mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

[1]  Raptor Forms a Nutrient-Sensitive Complex with mTOR , 2002, Science's STKE.

[2]  L. Johnston,et al.  Control of growth and organ size in Drosophila , 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.

[3]  George Thomas,et al.  Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K , 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.

[4]  Jun Qin,et al.  ATR and ATRIP: Partners in Checkpoint Signaling , 2001, Science.

[5]  A. Jaeschke,et al.  Mammalian TOR: A Homeostatic ATP Sensor , 2001, Science.

[6]  Benno J. Rensing,et al.  Sustained Suppression of Neointimal Proliferation by Sirolimus-Eluting Stents: One-Year Angiographic and Intravascular Ultrasound Follow-Up , 2001, Circulation.

[7]  P. Majumder,et al.  Targeting of protein kinase C delta to mitochondria in the oxidative stress response. , 2001, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[8]  E. Sausville,et al.  Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[9]  T. Tuschl,et al.  Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.

[10]  A. Gingras,et al.  Regulation of translation initiation by FRAP/mTOR. , 2001, Genes & development.

[11]  M. Mcdaniel,et al.  Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells. , 2001, Diabetes.

[12]  G. Brunn,et al.  Insulin signaling and the control of PHAS-I phosphorylation. , 2001, Progress in molecular and subcellular biology.

[13]  John F. Timms,et al.  Cellular function of phosphoinositide 3-kinases: Implications for development, immunity, homeostasis, and cancer , 2001 .

[14]  M. Metcalfe,et al.  Rapamycin in transplantation: a review of the evidence. , 2001, Kidney international.

[15]  M. Hidalgo,et al.  The rapamycin-sensitive signal transduction pathway as a target for cancer therapy , 2000, Oncogene.

[16]  T. P. Neufeld,et al.  Regulation of cellular growth by the Drosophila target of rapamycin dTOR. , 2000, Genes & development.

[17]  E. Hafen,et al.  Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. , 2000, Genes & development.

[18]  Tobias Schmelzle,et al.  TOR, a Central Controller of Cell Growth , 2000, Cell.

[19]  S. Kimball,et al.  Regulation of amino acid–sensitive TOR signaling by leucine analogues in adipocytes , 2000, Journal of cellular biochemistry.

[20]  S. Schreiber,et al.  FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions* , 2000, The Journal of Biological Chemistry.

[21]  Yoshinori Watanabe,et al.  Novel WD-Repeat Protein Mip1p Facilitates Function of the Meiotic Regulator Mei2p in Fission Yeast , 2000, Molecular and Cellular Biology.

[22]  P. Tempst,et al.  Tuning of an electrospray ionization source for maximum peptide-ion transmission into a mass spectrometer. , 2000, Analytical chemistry.

[23]  Kenta Hara,et al.  Immunopurified Mammalian Target of Rapamycin Phosphorylates and Activates p70 S6 Kinase α in Vitro * , 1999, The Journal of Biological Chemistry.

[24]  E. Hafen,et al.  Drosophila S6 kinase: a regulator of cell size. , 1999, Science.

[25]  D. Templeton,et al.  Osmotic Stress Inhibits p70/85 S6 Kinase through Activation of a Protein Phosphatase* , 1999, The Journal of Biological Chemistry.

[26]  Ronald W. Davis,et al.  Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. , 1999, Science.

[27]  S. Snyder,et al.  Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling. , 1999, Science.

[28]  A. Klip,et al.  The Insulin Signaling Pathway , 1999, The Journal of Membrane Biology.

[29]  S. Carr,et al.  Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis. , 1998, Journal of chromatography. A.

[30]  Stefano Fumagalli,et al.  Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase , 1998, The EMBO journal.

[31]  J. Avruch,et al.  Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism* , 1998, The Journal of Biological Chemistry.

[32]  S. Snyder,et al.  RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[33]  Dixon,et al.  Growth and development , 1998, Current opinion in plant biology.

[34]  A. Efstratiadis Genetics of mouse growth. , 1998, The International journal of developmental biology.

[35]  S. Kimball,et al.  Amino acids stimulate phosphorylation of p70 S6k and organization of rat adipocytes into multicellular clusters. , 1998, American journal of physiology. Cell physiology.

[36]  J. Thompson,et al.  The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. , 1997, Nucleic acids research.

[37]  M. Kasuga,et al.  Regulation of eIF-4E BP1 Phosphorylation by mTOR* , 1997, The Journal of Biological Chemistry.

[38]  Christine C. Hudson,et al.  Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. , 1997, Science.

[39]  R. Durbin,et al.  Pfam: A comprehensive database of protein domain families based on seed alignments , 1997, Proteins.

[40]  M. Goalstone,et al.  Insulin signaling. , 1997, The Western journal of medicine.

[41]  R. Abraham,et al.  Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002. , 1996, The EMBO journal.

[42]  S. Schreiber,et al.  Control of p70 S6 kinase by kinase activity of FRAP in vivo , 1995, Nature.

[43]  Peer Bork,et al.  HEAT repeats in the Huntington's disease protein , 1995, Nature Genetics.

[44]  Stuart L. Schreiber,et al.  TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin , 1995, Cell.

[45]  R. Abraham,et al.  Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells (*) , 1995, The Journal of Biological Chemistry.

[46]  V. Berlin,et al.  RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[47]  Paul Tempst,et al.  RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs , 1994, Cell.

[48]  Stuart L. Schreiber,et al.  A mammalian protein targeted by G1-arresting rapamycin–receptor complex , 1994, Nature.

[49]  E. Wolvetang,et al.  Mitochondrial respiratory chain inhibitors induce apoptosis , 1994, FEBS letters.

[50]  Charles Elkan,et al.  Fitting a Mixture Model By Expectation Maximization To Discover Motifs In Biopolymer , 1994, ISMB.

[51]  J. Kunz,et al.  Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression , 1993, Cell.

[52]  P. Bernard,et al.  The respiration of brain mitochondria and its regulation by monovalent cation transport. , 1979, Biochimica et biophysica acta.

[53]  R. Weiss Regulation of Growth , 1965, Nature.