein 1 (SATB1) play an important role in many cancers, but the role of SATB1 in nasopharyngeal carcinoma (NPC) is still not full understand. Immunofluorescence staining showed that SATB1 was mainly localized in the nuclei in CNE-2 cell. After successful down-regulation of SABT1 in NPC cell line CNE-2 by shRNA, compared to parental CNE-2 and control shRNA group, the capacity of the proliferation, migration, invasion and drug resistance of CNE-2 cell was reduced, which indicated that SATB1 may be involved in NPC development and progression. SATB1 may be a promising therapeutic target for nasopharyngeal carcinoma.

[1]  Chao Zeng,et al.  Over-expression of the special AT rich sequence binding protein 1 (SATB1) promotes the progression of nasopharyngeal carcinoma: association with EBV LMP-1 expression , 2013, Journal of Translational Medicine.

[2]  Tai-Lin Huang,et al.  Quality of life and survival outcome for patients with nasopharyngeal carcinoma receiving three-dimensional conformal radiotherapy vs. intensity-modulated radiotherapy-a longitudinal study. , 2008, International journal of radiation oncology, biology, physics.

[3]  Qing-quan Li,et al.  Overexpression and involvement of special AT‐rich sequence binding protein 1 in multidrug resistance in human breast carcinoma cells , 2010, Cancer science.

[4]  J. Russo,et al.  SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis , 2008, Nature.

[5]  D. Feng,et al.  Upregulation of SATB1 is associated with the development and progression of glioma , 2012, Journal of Translational Medicine.

[6]  J. Russo,et al.  SATB 1 reprogrammes gene expression to promote breast tumour growth and metastasis , 2008 .

[7]  D. Helfman,et al.  The metastasis associated protein S100A4: role in tumour progression and metastasis , 2005, British Journal of Cancer.

[8]  H. Niida,et al.  The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development. , 2000, Genes & development.

[9]  D. Tian,et al.  Upregulation of SATB1 promotes tumor growth and metastasis in liver cancer , 2012, Liver international : official journal of the International Association for the Study of the Liver.

[10]  M. Uhlén,et al.  Molecular correlates and prognostic significance of SATB1 expression in colorectal cancer , 2012, Diagnostic Pathology.

[11]  T. Kohwi-Shigematsu,et al.  An Atypical Homeodomain in SATB1 Promotes Specific Recognition of the Key Structural Element in a Matrix Attachment Region* , 1997, The Journal of Biological Chemistry.

[12]  K. Alitalo,et al.  Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors. , 1998, The American journal of pathology.

[13]  Y. Kohwi,et al.  A tissue-specific MAR SAR DNA-binding protein with unusual binding site recognition , 1992, Cell.

[14]  I. Mian,et al.  SATB1 Cleavage by Caspase 6 Disrupts PDZ Domain-Mediated Dimerization, Causing Detachment from Chromatin Early in T-Cell Apoptosis , 2001, Molecular and Cellular Biology.

[15]  Q. Tong,et al.  SATB1 is an independent prognostic marker for gastric cancer in a Chinese population. , 2010, Oncology reports.

[16]  K. Vermeulen,et al.  Cell cycle and apoptosis , 2003, Cell proliferation.

[17]  Yingwei Xue,et al.  Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric adenocarcinoma , 2011, Journal of surgical oncology.