mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
暂无分享,去创建一个
D. Sabatini | H. Erdjument-Bromage | P. Tempst | Siraj M. Ali | Do-Hyung Kim | D. Sarbassov | J. E. King | R. Latek
[1] Raptor Forms a Nutrient-Sensitive Complex with mTOR , 2002, Science's STKE.
[2] L. Johnston,et al. Control of growth and organ size in Drosophila , 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.
[3] George Thomas,et al. Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K , 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.
[4] Jun Qin,et al. ATR and ATRIP: Partners in Checkpoint Signaling , 2001, Science.
[5] A. Jaeschke,et al. Mammalian TOR: A Homeostatic ATP Sensor , 2001, Science.
[6] Benno J. Rensing,et al. Sustained Suppression of Neointimal Proliferation by Sirolimus-Eluting Stents: One-Year Angiographic and Intravascular Ultrasound Follow-Up , 2001, Circulation.
[7] P. Majumder,et al. Targeting of protein kinase C delta to mitochondria in the oxidative stress response. , 2001, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[8] E. Sausville,et al. Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[9] T. Tuschl,et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.
[10] A. Gingras,et al. Regulation of translation initiation by FRAP/mTOR. , 2001, Genes & development.
[11] M. Mcdaniel,et al. Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells. , 2001, Diabetes.
[12] G. Brunn,et al. Insulin signaling and the control of PHAS-I phosphorylation. , 2001, Progress in molecular and subcellular biology.
[13] John F. Timms,et al. Cellular function of phosphoinositide 3-kinases: Implications for development, immunity, homeostasis, and cancer , 2001 .
[14] M. Metcalfe,et al. Rapamycin in transplantation: a review of the evidence. , 2001, Kidney international.
[15] M. Hidalgo,et al. The rapamycin-sensitive signal transduction pathway as a target for cancer therapy , 2000, Oncogene.
[16] T. P. Neufeld,et al. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. , 2000, Genes & development.
[17] E. Hafen,et al. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. , 2000, Genes & development.
[18] Tobias Schmelzle,et al. TOR, a Central Controller of Cell Growth , 2000, Cell.
[19] S. Kimball,et al. Regulation of amino acid–sensitive TOR signaling by leucine analogues in adipocytes , 2000, Journal of cellular biochemistry.
[20] S. Schreiber,et al. FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions* , 2000, The Journal of Biological Chemistry.
[21] Yoshinori Watanabe,et al. Novel WD-Repeat Protein Mip1p Facilitates Function of the Meiotic Regulator Mei2p in Fission Yeast , 2000, Molecular and Cellular Biology.
[22] P. Tempst,et al. Tuning of an electrospray ionization source for maximum peptide-ion transmission into a mass spectrometer. , 2000, Analytical chemistry.
[23] Kenta Hara,et al. Immunopurified Mammalian Target of Rapamycin Phosphorylates and Activates p70 S6 Kinase α in Vitro * , 1999, The Journal of Biological Chemistry.
[24] E. Hafen,et al. Drosophila S6 kinase: a regulator of cell size. , 1999, Science.
[25] D. Templeton,et al. Osmotic Stress Inhibits p70/85 S6 Kinase through Activation of a Protein Phosphatase* , 1999, The Journal of Biological Chemistry.
[26] Ronald W. Davis,et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. , 1999, Science.
[27] S. Snyder,et al. Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling. , 1999, Science.
[28] A. Klip,et al. The Insulin Signaling Pathway , 1999, The Journal of Membrane Biology.
[29] S. Carr,et al. Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis. , 1998, Journal of chromatography. A.
[30] Stefano Fumagalli,et al. Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase , 1998, The EMBO journal.
[31] J. Avruch,et al. Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism* , 1998, The Journal of Biological Chemistry.
[32] S. Snyder,et al. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[33] Dixon,et al. Growth and development , 1998, Current opinion in plant biology.
[34] A. Efstratiadis. Genetics of mouse growth. , 1998, The International journal of developmental biology.
[35] S. Kimball,et al. Amino acids stimulate phosphorylation of p70 S6k and organization of rat adipocytes into multicellular clusters. , 1998, American journal of physiology. Cell physiology.
[36] J. Thompson,et al. The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. , 1997, Nucleic acids research.
[37] M. Kasuga,et al. Regulation of eIF-4E BP1 Phosphorylation by mTOR* , 1997, The Journal of Biological Chemistry.
[38] Christine C. Hudson,et al. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. , 1997, Science.
[39] R. Durbin,et al. Pfam: A comprehensive database of protein domain families based on seed alignments , 1997, Proteins.
[40] M. Goalstone,et al. Insulin signaling. , 1997, The Western journal of medicine.
[41] R. Abraham,et al. Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002. , 1996, The EMBO journal.
[42] S. Schreiber,et al. Control of p70 S6 kinase by kinase activity of FRAP in vivo , 1995, Nature.
[43] Peer Bork,et al. HEAT repeats in the Huntington's disease protein , 1995, Nature Genetics.
[44] Stuart L. Schreiber,et al. TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin , 1995, Cell.
[45] R. Abraham,et al. Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells (*) , 1995, The Journal of Biological Chemistry.
[46] V. Berlin,et al. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[47] Paul Tempst,et al. RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs , 1994, Cell.
[48] Stuart L. Schreiber,et al. A mammalian protein targeted by G1-arresting rapamycin–receptor complex , 1994, Nature.
[49] E. Wolvetang,et al. Mitochondrial respiratory chain inhibitors induce apoptosis , 1994, FEBS letters.
[50] Charles Elkan,et al. Fitting a Mixture Model By Expectation Maximization To Discover Motifs In Biopolymer , 1994, ISMB.
[51] J. Kunz,et al. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression , 1993, Cell.
[52] P. Bernard,et al. The respiration of brain mitochondria and its regulation by monovalent cation transport. , 1979, Biochimica et biophysica acta.
[53] R. Weiss. Regulation of Growth , 1965, Nature.