Imaging and neurobiological changes in late-life depression.

Depression was previously thought of as a ‘functional’ illness, without demonstrable pathology, but the advent of sophisticated neuroimaging techniques has changed this perspective. This article reviews the latest structural and functional brain imaging studies, describing the neurobiological changes which underlie this common condition.

[1]  J. Park,et al.  The influence of subcortical ischemic lesions on cognitive function and quality of life in late life depression. , 2012, Journal of affective disorders.

[2]  C. Jack,et al.  Depressive Symptoms in Mild Cognitive Impairment Predict Greater Atrophy in Alzheimer's Disease-Related Regions , 2012, Biological Psychiatry.

[3]  B. Ravnkilde,et al.  Hippocampal volume and depression: a meta-analysis of MRI studies. , 2004, The American journal of psychiatry.

[4]  Kenneth S Kendler,et al.  Major depression and coronary artery disease in the Swedish twin registry: phenotypic, genetic, and environmental sources of comorbidity. , 2009, Archives of general psychiatry.

[5]  Klaus P. Ebmeier,et al.  Does the Framingham Stroke Risk Profile predict white-matter changes in late-life depression? , 2011, International Psychogeriatrics.

[6]  H. Möller,et al.  Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression , 2008, Molecular Psychiatry.

[7]  A. Burns,et al.  Cerebrovascular Disease Cerebrovascular Damage in Late-Life Depression Is Associated With Structural and Functional Abnormalities of Subcutaneous Small Arteries , 2010 .

[8]  Klaus P. Ebmeier,et al.  The cognitive neuropsychology of depression in the elderly , 2007, Psychological Medicine.

[9]  A. Korczyn,et al.  Depression and dementia , 2009, Journal of the Neurological Sciences.

[10]  D. Mohr,et al.  Depression and cortisol responses to psychological stress: A meta-analysis , 2005, Psychoneuroendocrinology.

[11]  G. Evans,et al.  The environment of poverty: multiple stressor exposure, psychophysiological stress, and socioemotional adjustment. , 2002, Child development.

[12]  I. Hickie,et al.  Age and depression. , 1991, Journal of affective disorders.

[13]  C. Jonker,et al.  Risk factors for depression in later life; results of a prospective community based study (AMSTEL). , 2000, Journal of affective disorders.

[14]  B. McEwen,et al.  Effects of stress throughout the lifespan on the brain, behaviour and cognition , 2009, Nature Reviews Neuroscience.

[15]  P. Scheltens,et al.  Depressive symptoms predict cognitive decline and dementia in older people independently of cerebral white matter changes: the LADIS study , 2013, Journal of Neurology, Neurosurgery & Psychiatry.

[16]  Klaus P. Ebmeier,et al.  White matter hyperintensities in late life depression: a systematic review , 2007, Journal of Neurology, Neurosurgery, and Psychiatry.

[17]  G. MacQueen,et al.  A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. , 2009, Journal of psychiatry & neuroscience : JPN.

[18]  W. M. van der Flier,et al.  Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study , 2012, British Journal of Psychiatry.

[19]  Alexander Gammerman,et al.  Machine learning classification with confidence: Application of transductive conformal predictors to MRI-based diagnostic and prognostic markers in depression , 2011, NeuroImage.

[20]  Arthur W. Toga,et al.  Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment , 2011, NeuroImage.

[21]  W. Drevets,et al.  Discovering Endophenotypes for Major Depression , 2004, Neuropsychopharmacology.

[22]  Klaus P. Ebmeier,et al.  Exploring the pattern and neural correlates of neuropsychological impairment in late-life depression , 2011, Psychological Medicine.

[23]  Robert Barber,et al.  Hippocampal volume change in depression: Late- and early-onset illness compared , 2004, British Journal of Psychiatry.

[24]  C. Hammen,et al.  Hippocampal Changes Associated with Early-Life Adversity and Vulnerability to Depression , 2010, Biological Psychiatry.

[25]  A. Farmer,et al.  White matter abnormalities and illness severity in major depressive disorder , 2012, British Journal of Psychiatry.

[26]  Martin Keller,et al.  The epidemiology of major depressive episodes: results from the International Consortium of Psychiatric Epidemiology (ICPE) surveys , 2003, International journal of methods in psychiatric research.

[27]  Robert Barber,et al.  Ischemic basis for deep white matter hyperintensities in major depression: a neuropathological study. , 2002, Archives of general psychiatry.

[28]  Klaus P. Ebmeier,et al.  Cortical grey matter reductions associated with treatment-resistant chronic unipolar depression , 1998, British Journal of Psychiatry.

[29]  J. John Mann,et al.  Antidepressants increase neural progenitor cells in the human hippocampus , 2009, Neuropsychopharmacology.

[30]  R. Hen,et al.  (Radio)active Neurogenesis in the Human Hippocampus , 2013, Cell.

