On the Right “Track” to Artificial Assemblers

The design of synthetic analogs to biological molecular machines offers a new vista for chemists. In this issue of Chem, McTernan et al. report an artificial synthesizer reminiscent of natural assemblers. This molecular machine is capable of forming sequence-defined oligomers by the Wittig reaction, a transformation not found in nature.

[1]  J. Fraser Stoddart,et al.  The Nature of the Mechanical Bond: From Molecules to Machines , 2016 .

[2]  J. W. Ward,et al.  Sequence-Specific Peptide Synthesis by an Artificial Small-Molecule Machine , 2013, Science.

[3]  E. Yashima,et al.  Helical polymers: synthesis, structures, and functions. , 2009, Chemical reviews.

[4]  N. Giuseppone,et al.  Design of Collective Motions from Synthetic Molecular Switches, Rotors, and Motors. , 2019, Chemical reviews.

[5]  Frits W. Vaandrager,et al.  Encoding information into polymers , 2018, Nature Reviews Chemistry.

[6]  B. K. Juluri,et al.  Biological and biomimetic molecular machines. , 2008, Nanomedicine.

[7]  C. Müller,et al.  Cooperativity and Dynamics Increase the Performance of NiFe Dry Reforming Catalysts. , 2017, Journal of the American Chemical Society.

[8]  J. W. Ward,et al.  Efficient assembly of threaded molecular machines for sequence-specific synthesis. , 2014, Journal of the American Chemical Society.

[9]  N. López,et al.  Dynamic charge and oxidation state of Pt/CeO2 single-atom catalysts , 2019, Nature Materials.

[10]  I. Aprahamian The Future of Molecular Machines , 2020, ACS central science.

[11]  G. Pacchioni,et al.  Increasing Oxide Reducibility: The Role of Metal/Oxide Interfaces in the Formation of Oxygen Vacancies , 2017 .

[12]  D. Leigh,et al.  A Track-Based Molecular Synthesizer that Builds a Single-Sequence Oligomer through Iterative Carbon-Carbon Bond Formation , 2020, Chem.

[13]  B. K. Juluri,et al.  Artificial Molecular Motors , 2010 .