Lifetime history of alcohol consumption and K‐ras mutations in pancreatic ductal adenocarcinoma

In pancreatic ductal adenocarcinoma (PDA), evidence on the etiopathogenic role of alcohol consumption in the occurrence of K‐ras mutations is scant, and the role of alcohol in pancreatic carcinogenesis is not well established. We analyzed the relation between lifetime consumption of alcohol and mutations in codon 12 of the K‐ras oncogene in patients with PDA.

[1]  A. Carrato,et al.  Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study , 2009, Cancer Causes & Control.

[2]  F. Real,et al.  Pancreatic cancer development and progression: remodeling the model. , 2008, Gastroenterology.

[3]  M. Omary,et al.  Epidemiology of alcohol-related liver and pancreatic disease in the United States. , 2008, Archives of internal medicine.

[4]  Manal M. Hassan,et al.  Risk Factors for Pancreatic Cancer: Case-Control Study , 2007, The American Journal of Gastroenterology.

[5]  F. Stickel,et al.  “Allgemeine und systematische Pharmakologie und Toxikologie” WS 18/19 Seminarthema: Chemische Kanzerogenese , 2017 .

[6]  J. Abbruzzese,et al.  Lifestyle, Occupational, and Reproductive Factors in Relation to Pancreatic Cancer Risk , 2007, Pancreas.

[7]  N. Malats,et al.  Lifetime History of Tobacco Consumption and K-ras Mutations in Exocrine Pancreatic Cancer , 2007, Pancreas.

[8]  N. Malats,et al.  Food and nutrient intakes and K-ras mutations in exocrine pancreatic cancer , 2007, Journal of Epidemiology and Community Health.

[9]  M. Otsuki,et al.  4. Chronic pancreatitis and pancreatic cancer, lifestyle-related diseases. , 2007, Internal medicine.

[10]  H. Friess,et al.  Update on pancreatic cancer and alcohol‐associated risk , 2006, Journal of gastroenterology and hepatology.

[11]  Qing Zhang,et al.  Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients , 2006, International journal of cancer.

[12]  P. A. van den Brandt,et al.  Alcohol and the risk of colon and rectal cancer with mutations in the K-ras gene. , 2006, Alcohol.

[13]  P. Maisonneuve,et al.  Epidemiology and risk factors for pancreatic cancer. , 2006, Best practice & research. Clinical gastroenterology.

[14]  S. Hecht,et al.  Identification of an acetaldehyde adduct in human liver DNA and quantitation as N2-ethyldeoxyguanosine. , 2006, Chemical research in toxicology.

[15]  N. Malats,et al.  Exocrine pancreatic cancer: Symptoms at presentation and their relation to tumour site and stage , 2005, Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.

[16]  V. Go,et al.  Alcohol and pancreatic cancer. , 2005, Alcohol.

[17]  P. Rosenbaum The Case‐Only Odds Ratio as a Causal Parameter , 2004, Biometrics.

[18]  Xiang‐Dong Wang,et al.  Alcohol and cancer: genetic and nutritional aspects , 2004, Proceedings of the Nutrition Society.

[19]  N. Malats,et al.  Validity of the hospital discharge diagnosis in epidemiologic studies of biliopancreatic pathology , 2000, European Journal of Epidemiology.

[20]  N. Malats,et al.  Medical Conditions in Patients with Pancreatic and Biliary Diseases (Validity and Agreement Between Data from Questionnaires and Medical Records) , 1999, Digestive Diseases and Sciences.

[21]  N. Malats,et al.  Occupational exposure to dyes, metals, polycyclic aromatic hydrocarbons and other agents and K‐ras activation in human exocrine pancreatic cancer , 2003, International journal of cancer.

[22]  J. Cameron,et al.  Multicomponent Analysis of the Pancreatic Adenocarcinoma Progression Model Using a Pancreatic Intraepithelial Neoplasia Tissue Microarray , 2003, Modern Pathology.

[23]  M. Salaspuro Alcohol consumption and cancer of the gastrointestinal tract. , 2003, Best practice & research. Clinical gastroenterology.

