Schizophrenia and the brain: a prospective clinico-neuropathological study

Synopsis The neuropathological results from a prospective, systematically assessed, series of 56 schizophrenic patients and 56 age- and sex-matched normal controls have been presented. When compared with the normal controls, the brains of the schizophrenic subjects showed a significant reduction in brain weight and brain length with a concomitant increase in ventricular size. (All findings relate to measurements made after formalin fixation). In addition, the brains of the schizophrenic patients contained significantly more non-specific focal pathology and fibrillary gliosis than the controls. After exclusion of cases with moderate and severe Alzheimer-type change, cerebro-vascular disease and all forms of focal pathology, the structural brain changes (i.e. decrease in brain weight and brain length) continued to distinguish the schizophrenia group from the controls. Furthermore, an analysis of the clinical data showed that the structural brain changes were correlated in the schizophrenic patients with a measurement of pre-morbid function. The findings and their possible aetiological implications have been discussed.

[1]  T. Crow,et al.  Schizophrenia as an anomaly of development of cerebral asymmetry. A postmortem study and a proposal concerning the genetic basis of the disease. , 1989, Archives of general psychiatry.

[2]  P. McGuffin,et al.  Schizophrenia: The Major Issues , 1988 .

[3]  D. Weinberger.  PREMORBID NEUROPATHOLOGY IN SCHIZOPHRENIA , 1988, The Lancet.

[4]  D. Weinberger,et al.  Stability of CT scan findings in schizophrenia: results of an 8 year follow-up study. , 1988, Journal of neurology, neurosurgery, and psychiatry.

[5]  M. Casanova,et al.  Gliosis in schizophrenia , 1987, Biological Psychiatry.

[6]  C. Bruton,et al.  The neuropathology of temporal lobe epilepsy , 1988 .

[7]  B. Pakkenberg,et al.  Post-mortem Study of Chronic Schizophrenic Brains , 1987, British Journal of Psychiatry.

[8]  Eve C. Johnstone,et al.  Is there gliosis in schizophrenia? Investigation of the temporal lobe , 1987, Biological Psychiatry.

[9]  G. Eisenhauer,et al.  CT Scan and MRI Findings in a Child With Schizophrenia , 1987, Journal of child neurology.

[10]  T. Crow,et al.  The neuropathology of schizophrenia--a progress report. , 1987, British medical bulletin.

[11]  M. Reveley,et al.  Application of imaging techniques. , 1987, British medical bulletin.

[12]  T. Crow,et al.  Gliosis in schizophrenia: A survey , 1986, Biological Psychiatry.

[13]  C. Shapiro.  Handbook of psychiatry 5: The scientific foundations of psychiatry: Edited by M. Shepherd. Cambridge University Press, 1985. $17.50 , 1986 .

[14]  R Jagoe,et al.  Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder. , 1986, Archives of general psychiatry.

[15]  B. Bogerts,et al.  Basal Ganglia and Limbic System Pathology in Schizophrenia: A Morphometric Study of Brain Volume and Shrinkage , 1985 .

[16]  A. Reveley,et al.  TOWARDS AN AETIOLOGICAL CLASSIFICATION OF SCHIZOPHRENIA , 1985, The Lancet.

[17]  K. Jellinger.  Morphological Backgrounds of Pathochemical Studies in Major Psychoses , 1985 .

[18]  P. Riederer,et al.  Pathochemical Markers in Major Psychoses , 1985, Springer Berlin Heidelberg.

[19]  A. Scheibel,et al.  A neurohistological correlate of schizophrenia. , 1984, Biological psychiatry.

[20]  D. Weinberger.  Computed tomography (CT) findings in schizophrenia: speculation on the meaning of it all. , 1984, Journal of psychiatric research.

[21]  J. Stevens,et al.  Neuropathology of schizophrenia. , 1982, Archives of general psychiatry.

[22]  C. Frith,et al.  Spontaneous involuntary disorders of movement: their prevalence, severity, and distribution in chronic schizophrenics with and without treatment with neuroleptics. , 1982, Archives of general psychiatry.

[23]  E. Johnstone,et al.  The Disabilities of Chronic Schizophrenia—their Nature and the Factors Contributing to their Development , 1980, British Journal of Psychiatry.

