Transformation Foci in IDH1-mutated Gliomas Show STAT3 Phosphorylation and Downregulate the Metabolic Enzyme ETNPPL, a Negative Regulator of Glioma Growth

[1]  H. Duffau.  Diffuse low-grade glioma, oncological outcome and quality of life: a surgical perspective , 2018, Current opinion in oncology.

[2]  P. Wesseling,et al.  WHO 2016 Classification of gliomas , 2018, Neuropathology and applied neurobiology.

[3]  H. Duffau,et al.  Cellular and molecular characterization of IDH1‐mutated diffuse low grade gliomas reveals tumor heterogeneity and absence of EGFR/PDGFRα activation , 2018, Glia.

[4]  Qing Luo,et al.  Targeting lipid metabolism of cancer cells: A promising therapeutic strategy for cancer. , 2017, Cancer letters.

[5]  Susan M. Chang,et al.  Diffuse Infiltrating Oligodendroglioma and Astrocytoma. , 2017, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  Cheng Huang,et al.  Secreted frizzled-related protein 2-mediated cancer events: Friend or foe? , 2017 .

[7]  Mariella G. Filbin,et al.  Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq , 2017, Science.

[8]  Mariella G. Filbin,et al.  Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma , 2016, Nature.

[9]  Aristeidis E. Boukouris,et al.  Metabolic Enzymes Moonlighting in the Nucleus: Metabolic Regulation of Gene Transcription. , 2016, Trends in biochemical sciences.

[10]  S. Petrini,et al.  Megalencephalic leukoencephalopathy with subcortical cysts protein-1 regulates epidermal growth factor receptor signaling in astrocytes. , 2016, Human molecular genetics.

[11]  Joachim L. Schultze,et al.  Web-TCGA: an online platform for integrated analysis of molecular cancer data sets , 2016, BMC Bioinformatics.

[12]  D. Nam,et al.  WNT signaling in glioblastoma and therapeutic opportunities , 2016, Laboratory Investigation.

[13]  E. Chang,et al.  Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse , 2016, Neuron.

[14]  A. Vortmeyer,et al.  Integrated genomic characterization of IDH1-mutant glioma malignant progression , 2015, Nature Genetics.

[15]  Hai Yan,et al.  Isocitrate dehydrogenase mutations in gliomas. , 2016, Neuro-oncology.

[16]  Qianshan Ding,et al.  AGXT2L1 is down-regulated in heptocellular carcinoma and associated with abnormal lipogenesis , 2015, Journal of Clinical Pathology.

[17]  Mathias Uhlén,et al.  Charting the human proteome: Understanding disease using a tissue-based atlas , 2015 .

[18]  G. von Heijne,et al.  Tissue-based map of the human proteome , 2015, Science.

[19]  Tatiana A. Tatusova,et al.  Gene: a gene-centered information resource at NCBI , 2014, Nucleic Acids Res..

[20]  H. Duffau,et al.  Microfoci of malignant progression in diffuse low-grade gliomas: towards the creation of an intermediate grade in glioma classification? , 2015, Virchows Archiv.

[21]  Hua Yu,et al.  Revisiting STAT3 signalling in cancer: new and unexpected biological functions , 2014, Nature Reviews Cancer.

[22]  T. Bathen,et al.  IDH1 R132H mutation generates a distinct phospholipid metabolite profile in glioma. , 2014, Cancer research.

[23]  J. Akers,et al.  RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas , 2014, Genome research.

[24]  G. Getz,et al.  Inferring tumour purity and stromal and immune cell admixture from expression data , 2013, Nature Communications.

[25]  A. Peracchi,et al.  Strict reaction and substrate specificity of AGXT2L1, the human O‐phosphoethanolamine phospho‐lyase , 2013, IUBMB life.

[26]  H. Duffau,et al.  Cell death and neuronal differentiation of glioblastoma stem‐like cells induced by neurogenic transcription factors , 2013, Glia.

[27]  P. Wesseling.  Classification of Gliomas , 2013 .

[28]  K. Aldape,et al.  Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma. , 2012, Neuro-oncology.

[29]  H. Duffau,et al.  1P19Q loss but not IDH1 mutations influences WHO grade II gliomas spontaneous growth , 2012, Journal of Neuro-Oncology.

[30]  B. Wang,et al.  Connexin 43 Reverses Malignant Phenotypes of Glioma Stem Cells by Modulating E‐Cadherin , 2012, Stem cells.

[31]  B. Deneen,et al.  Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord. , 2012, Developmental cell.

[32]  U. Cortes,et al.  STAT3 is essential for the maintenance of neurosphere‐initiating tumor cells in patients with glioblastomas: A potential for targeted therapy? , 2011, International journal of cancer.

[33]  N. Warrington,et al.  Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1. , 2010, Cancer research.

[34]  P. Bovolenta,et al.  The advantages and disadvantages of sfrp1 and sfrp2 expression in pathological events. , 2010, The Tohoku journal of experimental medicine.

[35]  S. Gabriel,et al.  Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. , 2010, Cancer cell.

[36]  Wei Keat Lim,et al.  The transcriptional network for mesenchymal transformation of brain tumors , 2009, Nature.

[37]  B. Cochran,et al.  STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells , 2009, Stem cells.

[38]  Subha Madhavan,et al.  Rembrandt: Helping Personalized Medicine Become a Reality through Integrative Translational Research , 2009, Molecular Cancer Research.

[39]  F. Ali-Osman,et al.  Constitutively Activated STAT3 Frequently Coexpresses with Epidermal Growth Factor Receptor in High-Grade Gliomas and Targeting STAT3 Sensitizes Them to Iressa and Alkylators , 2008, Clinical Cancer Research.

[40]  P. Black,et al.  A STAT3 Gene Expression Signature in Gliomas is Associated with a Poor Prognosis , 2007, Translational oncogenomics.

[41]  M. Tang,et al.  Cell Confluence-induced Activation of Signal Transducer and Activator of Transcription-3 (Stat3) Triggers Epithelial Dome Formation via Augmentation of Sodium Hydrogen Exchanger-3 (NHE3) Expression* , 2007, Journal of Biological Chemistry.

[42]  P. Black,et al.  A STAT 3 Gene Expression Signature in Gliomas is Associated with a Poor Prognosis , 2007 .

[43]  Jayant P. Menon,et al.  Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. , 2006, Cancer cell.

[44]  G. Kouraklis,et al.  Modulation of cystatin C expression impairs the invasive and tumorigenic potential of human glioblastoma cells , 2002, Oncogene.

[45]  Yoshifumi Watanabe,et al.  Ethanolamine is a co‐mitogenic factor for proliferation of primary hepatocytes , 2002, Journal of cellular biochemistry.

[46]  L. Venance,et al.  Gap junctions in brain glial cells and development. , 1995, Perspectives on developmental neurobiology.

[47]  T. Kano‐Sueoka,et al.  Effects of phosphoethanolamine and ethanolamine on growth of mammary carcinoma cells in culture. , 1981, Experimental cell research.