Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery.

Yulin Li,*,†,‡ Dina Maciel,† Joaõ Rodrigues,*,† Xiangyang Shi,*,†,§ and Helena Tomaś*,† †CQM-Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada 9000-390, Funchal, Portugal ‡The State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People’s Republic of China College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People’s Republic of China

[1]  R. Baron,et al.  Polysaccharide nanogel delivery of a TNF-alpha and RANKL antagonist peptide allows systemic prevention of bone loss. , 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[2]  K. Porter,et al.  YOLK PROTEIN UPTAKE IN THE OOCYTE OF THE MOSQUITO AEDES AEGYPTI. L , 1964, The Journal of cell biology.

[3]  D. Peer,et al.  Polysaccharides as building blocks for nanotherapeutics. , 2012, Chemical Society reviews.

[4]  K. Aoki,et al.  The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-α-induced bone resorption lacunae on mouse calvariae , 2011, Journal of Bone and Mineral Metabolism.

[5]  I. Sekiya,et al.  Protein-conjugated quantum dots effectively delivered into living cells by a cationic nanogel. , 2008, Journal of nanoscience and nanotechnology.

[6]  K. Akiyoshi,et al.  Thermoresponsive controlled association of protein with a dynamic nanogel of hydrophobized polysaccharide and cyclodextrin: heat shock protein-like activity of artificial molecular chaperone. , 2005, Biomacromolecules.

[7]  Jennifer L. West,et al.  Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration. , 2008, Biomaterials.

[8]  A. Maruyama,et al.  Dual crosslinked hydrogel nanoparticles by nanogel bottom-up method for sustained-release delivery. , 2012, Colloids and surfaces. B, Biointerfaces.

[9]  Xin Gao,et al.  Docetaxel loaded oleic acid-coated hydroxyapatite nanoparticles enhance the docetaxel-induced apoptosis through activation of caspase-2 in androgen independent prostate cancer cells. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[10]  K. Akiyoshi,et al.  Effects of cholesterol-bearing pullulan (CHP)-nanogels in combination with prostaglandin E1 on wound healing. , 2009, Journal of biomedical materials research. Part B, Applied biomaterials.

[11]  Krzysztof Matyjaszewski,et al.  Inverse miniemulsion ATRP: a new method for synthesis and functionalization of well-defined water-soluble/cross-linked polymeric particles. , 2006, Journal of the American Chemical Society.

[12]  Micheline Piquette-Miller,et al.  Biocompatibility of injectable chitosan-phospholipid implant systems. , 2009, Biomaterials.

[13]  Subhash Chandra Yadav,et al.  Development of peptide and protein nanotherapeutics by nanoencapsulation and nanobioconjugation , 2011, Peptides.

[14]  K. Na,et al.  Self-assembled chlorin e6 conjugated chondroitin sulfate nanodrug for photodynamic therapy. , 2011, Biomacromolecules.

[15]  Reuben T Chacko,et al.  Surface-functionalizable polymer nanogels with facile hydrophobic guest encapsulation capabilities. , 2010, Journal of the American Chemical Society.

[16]  Ching-Li Tseng,et al.  The use of biotinylated-EGF-modified gelatin nanoparticle carrier to enhance cisplatin accumulation in cancerous lungs via inhalation. , 2009, Biomaterials.

[17]  S. Jain,et al.  A PEGylated dendritic nanoparticulate carrier of fluorouracil. , 2003, International journal of pharmaceutics.

[18]  Fujian Xu,et al.  Biocleavable comb-shaped gene carriers from dextran backbones with bioreducible ATRP initiation sites. , 2012, Biomaterials.

[19]  X. Jing,et al.  Photo-cross-linked mPEG-poly(γ-cinnamyl-L-glutamate) micelles as stable drug carriers , 2012 .

[20]  Gorka Orive,et al.  Nanotherapeutic approaches for brain cancer management. , 2014, Nanomedicine : nanotechnology, biology, and medicine.

[21]  Ick Chan Kwon,et al.  Tumor-homing multifunctional nanoparticles for cancer theragnosis: Simultaneous diagnosis, drug delivery, and therapeutic monitoring. , 2010, Journal of Controlled Release.