[24]  M. Barbacid,et al.  RAS oncogenes: the first 30 years , 2003, Nature Reviews Cancer.

[25]  D. Purdie Statistical Methods in Medical Research, 4th edn , 2003 .

[26]  R. DePinho,et al.  Pancreatic cancer biology and genetics , 2002, Nature Reviews Cancer.

[27]  H. Adami,et al.  Alcohol abuse and the risk of pancreatic cancer , 2002, Gut.

[28]  N. Malats,et al.  Family history of cancer and germline BRCA2 mutations in sporadic exocrine pancreatic cancer , 2002, Gut.

[29]  T. Sarkola,et al.  Ethanol, acetaldehyde, acetate, and lactate levels after alcohol intake in white men and women: effect of 4-methylpyrazole. , 2002, Alcoholism, clinical and experimental research.

[30]  N. Malats,et al.  Generalizing molecular results arising from incomplete biological samples: expected bias and unexpected findings. , 2002, Annals of epidemiology.

[31]  N. Malats,et al.  Occupational exposure to organic solvents and K-ras mutations in exocrine pancreatic cancer. , 2002, Carcinogenesis.

[32]  F. Bosch,et al.  Increased rectal cell proliferation following alcohol abuse , 2001, Gut.

[33]  W. Willett,et al.  Coffee and alcohol consumption and the risk of pancreatic cancer in two prospective United States cohorts. , 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[34]  X. Estivill,et al.  Cystic fibrosis transmembrane regulator ( CFTR ) (cid:196) F508 mutation and 5T allele in patients with chronic pancreatitis and exocrine pancreatic cancer , 2000 .

[35]  M. Leppert,et al.  Associations between dietary intake and Ki-ras mutations in colon tumors: a population-based study. , 2000, Cancer research.

[36]  N. Malats,et al.  Coffee, pancreatic cancer, and K-rasmutations: updating the research agenda , 2000, Journal of epidemiology and community health.

[37]  N. Malats,et al.  Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer , 1999, The Lancet.

[38]  N. Malats,et al.  Association between coffee drinking and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group. , 1999, Journal of epidemiology and community health.

[39]  N. Malats,et al.  Human cancer, carcinogenic exposures and mutation spectra. , 1999, Mutation research.

[40]  P. Tolbert,et al.  Patterns of genetic alterations in pancreatic cancer: A pooled analysis , 1999, Environmental and molecular mutagenesis.

[41]  N. Malats,et al.  Learning from case reports: diagnostic issues in an epidemiologic study of pancreatic cancer. , 1998, Journal of clinical epidemiology.

[42]  N. Malats,et al.  Occurrence, trends and environment etiology of pancreatic cancer. , 1998, Scandinavian journal of work, environment & health.

[43]  N. Malats,et al.  Ki‐ras mutations in exocrine pancreatic cancer: Association with clinico‐pathological characteristics and with tobacco and alcohol consumption , 1997, International journal of cancer.

[44]  E. Fernández,et al.  Concordancia entre la información facilitada por el paciente y un familiar sobre antecedentes, patológicos, consumo de tabaco, de alcohol, de café, y dieta en el cáncer de páncreas exocrino y del sistema biliar extrahepático , 1995 .

[45]  N. Malats,et al.  Diagnostic certainty and potential for misclassification in exocrine pancreatic cancer. PANKRAS I Project Investigations. , 1994, Journal of clinical epidemiology.

[46]  R. Russell,et al.  Enhancement of ethanol induced rectal mucosal hyper regeneration with age in F344 rats. , 1994, Gut.

[47]  C B Begg,et al.  Statistical analysis of molecular epidemiology studies employing case-series. , 1994, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[48]  Jack A. Taylor,et al.  Non-hierarchical logistic models and case-only designs for assessing susceptibility in population-based case-control studies. , 1994, Statistics in medicine.

[49]  M. Berger,et al.  Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat. , 1990, Gastroenterology.

[50]  Martin Bland,et al.  An Introduction to Medical Statistics , 1987 .

[51]  Sander Greenland,et al.  Modern Epidemiology 3rd edition , 1986 .