HIV protease inhibitors increase TNF-α and IL-6 expression in macrophages: Involvement of the RNA-binding protein HuR

[1]  P. Hylemon,et al.  HIV protease inhibitors activate the unfolded protein response and disrupt lipid metabolism in primary hepatocytes. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[2]  K. Murthy,et al.  Lentiviral siRNA silencing of sphingosine-1-phosphate receptors S1P1 and S1P2 in smooth muscle. , 2006, Biochemical and biophysical research communications.

[3]  P. Hylemon,et al.  Cellular mechanisms of lipodystrophy induction by HIV protease inhibitors , 2006 .

[4]  P. Hylemon,et al.  HIV Protease Inhibitors Activate the Unfolded Protein Response in Macrophages: Implication for Atherosclerosis and Cardiovascular Disease , 2005, Molecular Pharmacology.

[5]  David A. Brenner,et al.  Free Cholesterol-loaded Macrophages Are an Abundant Source of Tumor Necrosis Factor-α and Interleukin-6 , 2005, Journal of Biological Chemistry.

[6]  Madhu N. Rao,et al.  The effects of HIV protease inhibitors on carbohydrate and lipid metabolism , 2005, Current HIV/AIDS reports.

[7]  A. Rudich,et al.  Cellular mechanisms of insulin resistance, lipodystrophy and atherosclerosis induced by HIV protease inhibitors. , 2005, Acta physiologica Scandinavica.

[8]  Madhu N. Rao,et al.  The effects of HIV protease inhibitors on carbohydrate and lipid metabolism , 2004, Current infectious disease reports.

[9]  M. Gorospe,et al.  Prostaglandin A2-mediated Stabilization of p21 mRNA through an ERK-dependent Pathway Requiring the RNA-binding Protein HuR* , 2004, Journal of Biological Chemistry.

[10]  M. Gorospe,et al.  AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR. , 2004, The Journal of biological chemistry.

[11]  L. Nagy.  Stabilization of tumor necrosis factor-alpha mRNA in macrophages in response to chronic ethanol exposure. , 2004, Alcohol.

[12]  J. Gatell,et al.  Risk of metabolic abnormalities in patients infected with HIV receiving antiretroviral therapy that contains lopinavir-ritonavir. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[13]  Shishinn Sun,et al.  Endoplasmic reticulum stress as a correlate of cytotoxicity in human tumor cells exposed to diindolylmethane in vitro , 2004, Cell stress & chaperones.

[14]  P. Hylemon,et al.  Indinavir alters sterol and fatty acid homeostatic mechanisms in primary rat hepatocytes by increasing levels of activated sterol regulatory element-binding proteins and decreasing cholesterol 7alpha-hydroxylase mRNA levels. , 2004, Biochemical pharmacology.

[15]  F. Ohsuzu.  The roles of cytokines, inflammation and immunity in vascular diseases. , 2004, Journal of atherosclerosis and thrombosis.

[16]  Rodolphe Thiébaut,et al.  Combination antiretroviral therapy and the risk of myocardial infarction , 2003 .

[17]  M. Gorospe,et al.  Regulation of Eotaxin Gene Expression by TNF-α and IL-4 Through mRNA Stabilization: Involvement of the RNA-Binding Protein HuR 1 , 2003, The Journal of Immunology.

[18]  M. Hatzoglou,et al.  Chronic Ethanol Exposure Increases the Binding of HuR to the TNFα 3′-Untranslated Region in Macrophages* , 2003, Journal of Biological Chemistry.

[19]  George Kuriakose,et al.  The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages , 2003, Nature Cell Biology.

[20]  M. Gorospe,et al.  RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[21]  M. Gorospe.  HuR in the Mammalian Genotoxic Response: Post-Transcriptional Multitasking , 2003, Cell cycle.

[22]  Jianglin Fan,et al.  Inflammatory reactions in the pathogenesis of atherosclerosis. , 2003, Journal of atherosclerosis and thrombosis.

[23]  D. Hui.  Effects of HIV protease inhibitor therapy on lipid metabolism. , 2003, Progress in lipid research.

[24]  O. Kirk,et al.  Modelling the 3‐year risk of myocardial infarction among participants in the Data Collection on Adverse Events of Anti‐HIV Drugs (DAD) study , 2003, HIV medicine.

[25]  M. Gorospe,et al.  AMP-Activated Kinase Regulates Cytoplasmic HuR , 2002, Molecular and Cellular Biology.

[26]  J. Saklatvala,et al.  Regulation of tumour necrosis factor α mRNA stability by the mitogen‐activated protein kinase p38 signalling cascade , 2000, FEBS letters.

[27]  L. Nabors,et al.  HuR, a novel target of anti-Hu antibodies, is expressed in non-neural tissues , 1998, Journal of Neuroimmunology.

[28]  J. Steitz,et al.  Overexpression of HuR, a nuclear–cytoplasmic shuttling protein, increases the in vivo stability of ARE‐containing mRNAs , 1998, The EMBO journal.

[29]  C. Flexner.  HIV-protease inhibitors. , 1998, The New England journal of medicine.

[30]  D. Decamp,et al.  Peptidomimetic Inhibitors of Human Immunodeficiency Virus Protease ( HIV‐PR): Design, Enzyme Binding and Selectivity, Antiviral Efficacy, and Cell Permeability Properties. , 1995 .