Do Subgroups of Patients With Alzheimers Disease Exhibit Asymmetric Deficits on Memory Tests?

Several studies have reported asymmetric cognitive profiles in patients with Alzheimer's disease (AD), but these results have almost exclusively been found using non-memory cognitive instruments. The present study investigated whether AD patients who display lateralized profiles on non-memory cognitive instruments also exhibit asymmetric deficits on verbal versus spatial memory tests. Sixty-eight AD patients participated in the study: 36 with a High Verbal cognitive profile, and 32 with a High Spatial profile. The results indicated that the High Verbal AD patients performed significantly better than the High Spatial AD patients on verbal memory tests, but the two subgroups failed to differ on spatial memory tests. Implications of these findings for understanding the heterogeneous nature of cognitive profiles in AD patients are discussed.

[1]  L. Wahlund,et al.  Bilateral temporal lobe volume reduction parallels cognitive impairment in progressive aphasia. , 1997, Archives of neurology.

[2]  J. Démonet,et al.  Age related cognitive decline: a clinical entity? A longitudinal study of cerebral blood flow and memory performance. , 1997, Journal of neurology, neurosurgery, and psychiatry.

[3]  Nick C Fox,et al.  Presymptomatic hippocampal atrophy in Alzheimer's disease. A longitudinal MRI study. , 1996, Brain : a journal of neurology.

[4]  R. Doody,et al.  Hemispheric asymmetry in Alzheimer's disease is apparent in motor functioning. , 1996, Journal of clinical and experimental neuropsychology.

[5]  D. Delis,et al.  Spatial cognition in Alzheimer's disease: subtypes of global-local impairment. , 1992, Journal of clinical and experimental neuropsychology.

[6]  N Butters,et al.  Directed and divided attention in Alzheimer's disease: impairment in shifting of attention to global and local stimuli. , 1992, Journal of clinical and experimental neuropsychology.

[7]  D. Delis,et al.  Visuoconstructive performance and regional cerebral glucose metabolism in Alzheimer's disease. , 1991, Journal of clinical and experimental neuropsychology.

[8]  F. Duffy,et al.  Electrophysiologic comparisons between two groups of patients with Alzheimer's disease. , 1990, Archives of neurology.

[9]  M. LeMay,et al.  Temporal lobe atrophy in patients with Alzheimer disease: a CT study. , 1989, AJNR. American journal of neuroradiology.

[10]  B Horwitz,et al.  Longitudinal study of the early neuropsychological and cerebral metabolic changes in dementia of the Alzheimer type. , 1988, Journal of clinical and experimental neuropsychology.

[11]  A. J. Fridlund,et al.  Visuospatial dysfunction following unilateral brain damage: dissociations in hierarchical and hemispatial analysis. , 1988, Journal of clinical and experimental neuropsychology.

[12]  D. Delis,et al.  Visuospatial functioning before and after commissurotomy. Disconnection in hierarchical processing. , 1988, Archives of neurology.

[13]  E. Russell.  Renorming Russell's version of the Wechsler Memory Scale. , 1988, Journal of clinical and experimental neuropsychology.

[14]  J T Becker,et al.  Neuropsychological function in Alzheimer's disease. Pattern of impairment and rates of progression. , 1988, Archives of neurology.

[15]  D. Delis,et al.  Hemispheric specialization of memory for visual hierarchical stimuli , 1986, Neuropsychologia.

[16]  N L Foster,et al.  Towards a behavioral typology of Alzheimer's patients. , 1986, Journal of clinical and experimental neuropsychology.

[17]  C. L. Grady,et al.  Stability of metabolic and neuropsychological asymmetries in dementia of the Alzheimer type , 1986, Neurology.

[18]  E. Bigler,et al.  Neuropsychological and Computerized Axial Tomography Volume Characteristics of Empirically Derived Dementia Subgroups , 1985, The Journal of nervous and mental disease.

[19]  J. Haxby,et al.  Relations between Neuropsychological and Cerebral Metabolic Asymmetries in Early Alzheimer's Disease , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[20]  Robert P. Friedland,et al.  Alzheimer's disease: Anterior-posterior and lateral hemispheric alterations in cortical glucose utilization , 1985, Neuroscience Letters.

[21]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[22]  R. S. Williams,et al.  Alzheimer's disease presenting as slowly progressive aphasia. , 1984, Rhode Island medical journal.

[23]  M. Mesulam,et al.  The functional anatomy and hemispheric specialization for directed attention The role of the parietal lobe and its connectivity , 1983, Trends in Neurosciences.

[24]  R. Katzman.,et al.  Biopsy‐proved Alzheimer disease presenting as a right parietal lobe syndrome , 1982, Annals of neurology.

[25]  A. Fallgatter,et al.  Loss of Functional Hemispheric Asymmetry in Alzheimer's Dementia , 1997, European Psychiatry.

[26]  F Fazio,et al.  Correlations between cognitive impairment, middle cerebral artery flow velocity and cortical glucose metabolism in the early phase of Alzheimer's disease. , 1995, Dementia.

[27]  J. Hoffman,et al.  Neural correlates of dementia: regional brain metabolism (FDG-PET) and the CERAD neuropsychological battery. , 1994, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[28]  H. Lüders,et al.  Detection of changes in material-specific memory following temporal lobectomy using the Wechsler Memory Scale-Revised. , 1993, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[29]  D. Delis,et al.  Mechanisms of spatial impairment in Alzheimer's disease subgroups: Differential breakdown of directed attention to global^local stimuli. , 1993 .

[30]  M. Weiner,et al.  Experiences with depression in a dementia clinic. , 1991, The Journal of clinical psychiatry.

[31]  Robert A. Bornstein,et al.  The Wechsler Memory Scale—Revised , 1990 .

[32]  M Haupt,et al.  [Clinical diagnosis of Alzheimer's disease]. , 1988, Deutsche medizinische Wochenschrift.

[33]  W. F. Vonderhaar.  A COMPARATIVE STUDY OF PERFORMANCE SCALE IQ'S AND SUBTEST SCORES OF DEAF CHILDREN ON THE WECHSLER INTELLIGENCE SCALE FOR CHILDREN AND THE WECHSLER INTELLIGENCE SCALE FOR CHILDREN-REVISED , 1977 .

[34]  A. Nappi,et al.  Alzheimer ' s Disease : Cell-Specific Pathology Isolates the Hippocampal Formation , 2022 .