Precursor B Lymphoblastic Lymphoma of the Orbit in a Child: An Unusual Presentation of a Non-Hodgkin Lymphoma

Objective: The majority of ocular adnexal lymphomas are marginal zone lymphomas, which occur rarely in children. This case report describes a 6 years old child with a precursor B lymphoblastic lymphoma presenting in the ocular adnexa. The combination of multi-agent chemotherapy with adjuvant radiotherapy seems to be necessary in order to achieve a complete remission of this subtype of lymphoma's in ocular adnexa. Design: Retrospective case study. Method: A review of the clinical, pathological, radiological findings and follow-up in a patient from the files available at our center, which were reviewed between the years 1974 and 2004.

[1]  S. Qualman,et al.  Cutaneous Lymphoblastic Lymphoma in Children: Report of Six Cases with Precursor B-cell Lineage , 2002, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

[2]  H. Yamashita,et al.  Diagnosis and treatment of orbital malignant lymphoma: a 14-year review at Yamagata University. , 2001, Japanese journal of ophthalmology.

[3]  M. Tiemann,et al.  Precursor B-cell lymphoblastic lymphoma in childhood and adolescence: clinical features, treatment, and results in trials NHL-BFM 86 and 90. , 2000, Medical and pediatric oncology.

[4]  W. Kamps,et al.  Intensive treatment of children with acute lymphoblastic leukemia according to ALL-BFM-86 without cranial radiotherapy: results of Dutch Childhood Leukemia Study Group Protocol ALL-7 (1988-1991). , 1999, Blood.

[5]  F. Söylemezoğlu,et al.  Mucosa-associated lymphoid tissue lymphoma of the lacrimal gland. , 1999, Ophthalmic plastic and reconstructive surgery.

[6]  M. Cahill,et al.  Ocular adnexal lymphoma—comparison of MALT lymphoma with other histological types , 1999, The British journal of ophthalmology.

[7]  R. Giller,et al.  Precursor B-cell lymphoblastic lymphoma presenting as an orbital mass. , 1999, Orbit.

[8]  J. Downing,et al.  Non-Hodgkin's lymphoma in childhood. , 1996, The New England journal of medicine.

[9]  N. Harris,et al.  Ocular adnexal lymphoma. A clinicopathologic study with identification of lymphomas of mucosa-associated lymphoid tissue type. , 1995, Ophthalmology.

[10]  B. Agnarsson,et al.  Peripheral T-cell lymphomas in children. , 1995, Seminars in diagnostic pathology.

[11]  W. Hiddemann,et al.  Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86. , 1994, Blood.

[12]  R. Zaizov,et al.  Childhood B-cell non-Hodgkin's lymphoma in Israel. , 1994, Leukemia & lymphoma.

[13]  E. Maor,et al.  Primary B-cell lymphoma of the eyes and brain in a 3-year-old boy. , 1994, Archives of ophthalmology.

[14]  D. Rosberger,et al.  Aggressive orbital lymphoma in AIDS. , 1994, The British journal of ophthalmology.

[15]  R. Campbell,et al.  A review of 340 orbital tumors in children during a 60-year period. , 1994, American journal of ophthalmology.

[16]  T. Liesegang.  Ocular adnexal lymphoproliferative lesions. , 1993, Mayo Clinic proceedings.

[17]  D. Meyer,et al.  Orbital lymphoma associated with acquired immunodeficiency syndrome. , 1992, Archives of ophthalmology.

[18]  H. Bartelink,et al.  Results of radiotherapy in patients with stage I orbital non-Hodgkin's lymphoma. , 1991, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[19]  D. Horsman,et al.  Large cell orbital lymphoma in a patient with acquired immune deficiency syndrome. Case report and review. , 1990, Ophthalmology.

[20]  D. Fairclough,et al.  Non-Hodgkin's lymphomas of childhood: an analysis of the histology, staging, and response to treatment of 338 cases at a single institution. , 1989, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[21]  B. Nathwani,et al.  A morphologic study of childhood lymphoma of the lymphoblastic type the pediatric oncology group experience , 1987, Cancer.

[22]  C. Berard,et al.  Non-Hodgkin's lymphoma in children. , 1983, Human pathology.

[23]  G. Valvassori,et al.  Imaging of orbital lymphoproliferative disorders. , 1999, Radiologic clinics of North America.

[24]  C. Margo,et al.  Malignant tumors of the orbit. Analysis of the Florida Cancer Registry. , 1998, Ophthalmology.

[25]  G. Cockerham,et al.  Lymphoproliferative Disorders of the Ocular Adnexa , 1997, International ophthalmology clinics.

[26]  B. Streeten,et al.  Burkitt lymphoma presenting as a conjunctival mass. , 1995, Ophthalmology.

[27]  M. Warzynski,et al.  Orbital lymphoma associated with acquired immune deficiency syndrome (AIDS). , 1994, Survey of ophthalmology.

[28]  J. Seigneurin,et al.  Non‐Hodgkin's lymphoma in four children infected with the human immunodeficiency virus. Association with Epstein‐Barr virus and treatment , 1994, Cancer.

[29]  M. Büyükpamukçu,et al.  Primary subconjunctival lymphoma: an unusual presentation of childhood non-Hodgkin's lymphoma. , 1991, Medical and pediatric oncology.

[30]  J. Zucker,et al.  High survival rate in advanced-stage B-cell lymphomas and leukemias without CNS involvement with a short intensive polychemotherapy: results from the French Pediatric Oncology Society of a randomized trial of 216 children. , 1991, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.