[31]  Klaus P. Ebmeier,et al.  Magnetic resonance imaging studies in unipolar depression: Systematic review and meta-regression analyses , 2012, European Neuropsychopharmacology.

[32]  Klaus P. Ebmeier,et al.  Magnetic resonance imaging in late-life depression: vascular and glucocorticoid cascade hypotheses , 2012, British Journal of Psychiatry.

[33]  Nicholas D. Walsh,et al.  Subregional Hippocampal Deformations in Major Depressive Disorder , 2022 .

[34]  Peter McGuffin,et al.  Hippocampal atrophy in first episode depression: a meta-analysis of magnetic resonance imaging studies. , 2011, Journal of affective disorders.

[35]  Klaus P. Ebmeier,et al.  Magnetic resonance imaging in late-life depression: multimodal examination of network disruption. , 2012, Archives of general psychiatry.

[36]  W. Taylor,et al.  The vascular depression hypothesis: mechanisms linking vascular disease with depression , 2013, Molecular Psychiatry.

[37]  Gerty J. L. M. Lensvelt-Mulders,et al.  Brain volume abnormalities in major depressive disorder: A meta‐analysis of magnetic resonance imaging studies , 2009, Human brain mapping.

[38]  Philip Scheltens,et al.  Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study , 2006, International journal of geriatric psychiatry.

[39]  S. Yusuf,et al.  Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study , 2010, The Lancet.

[40]  R. Duman,et al.  Regulation of adult neurogenesis by psychotropic drugs and stress. , 2001, The Journal of pharmacology and experimental therapeutics.

[41]  Klaus P. Ebmeier,et al.  The role of the cingulate gyrus in depression: From functional anatomy to neurochemistry , 1996, Biological Psychiatry.

[42]  Andrea Mechelli,et al.  Voxelwise meta-analysis of gray matter reduction in major depressive disorder , 2012, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[43]  Clare E. Mackay,et al.  A Systematic Review of Diffusion Tensor Imaging Studies in Affective Disorders , 2009, Biological Psychiatry.

[44]  Filippo Caraci,et al.  Depression and Alzheimer's disease: neurobiological links and common pharmacological targets. , 2010, European journal of pharmacology.

[45]  H N Wagner,et al.  Paralimbic hypoperfusion in unipolar depression. , 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[46]  Eric Vermetten,et al.  Childhood trauma associated with smaller hippocampal volume in women with major depression. , 2002, The American journal of psychiatry.

[47]  Michael Marriott,et al.  Lower hippocampal volume in patients suffering from depression: a meta-analysis. , 2004, The American journal of psychiatry.

[48]  G. Busatto,et al.  Vascular diseases and old age mental disorders: an update of neuroimaging findings , 2010, Current opinion in psychiatry.

[49]  R. Sapolsky,et al.  Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. , 2000, Archives of general psychiatry.

[50]  G. MacQueen,et al.  The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research? , 2011, Molecular Psychiatry.

[51]  C. Reynolds,et al.  Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies , 2013, British Journal of Psychiatry.

[52]  Klaus P. Ebmeier,et al.  CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. , 2013, Journal of affective disorders.

[53]  Alan J. Thomas,et al.  Relationship between cognition, magnetic resonance white matter hyperintensities, and cardiovascular autonomic changes in late-life depression. , 2012, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[54]  Olga V. Demler,et al.  The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). , 2003, JAMA.

[55]  Cheuk Y. Tang,et al.  Persistent Depressive Symptoms after Acute Coronary Syndrome Are Associated with Compromised White Matter Integrity in the Anterior Cingulate: A Pilot Study , 2010, Psychotherapy and Psychosomatics.

[56]  L. Squire.  Memory systems of the brain: A brief history and current perspective , 2004, Neurobiology of Learning and Memory.

[57]  I. Goodyer,et al.  Disturbances in Morning Cortisol Secretion in Association with Maternal Postnatal Depression Predict Subsequent Depressive Symptomatology in Adolescents , 2007, Biological Psychiatry.

[58]  Anil Gholkar,et al.  A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects. , 2004, The American journal of psychiatry.

[59]  S. Lui,et al.  Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD. , 2013, Journal of psychiatry & neuroscience : JPN.

[60]  David Loewenstein,et al.  Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. , 2006, Archives of general psychiatry.

[61]  G. Alexopoulos,et al.  'Vascular depression' hypothesis. , 1997, Archives of general psychiatry.

[62]  Klaus P. Ebmeier,et al.  Vascular Risk Factors and Depression in Later Life: A Systematic Review and Meta-Analysis , 2013, Biological Psychiatry.

[63]  P. Wolf,et al.  Depressive symptoms and risk of dementia , 2010, Neurology.

[64]  Eva Meisenzahl,et al.  Structural MRI correlates for vulnerability and resilience to major depressive disorder. , 2011, Journal of psychiatry & neuroscience : JPN.