[22]  K. Rostamizadeh,et al.  Preparation and characterization of tri-block poly(lactide)-poly(ethylene glycol)-poly(lactide) nanogels for controlled release of naltrexone. , 2011, International journal of pharmaceutics.

[23]  Wei Shao,et al.  Polymeric nanohybrids and functionalized carbon nanotubes as drug delivery carriers for cancer therapy. , 2011, Advanced drug delivery reviews.

[24]  P. Prasad,et al.  Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics , 2014, Chemical reviews.

[25]  Q. Ping,et al.  Glycyrrhizin surface-modified chitosan nanoparticles for hepatocyte-targeted delivery. , 2008, International journal of pharmaceutics.

[26]  Yong Huang,et al.  Dual-stimuli sensitive nanogels fabricated by self-association of thiolated hydroxypropyl cellulose , 2011 .

[27]  Samir Mitragotri,et al.  Role of Particle Size in Phagocytosis of Polymeric Microspheres , 2008, Pharmaceutical Research.

[28]  R. Misra,et al.  Magnetic drug-targeting carrier encapsulated with thermosensitive smart polymer: core-shell nanoparticle carrier and drug release response. , 2007, Acta biomaterialia.

[29]  P. Doran Cartilage Tissue Engineering , 2015, Methods in Molecular Biology.

[30]  Manuela Semmler-Behnke,et al.  Biodistribution of 1.4- and 18-nm gold particles in rats. , 2008, Small.

[31]  E. Furst,et al.  Growth factor mediated assembly of cell receptor-responsive hydrogels. , 2007, Journal of the American Chemical Society.

[32]  M. Urist,et al.  Bone: Formation by Autoinduction , 1965, Science.

[33]  H. Takeuchi,et al.  Nanoparticles of glycol chitosan and its thiolated derivative significantly improved the pulmonary delivery of calcitonin. , 2010, International journal of pharmaceutics.

[34]  N. Ravi,et al.  Synthesis of Polyacrylamide Nanogels by Intramolecular Disulfide Cross-linking , 2005 .

[35]  Yuquan Wei,et al.  Efficient inhibition of an intraperitoneal xenograft model of human ovarian cancer by HSulf-1 gene delivered by biodegradable cationic heparin-polyethyleneimine nanogels. , 2011, Oncology reports.

[36]  Randall W. King,et al.  A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion , 2007, Cell.

[37]  He Lian,et al.  Dual targeting folate-conjugated hyaluronic acid polymeric micelles for paclitaxel delivery. , 2011, International journal of pharmaceutics.

[38]  R. Haag,et al.  Polyglycerol nanogels: highly functional scaffolds for biomedical applications , 2010 .

[39]  Myron Spector,et al.  Modulation of mesenchymal stem cell chondrogenesis in a tunable hyaluronic acid hydrogel microenvironment. , 2012, Biomaterials.

[40]  L. Gan,et al.  Microemulsion polymerizations and reactions , 2005 .

[41]  T. Kissel,et al.  Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake? , 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[42]  Hongxuan He,et al.  Self-assembled nanoparticle drug delivery systems from galactosylated polysaccharide-doxorubicin conjugate loaded doxorubicin. , 2010, International journal of biological macromolecules.

[43]  Shigeru Deguchi,et al.  Self-aggregates of hydrophobized polysaccharides in water. Formation and characteristics of nanoparticles , 1993 .

[44]  A. Sharma,et al.  Photoregulation of drug release in azo-dextran nanogels. , 2007, International journal of pharmaceutics.

[45]  Eun Seong Lee,et al.  Electrostatic charge conversion processes in engineered tumor-identifying polypeptides for targeted chemotherapy. , 2012, Biomaterials.

[46]  Feng Liu,et al.  Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity. , 2005, Advanced drug delivery reviews.

[47]  Shyh-Dar Li,et al.  Preclinical pharmacokinetic, biodistribution, and anti-cancer efficacy studies of a docetaxel-carboxymethylcellulose nanoparticle in mouse models. , 2012, Biomaterials.

