Plasma lipoproteins and muscle adenosinetriphosphate in rabbits after local irradiation.

It was reported from this laboratory that 8 days after one hind limb of a rabbit had been exposed to X-radiation a pronounced hypercholesterolemia and hyperlipoproteinemia were observed (1). In preliminary studies it was also noted that the irradiated muscles (tibialis anticus) of these animals at 8 days postexposure showed markedly reduced concentrations of adenosinetriphosphate (ATP) (2). The present report extends the investigation to include changes in plasma lipoprotein and muscle ATP at 24 hours after local X-ray exposures and at 24 hours and 4 days after local exposures to varying rates of --radiation from a 1200-c Co6o source.