论文信息 - FLT3 internal tandem duplication mutations are rare in agnogenic myeloid metaplasia.

FLT3 internal tandem duplication mutations are rare in agnogenic myeloid metaplasia.

We were interested in the recent report by Kelly et al[1][1] that FLT3 internal tandem duplication (FLT3-ITD) mutations, while sufficient to induce a chronic myeloproliferative disease in a murine bone marrow transplant (BMT) assay, were not sufficient to induce an acute myeloid leukemia (AML)

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[2] D. Rees,et al. FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high‐risk group , 2000, British journal of haematology.

[3] T. Naoe,et al. Molecular evolution of acute myeloid leukaemia in relapse: unstable N‐ras and FLT3 genes compared with p53 gene , 1999, British journal of haematology.

[4] M. Taniwaki,et al. Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia , 1997, Leukemia.

[5] D. Gilliland,et al. FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model. , 2002, Blood.