[48]  Junmin Zhu,et al.  Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering. , 2010, Biomaterials.

[49]  Chaoliang He,et al.  One-step preparation of reduction-responsive poly(ethylene glycol)-poly (amino acid)s nanogels as efficient intracellular drug delivery platforms , 2011 .

[50]  Kinam Park,et al.  Hydrotropic hyaluronic acid conjugates: Synthesis, characterization, and implications as a carrier of paclitaxel. , 2010, International journal of pharmaceutics.

[51]  H. Spaink,et al.  Cyclodextrin/dextran based drug carriers for a controlled release of hydrophobic drugs in zebrafish embryos , 2010 .

[52]  L. Domingues,et al.  Biological activity of heterologous murine interleukin-10 and preliminary studies on the use of a dextrin nanogel as a delivery system. , 2010, International journal of pharmaceutics.

[53]  D. Liang,et al.  Multi-responsive nanogels containing motifs of ortho ester, oligo(ethylene glycol) and disulfide linkage as carriers of hydrophobic anti-cancer drugs. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[54]  A. Concheiro,et al.  Cyclodextrin-based nanogels for pharmaceutical and biomedical applications. , 2012, International journal of pharmaceutics.

[55]  D. Mooney,et al.  Hydrogels for tissue engineering. , 2001, Chemical Reviews.

[56]  S. Nishijima,et al.  Preparation of stimuli-responsive protein nanogel by quantum-ray irradiation , 2007 .

[57]  Ping Wang,et al.  Glycyrrhetinic acid-modified poly(ethylene glycol)-b-poly(gamma-benzyl l-glutamate) micelles for liver targeting therapy. , 2010, Acta biomaterialia.

[58]  I-Ming Chu,et al.  Amphiphilic poly(D,L-lactic acid)/poly(ethylene glycol)/poly(D,L-lactic acid) nanogels for controlled release of hydrophobic drugs. , 2006, Macromolecular bioscience.

[59]  M. Garcia‐Fuentes,et al.  Chitosan-based drug nanocarriers: where do we stand? , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[60]  Wenjin Guo,et al.  Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine. , 2001, Bioconjugate chemistry.

[61]  T. Park,et al.  PEG-assisted DNA solubilization in organic solvents for preparing cytosol specifically degradable PEG/DNA nanogels. , 2006, Bioconjugate chemistry.

[62]  Qiang Zhang,et al.  Chitosan-g-poly(N-isopropylacrylamide) based nanogels for tumor extracellular targeting. , 2011, International journal of pharmaceutics.

[63]  S. Parveen,et al.  Enhanced antiproliferative activity of carboplatin-loaded chitosan-alginate nanoparticles in a retinoblastoma cell line. , 2010, Acta biomaterialia.

[64]  P. Caliceti,et al.  Novel folated and non-folated pullulan bioconjugates for anticancer drug delivery. , 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[65]  R. Singh,et al.  Aureobasidium pullulans, an economically important polymorphic yeast with special reference to pullulan , 2012 .

[66]  Y. Huang,et al.  Salt-assisted mechanistic analysis of chitosan/tripolyphosphate micro- and nanogel formation. , 2012, Biomacromolecules.

[67]  Zhen Gu,et al.  Redox-responsive nanocapsules for intracellular protein delivery. , 2011, Biomaterials.

[68]  Kwangmeyung Kim,et al.  Preparation and characterization of hyaluronic acid-based hydrogel nanoparticles , 2008 .

[69]  Li‐Ming Zhang,et al.  Bioactive supramolecular hydrogel with controlled dual drug release characteristics. , 2010, Biomacromolecules.

[70]  Kwangmeyung Kim,et al.  Polyethylene glycol-conjugated hyaluronic acid-ceramide self-assembled nanoparticles for targeted delivery of doxorubicin. , 2012, Biomaterials.

[71]  A. Higuchi,et al.  Biomimetic cell culture proteins as extracellular matrices for stem cell differentiation. , 2012, Chemical reviews.

[72]  A. Domb,et al.  Chitosan chemistry and pharmaceutical perspectives. , 2004, Chemical reviews.

