Silver Nanoparticles Interactions with the Immune System: Implications for Health and Disease

Our immune system constantly interacts with our internal environment, protects us from our external environment and provides the inherent knowledge to sense the difference between friend and foe with important implications in human health and disease (Pozo, 2008). For these reasons, it is important to identify functional alteration of key immune responses as the number of silver nano-enabled products grows while the current data strongly suggest that other related nanomaterials, such as polymer nanoparticles, fullerenes, dendrimers and gold nanoparticles, interact with the immune system.

[1]  Priyabrata Mukherjee,et al.  Biological properties of "naked" metal nanoparticles. , 2008, Advanced drug delivery reviews.

[2]  J. Maessen,et al.  The relationship between the antimicrobial effect of catheter coatings containing silver nanoparticles and the coagulation of contacting blood. , 2009, Biomaterials.

[3]  S. Paludan,et al.  Innate recognition of intracellular pathogens: detection and activation of the first line of defense , 2009, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[4]  S. Silver,et al.  Silver as biocides in burn and wound dressings and bacterial resistance to silver compounds , 2006, Journal of Industrial Microbiology and Biotechnology.

[5]  Seung-Heon Shin,et al.  The effects of nano-silver on the proliferation and cytokine expression by peripheral blood mononuclear cells. , 2007, International immunopharmacology.

[6]  R. Albrecht,et al.  Toxicity assessments of multisized gold and silver nanoparticles in zebrafish embryos. , 2009, Small.

[7]  M. Harboe,et al.  Innate Immune Responses to Danger Signals in Systemic Inflammatory Response Syndrome and Sepsis , 2009, Scandinavian journal of immunology.

[8]  Nakissa Sadrieh,et al.  Regulatory perspective on the importance of ADME assessment of nanoscale material containing drugs. , 2009, Advanced drug delivery reviews.

[9]  P. Tam,et al.  Further Evidence of the Anti‐inflammatory Effects of Silver Nanoparticles , 2009, ChemMedChem.

[10]  S. Akira,et al.  The role of Toll-like receptors in immune disorders , 2006, Expert opinion on biological therapy.

[11]  X. Chen,et al.  Nanosilver: a nanoproduct in medical application. , 2008, Toxicology letters.

[12]  Ruchi Yadav,et al.  Biogenic synthesis of silver nanoparticles and their synergistic effect with antibiotics: a study against gram-positive and gram-negative bacteria. , 2010, Nanomedicine : nanotechnology, biology, and medicine.

[13]  C. Walker,et al.  Toll-like receptors as potential therapeutic targets for multiple diseases , 2002, Nature Reviews Drug Discovery.

[14]  F. Lowy,et al.  Antimicrobial-resistant bacteria in the community setting , 2006, Nature Reviews Microbiology.

[15]  H. Klasen,et al.  A historical review of the use of silver in the treatment of burns. II. Renewed interest for silver. , 2000, Burns : journal of the International Society for Burn Injuries.

[16]  Andreas Zimmer,et al.  A practical note on the use of cytotoxicity assays. , 2005, International journal of pharmaceutics.

[17]  J. Luk,et al.  Silver Nanoparticles Inhibit Hepatitis B virus Replication , 2008, Antiviral therapy.

[18]  T. Krieg,et al.  Inflammation in wound repair: molecular and cellular mechanisms. , 2007, The Journal of investigative dermatology.

[19]  M. Yacamán,et al.  Interaction of silver nanoparticles with HIV-1 , 2005, Journal of nanobiotechnology.

[20]  A. Thomsen,et al.  Co‐ordinating innate and adaptive immunity to viral infection: mobility is the key , 2009, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[21]  A. Singh,et al.  Synthesis of Ag-Pt alloy nanoparticles in aqueous bovine serum albumin foam and their cytocompatibility against human gingival fibroblasts. , 2009, Colloids and surfaces. B, Biointerfaces.

[22]  Dae Hong Jeong,et al.  Antimicrobial effects of silver nanoparticles. , 2007, Nanomedicine : nanotechnology, biology, and medicine.

[23]  M. Rai,et al.  Silver nanoparticles as a new generation of antimicrobials. , 2009, Biotechnology advances.

[24]  J. Gearhart,et al.  In vitro toxicity of nanoparticles in BRL 3A rat liver cells. , 2005, Toxicology in vitro : an international journal published in association with BIBRA.

[25]  S. Hsu,et al.  Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes. , 2009, Small.

[26]  J. Yi,et al.  Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells. , 2009, Toxicology in vitro : an international journal published in association with BIBRA.

[27]  K. Paknikar,et al.  Silver nanoparticles in therapeutics: development of an antimicrobial gel formulation for topical use. , 2009, Molecular pharmaceutics.

[28]  P. Schechter,et al.  Topical nanocrystalline silver cream suppresses inflammatory cytokines and induces apoptosis of inflammatory cells in a murine model of allergic contact dermatitis , 2005, The British journal of dermatology.

[29]  H. Moutsopoulos,et al.  Wound healing: immunological aspects. , 2006, Injury.

[30]  L. E. Fernández,et al.  Innate‐immunity cytokines induced by very small size proteoliposomes, a Neisseria‐derived immunological adjuvant , 2007, Clinical and experimental immunology.

[31]  B. Gibbins,et al.  Antimicrobial surface functionalization of plastic catheters by silver nanoparticles. , 2008, The Journal of antimicrobial chemotherapy.

[32]  J. Guggenbichler,et al.  Prevention of catheter-related infections: the potential of a new nano-silver impregnated catheter. , 2004, International journal of antimicrobial agents.

[33]  M. Razzaque,et al.  Immunoinflammatory responses and fibrogenesis , 2004, Medical Electron Microscopy.

[34]  J. Alexander,et al.  History of the medical use of silver. , 2009, Surgical infections.

[35]  K. Wong,et al.  Topical Delivery of Silver Nanoparticles Promotes Wound Healing , 2007, ChemMedChem.

[36]  J. Schlager,et al.  In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[37]  Diana Boraschi,et al.  Innate defence functions of macrophages can be biased by nano-sized ceramic and metallic particles. , 2004, European cytokine network.

[38]  A. Makkouk,et al.  The potential use of toll-like receptor (TLR) agonists and antagonists as prophylactic and/or therapeutic agents , 2009, Immunopharmacology and immunotoxicology.

[39]  D. Pozo,et al.  Tiopronin monolayer-protected silver nanoparticles modulate IL-6 secretion mediated by Toll-like receptor ligands. , 2008, Nanomedicine.

[40]  M. Epple,et al.  Studies on the biocompatibility and the interaction of silver nanoparticles with human mesenchymal stem cells (hMSCs) , 2009, Langenbeck's Archives of Surgery.

[41]  M. Hande,et al.  Cytotoxicity and genotoxicity of silver nanoparticles in human cells. , 2009, ACS nano.

[42]  Cato T. Laurencin,et al.  Nanofibers and nanoparticles for orthopaedic surgery applications. , 2008, The Journal of bone and joint surgery. American volume.

[43]  Da-Guang Yu.  Formation of colloidal silver nanoparticles stabilized by Na+-poly(gamma-glutamic acid)-silver nitrate complex via chemical reduction process. , 2007, Colloids and surfaces. B, Biointerfaces.

[44]  I. Sondi,et al.  Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. , 2004, Journal of colloid and interface science.

[45]  P. Schechter,et al.  Effects of Nanocrystalline Silver (NPI 32101) in a Rat Model of Ulcerative Colitis , 2007, Digestive Diseases and Sciences.

[46]  S. Akira,et al.  Pathogen Recognition and Innate Immunity , 2006, Cell.