[24]  D. Weinberger,et al.  Structural abnormalities in the cerebral cortex of chronic schizophrenic patients. , 1979, Archives of general psychiatry.

[25]  J A Corsellis,et al.  Evidence for a secular increase in human brain weight during the past century. , 1977, Annals of human biology.

[26]  F. Gilles,et al.  Gyral development of the human brain , 1977, Transactions of the American Neurological Association.

[27]  T. Crow,et al.  CEREBRAL VENTRICULAR SIZE AND COGNITIVE IMPAIRMENT IN CHRONIC SCHIZOPHRENIA , 1976, The Lancet.

[28]  John K. Wing,et al.  Measurement and Classification of Psychiatric Symptoms: An Instruction Manual for the PSE and Catego Program , 1974 .

[29]  E. Torrey,et al.  Slow and latent viruses in schizophrenia. , 1973, Lancet.

[30]  F Plum,et al.  Prospects for research on schizophrenia. 3. Neurophysiology. Neuropathological findings. , 1972, Neurosciences Research Program bulletin.

[31]  J. Feighner,et al.  Diagnostic criteria for use in psychiatric research. , 1972, Archives of general psychiatry.

[32]  L. Boshes.  Current Problems in Neuropsychiatry: Schizophrenia, Epilepsy, the Temporal Lobe , 1971 .

[33]  P. Tobias.  Brain-size, grey matter and race--fact or fiction? , 1970, American journal of physical anthropology.

[34]  J. Minckler.  Pathology of the nervous system , 1968 .

[35]  L. Crome,et al.  Pathology of Mental Retardation , 1973 .

[36]  P. Storey.  Lumbar Air Encephalography in Chronic Schizophrenia: A Controlled Experiment , 1966, British Journal of Psychiatry.

[37]  E. Frandsen.  TOXIC AMBLYOPIA DURING ANTIDEPRESSANT TREATMENT WITH PHENIPRAZINE (CATRAN®) , 1962, Acta psychiatrica Scandinavica.

[38]  Haug Jo.  Pneumoencephalographic studies in mental disease. , 1962 .

[39]  L. Crome.  The Brain and Mental Retardation* , 1960, British medical journal.

[40]  D. Richter.  Schizophrenia : somatic aspects , 1957 .

[41]  L. Wilkins.  The Biology of Mental Health and Disease , 1953 .

[42]  G. Bonin.  Essay on the cerebral cortex , 1950 .

[43]  G. Bonin.  On the cerebral cortex. , 1950 .

[44]  N. W. Winkelman,et al.  OBSERVATIONS ON THE HISTOPATHOLOGY OF SCHIZOPHRENIA , 1949 .

[45]  G. Peters.  Zur Frage der pathologischen Anatomie der Schizophrenie , 1938 .

[46]  Hans W. Gruhle,et al.  Grundriss der Psychiatrie , 1937 .

[47]  F. Wertham,et al.  The Brain as an organ : its postmortem study and interpretation , 1935 .

[48]  W. Spielmeyer.  THE PROBLEM OF THE ANATOMY OF SCHIZOPHRENIA , 1930 .

[49]  K. Menninger.  THE SCHIZOPHRENIC SYNDROME AS A PRODUCT OF ACUTE INFECTIOUS DISEASE , 1928 .

[50]  A. Petrie.  The Constitutional Factors in Dementia Præcox , 1924 .

[51]  Charles B. Dunlap.  DEMENTIA PRÆCOX: Some Preliminary Observations on Brains from Carefully Selected Cases, and a Consideration of Certain Sources of Error , 1924 .

[52]  E. Southard.  A STUDY OF THE DEMENTIA PRÆCOX GROUP IN THE LIGHT OF CERTAIN CASES SHOWING ANOMALIES OR SCLEROSES IN PARTICULAR BRAIN-REGIONS , 1910 .

[53]  A. Alzheimer.  Beiträge zur pathologischen Anatomie der Hirnrinde und zur anatomischen Grundlage einiger Psychosen. (Part 1 of 2) , 1897 .

[54]  J. Crichton-Browne.  ON THE WEIGHT OF THE BRAIN AND ITS COMPONENT PARTS IN THE INSANE , 1879 .