Systematic studies on synthesis, structural elucidation, and biological evaluation of A-ring diastereomers of 2-methyl-1α,25-dihydroxyvitamin D3 and 20-epi-2-methyl-1α,25-dihydroxyvitamin D3

[1]  K. Nakagawa,et al.  Structure-specific control of differentiation and apoptosis of human promyelocytic leukemia (HL-60) cells by A-ring diastereomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) and its 20-epimer. , 2000, Biochemical pharmacology.

[2]  K. Ozono,et al.  Novel ring A stereoisomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) and 2-methyl-20-epi-1alpha,25-dihydroxyvitamin D(3): transactivation of target genes and modulation of differentiation in human promyelocytic leukemia (HL-60) cells. , 2000, Biochemical pharmacology.

[3]  H. DeLuca,et al.  New 1alpha,25-dihydroxy-19-norvitamin D3 compounds of high biological activity: synthesis and biological evaluation of 2-hydroxymethyl, 2-methyl, and 2-methylene analogues. , 1998, Journal of medicinal chemistry.

[4]  K. Konno,et al.  Synthesis and biological activity of 2-methyl-20-epi analogues of 1α,25-dihydroxyvitamin D3 , 1998 .

[5]  S. Maki,et al.  A novel and practical route to A-ring enyne synthon for 1α,25-dihydroxyvitamin D3 analogs: Synthesis of A-ring diastereomers of 1α,25-dihydroxyvitamin D3 and 2-methyl-1,25-dihydroxyvitamin D3 , 1998 .

[6]  D. Feldman,et al.  Chemistry and design: structural biology of vitamin D action , 1997 .

[7]  H. DeLuca,et al.  The Vitamin D Endocrine System and Its Therapeutic Potential , 1996 .

[8]  A. Kutner,et al.  Crystal and molecular structure of 1,25‐dihydroxycholecalciferol , 1996 .

[9]  R. Bouillon,et al.  Structure-function relationships in the vitamin D endocrine system. , 1995, Endocrine reviews.

[10]  S. Rychnovsky,et al.  Analysis of two carbon-13 NMR correlations for determining the stereochemistry of 1,3-diol acetonides , 1993 .

[11]  A. Lera,et al.  Studies of vitamin D (calciferol) and its analogs. 45. Studies on the A-ring diastereomers of 1.alpha.,25-dihydroxyvitamin D3 , 1993 .

[12]  B. Trost,et al.  New strategies for the synthesis of vitamin D metabolites via palladium-catalyzed reactions , 1992 .

[13]  T. D. Nelson,et al.  New vitamin D3 derivatives with unexpected antiproliferative activity: 1-(hydroxymethyl)-25-hydroxyvitamin D3 homologs. , 1992, Journal of medicinal chemistry.

[14]  T. Kusumi,et al.  High-field FT NMR application of Mosher's method. The absolute configurations of marine terpenoids , 1991 .

[15]  A. Norman,et al.  Vitamin D: concerning the relationship between molecular topology and biological function. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[16]  F. Anet.  The Use of Remote Deuteration for The Determination of Coupling Constants and Conformational Equilibria in Cyclohexane Derivatives , 1962 .

[17]  H. DeLuca,et al.  1α,25-dihydroxy-19-nor-vitamin D3, a novel vitamin D-related compound with potential therapeutic activity , 1990 .