Structures involved at the time of temporal lobe spikes revealed by interindividual group analysis of EEG/fMRI data

Purpose:  We measured metabolic changes associated with temporal lobe (TL) spikes using combined electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). We selected 18 patients with temporal lobe epilepsy (TLE) who underwent a 2‐h simultaneous EEG–fMRI and had unilateral or bilateral independent TL spikes for interindividual group analysis, in order to identify consistent blood oxygenation level dependent (BOLD) responses to TL spikes.

[1]  Philippe Kahane,et al.  The hidden causes of surgery-resistant temporal lobe epilepsy: extratemporal or temporal plus? , 2005, Current opinion in neurology.

[2]  M. Raichle,et al.  Anatomic Localization and Quantitative Analysis of Gradient Refocused Echo-Planar fMRI Susceptibility Artifacts , 1997, NeuroImage.

[3]  Seung Bong Hong,et al.  Cerebral perfusion changes in mesial temporal lobe epilepsy: SPM analysis of ictal and interictal SPECT , 2005, NeuroImage.

[4]  Jean Gotman,et al.  Negative BOLD responses to epileptic spikes , 2006, Human brain mapping.

[5]  P. Gloor,et al.  The human dorsal hippocampal commissure. An anatomically identifiable and functional pathway. , 1993, Brain : a journal of neurology.

[6]  G L Shulman,et al.  INAUGURAL ARTICLE by a Recently Elected Academy Member:A default mode of brain function , 2001 .

[7]  Bertrand Devaux,et al.  Metabolic changes and electro-clinical patterns in mesio-temporal lobe epilepsy: a correlative study. , 2004, Brain : a journal of neurology.

[8]  J Gotman,et al.  Reliability of dipole models of epileptic spikes , 1999, Clinical Neurophysiology.

[9]  J. Gotman,et al.  Temporal and Extratemporal BOLD Responses to Temporal Lobe Interictal Spikes , 2006, Epilepsia.

[10]  W. Penfield,et al.  Incisural sclerosis and temporal lobe seizures produced by hippocampal herniation at birth. , 1953, A.M.A. archives of neurology and psychiatry.

[11]  Pablo A. Rio,et al.  Voxel-based morphometry reveals gray matter network atrophy in refractory medial temporal lobe epilepsy. , 2004, Archives of neurology.

[12]  Colin Studholme,et al.  Positive and negative network correlations in temporal lobe epilepsy. , 2004, Cerebral cortex.

[13]  Anthony B Waites,et al.  fMRI “deactivation” of the posterior cingulate during generalized spike and wave , 2003, NeuroImage.

[14]  Neda Bernasconi,et al.  MRI volumetry of the thalamus in temporal, extratemporal, and idiopathic generalized epilepsy , 2003, Neurology.

[15]  L Lemieux,et al.  Extrahippocampal temporal lobe atrophy in temporal lobe epilepsy and mesial temporal sclerosis. , 2001, Brain : a journal of neurology.

[16]  D. Collins,et al.  Automatic 3D Intersubject Registration of MR Volumetric Data in Standardized Talairach Space , 1994, Journal of computer assisted tomography.

[17]  Alan C. Evans,et al.  A General Statistical Analysis for fMRI Data , 2000, NeuroImage.

[18]  Thomas E. Nichols,et al.  Non-white noise in fMRI: Does modelling have an impact? , 2006, NeuroImage.

[19]  C D Binnie,et al.  Selective cognitive impairment during focal and generalized epileptiform EEG activity. , 1984, Brain : a journal of neurology.

[20]  Jean Gotman,et al.  EEG‐fMRI of focal epileptic spikes: Analysis with multiple haemodynamic functions and comparison with gadolinium‐enhanced MR angiograms , 2004, Human brain mapping.

[21]  J. Gotman,et al.  Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[22]  A. Kleinschmidt,et al.  Temporal lobe interictal epileptic discharges affect cerebral activity in “default mode” brain regions , 2006, Human brain mapping.

[23]  J S Ebersole,et al.  Spike voltage topography identifies two types of frontotemporal epileptic foci , 1991, Neurology.

[24]  Didier Dormont,et al.  Diffusion tensor imaging in medial temporal lobe epilepsy with hippocampal sclerosis , 2005, NeuroImage.