The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production.

[1]  C. Loddenkemper,et al.  Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection. , 2010, Immunity.

[2]  T. Tedder,et al.  Regulatory B Cells (B10 Cells) and Regulatory T Cells Have Independent Roles in Controlling Experimental Autoimmune Encephalomyelitis Initiation and Late-Phase Immunopathogenesis , 2010, The Journal of Immunology.

[3]  Mark S. Sundrud,et al.  Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis , 2010, Proceedings of the National Academy of Sciences.

[4]  M. Greenblatt,et al.  Calcineurin regulates innate antifungal immunity in neutrophils , 2010, The Journal of experimental medicine.

[5]  T. Randall,et al.  Effector and regulatory B cells: modulators of CD4+ T cell immunity , 2010, Nature Reviews Immunology.

[6]  Margarida Saraiva,et al.  The regulation of IL-10 production by immune cells , 2010, Nature Reviews Immunology.

[7]  U. Stervbo,et al.  Suppressive functions of activated B cells in autoimmune diseases reveal the dual roles of Toll‐like receptors in immunity , 2010, Immunological reviews.

[8]  Y. Baba,et al.  Physiological function and molecular basis of STIM1‐mediated calcium entry in immune cells , 2009, Immunological reviews.

[9]  T. Tsubata,et al.  The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals1 , 2009, The Journal of Immunology.

[10]  F. Rieux-Laucat,et al.  STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity. , 2009, The New England journal of medicine.

[11]  B. Nieswandt,et al.  STIM1 is essential for Fcgamma receptor activation and autoimmune inflammation. , 2009, Blood.

[12]  M. Fujimoto,et al.  Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. , 2008, The Journal of clinical investigation.

[13]  T. Renné,et al.  The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction , 2008, The Journal of experimental medicine.

[14]  M. Fujimoto,et al.  A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. , 2008, Immunity.

[15]  U. Steinhoff,et al.  TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity1 , 2008, The Journal of Immunology.

[16]  E. Lamperti,et al.  Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance , 2008, Nature Immunology.

[17]  Onn Brandman,et al.  STIM2 Is a Feedback Regulator that Stabilizes Basal Cytosolic and Endoplasmic Reticulum Ca2+ Levels , 2007, Cell.

[18]  S. Feske Calcium signalling in lymphocyte activation and disease , 2007, Nature Reviews Immunology.

[19]  D. Rawlings,et al.  Novel Suppressive Function of Transitional 2 B Cells in Experimental Arthritis1 , 2007, The Journal of Immunology.

[20]  D. Underhill,et al.  Dectin-1 Stimulation by Candida albicans Yeast or Zymosan Triggers NFAT Activation in Macrophages and Dendritic Cells1 , 2007, The Journal of Immunology.

[21]  M. Iino,et al.  Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum , 2006, Proceedings of the National Academy of Sciences.

[22]  M. Reth,et al.  Testing gene function early in the B cell lineage in mb1-cre mice , 2006, Proceedings of the National Academy of Sciences.

[23]  Bogdan Tanasa,et al.  A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function , 2006, Nature.

[24]  Ying Wang,et al.  A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 , 2005, Nature Immunology.

[25]  Tobias Meyer,et al.  STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx , 2005, Current Biology.

[26]  F. Macian,et al.  NFAT proteins: key regulators of T-cell development and function , 2005, Nature Reviews Immunology.

[27]  S. Wagner,et al.  STIM1, an essential and conserved component of store-operated Ca2+ channel function , 2005, The Journal of cell biology.

[28]  J. Putney,et al.  Store-operated calcium channels. , 2005, Physiological reviews.

[29]  G. Bishop The multifaceted roles of TRAFs in the regulation of B-cell function , 2004, Nature Reviews Immunology.

[30]  D. Gray,et al.  Prevention of Arthritis by Interleukin 10–producing B Cells , 2003, The Journal of experimental medicine.

[31]  David Gray,et al.  B cells regulate autoimmunity by provision of IL-10 , 2002, Nature Immunology.

[32]  R. Blumberg,et al.  Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. , 2002, Immunity.

[33]  E. Lam,et al.  Cyclin D3 Compensates for Loss of Cyclin D2 in Mouse B-lymphocytes Activated via the Antigen Receptor and CD40* , 2000, The Journal of Biological Chemistry.

[34]  A. Cross,et al.  B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide , 1999, European journal of immunology.

[35]  H. Weiner,et al.  IL-10 is critical in the regulation of automimmune encephalomyelitis as demonstrated by studies of IL-10 and IL-4 deficient and transgenic mice , 1998, Journal of Neuroimmunology.

[36]  Charles A. Janeway,et al.  Experimental Autoimmune Encephalomyelitis Induction in Genetically B Cell–deficient Mice , 1996, The Journal of experimental medicine.

[37]  F. Finkelman,et al.  bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice , 1996, The Journal of experimental medicine.

[38]  V. Kuchroo,et al.  Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. , 1993, Journal of immunology.

[39]  Klaus Rajewsky,et al.  A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene , 1991, Nature.

[40]  H. Lassmann,et al.  Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. , 1988, The American journal of pathology.

[41]  Riccardo Dalla-Favera,et al.  Germinal centres: role in B-cell physiology and malignancy , 2008, Nature Reviews Immunology.

[42]  T. Hirano,et al.  Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses , 2008, Nature Immunology.

[43]  M. Ehrenstein,et al.  The 'short' history of regulatory B cells. , 2008, Trends in immunology.