Dosagens séricas repetidas de enticonvulsivantes em pacientes epilépticas

To evaluate complacence in chronic epileptic women we collected weekly 144 blood samples from 38 patients for antiepileptic drugs determination. All the patients were supposed to have uncontrolled seizures using phenobarbital, phenytoin or carbamazepine mo-notherapeutically. We found that 34% of the blood levels were below the standard normal range. Blood level with great weekly variations were interpreted as inadequate intake by the patient. We conclude that repetitive antiepileptic blood levels determination may elucidate if the patient has drug-resistant seizures or if the patient is not complacent to the drug therapy.

[1]  M. Brodie,et al.  Antiepileptic Drug Monitoring at the Epilepsy Clinic: A Prospective Evaluation , 1991, Epilepsia.

[2]  S. Wallace.  Anti‐epileptic Drug Monitoring: an Overview , 1990, Developmental medicine and child neurology.

[3]  G. Mwaluko,et al.  Therapeutic drug monitoring (TDM): an aid to anti-epileptic drug (AED) therapy in Zimbabwe: a review. , 1990, East African Medical Journal.

[4]  G. Porro,et al.  Intractable epilepsies. An open trial with Clobazam. , 1989, Acta neurologica.

[5]  C. Cornaggia,et al.  Antiepileptic drug monitoring in severe epilepsies. , 1987, Acta neurologica.

[6]  D. Lisk,et al.  Drug compliance and seizure control in epileptic children. , 1985, Postgraduate medical journal.

[7]  F. Schobben,et al.  Continuous monitoring of plasma antiepileptic drug levels , 1983, Acta neurologica Scandinavica. Supplementum.

[8]  G. Peterson,et al.  Determinants of Patient Compliance with Anticonvulsant Therapy , 1982, Epilepsia.

[9]  W. Pryse-Phillips,et al.  Compliance with Drug Therapy by Epileptic Patients , 1982, Epilepsia.

[10]  J. Penry,et al.  Usefulness of blood levels of antiepileptic drugs. , 1974, Archives of neurology.

[11]  J. Meijer.  Knowledge, attitude and practice in antiepileptic drug monitoring. , 1991, Acta Neurologica Scandinavica, Supplementum.

[12]  R. Lesser,et al.  An overview of therapeutic drug monitoring principles. , 1984, Cleveland Clinic quarterly.

[13]  G. Scollo-Lavizzari.  Pharmacological principles in the long-term treatment of epilepsy. , 1981, European Neurology.

[14]  E. Perucca,et al.  Quality Control in Drug Measurement , 1980, Therapeutic drug monitoring.

[15]  A. Baruzzi,et al.  Indications of anticonvulsant plasma levels monitoring in medical and surgical treatment of epilepsy. , 1979, Journal of neurosurgical sciences.