[73]  Kwangmeyung Kim,et al.  Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel. , 2011, Biomaterials.

[74]  Takeshi Shimizu,et al.  Nanogel DDS enables sustained release of IL-12 for tumor immunotherapy. , 2008, Biochemical and biophysical research communications.

[75]  Ick Chan Kwon,et al.  Comparative study of photosensitizer loaded and conjugated glycol chitosan nanoparticles for cancer therapy. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[76]  Jinghua Hao,et al.  Chondrogenesis of synovium-derived mesenchymal stem cells in gene-transferred co-culture system. , 2010, Biomaterials.

[77]  R. Haag,et al.  Multifunctional dendritic polymers in nanomedicine: opportunities and challenges. , 2012, Chemical Society reviews.

[78]  S. Mitragotri,et al.  Adaptive micro and nanoparticles: temporal control over carrier properties to facilitate drug delivery. , 2011, Advanced drug delivery reviews.

[79]  J. Sanders,et al.  A unique device for controlled electrospinning. , 2006, Journal of biomedical materials research. Part A.

[80]  T. Notomi,et al.  Nanogel-based scaffold delivery of prostaglandin E(2) receptor-specific agonist in combination with a low dose of growth factor heals critical-size bone defects in mice. , 2011, Arthritis and rheumatism.

[81]  I. Kwon,et al.  Spatially mineralized self-assembled polymeric nanocarriers with enhanced robustness and controlled drug-releasing property. , 2010, Chemical communications.

[82]  Reuben T Chacko,et al.  Self-cross-linked polymer nanogels: a versatile nanoscopic drug delivery platform. , 2010, Journal of the American Chemical Society.

[83]  K. Akiyoshi,et al.  Heat Shock Protein-like Activity of a Nanogel Artificial Chaperone for Citrate Synthase , 2006 .

[84]  B. Griffin,et al.  Biopharmaceutical challenges associated with drugs with low aqueous solubility--the potential impact of lipid-based formulations. , 2008, Advanced drug delivery reviews.

[85]  L. Véron,et al.  Synthesis and structural characterization of chitosan nanogels. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[86]  A. Hoffman,et al.  Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[87]  Y. Bae,et al.  Self-assembled hydrogel nanoparticles from curdlan derivatives: characterization, anti-cancer drug release and interaction with a hepatoma cell line (HepG2). , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[88]  K. Akiyoshi,et al.  Cyclodextrin-responsive nanogel as an artificial chaperone for horseradish peroxidase , 2011 .

[89]  M. Frick,et al.  Coassembly of Flotillins Induces Formation of Membrane Microdomains, Membrane Curvature, and Vesicle Budding , 2007, Current Biology.

[90]  Francis C Szoka,et al.  Biological evaluation of polyester dendrimer: poly(ethylene oxide) "bow-tie" hybrids with tunable molecular weight and architecture. , 2005, Molecular pharmaceutics.

[91]  F. M. Gama,et al.  Self-assembled nanoparticles of dextrin substituted with hexadecanethiol. , 2007, Biomacromolecules.

[92]  H. Nader,et al.  Heparan sulfate proteoglycans: structure, protein interactions and cell signaling. , 2009, Anais da Academia Brasileira de Ciencias.

[93]  K. Akiyoshi,et al.  Botryoidal assembly of cholesteryl-pullulan/poly(N-isopropylacrylamide) nanogels. , 2007, Langmuir.

[94]  K. Webster,et al.  The effect of the controlled release of basic fibroblast growth factor from ionic gelatin-based hydrogels on angiogenesis in a murine critical limb ischemic model. , 2007, Biomaterials.

[95]  W. Degraff,et al.  Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs. , 1986, Cancer research.

[96]  T. E. Abraham,et al.  Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[97]  F. Veiga,et al.  Design for optimization of nanoparticles integrating biomaterials for orally dosed insulin. , 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[98]  J. Ra,et al.  Therapeutic lymphangiogenesis using stem cell and VEGF-C hydrogel. , 2011, Biomaterials.

[99]  A. Banerjee,et al.  Improvement of drug safety by the use of lipid-based nanocarriers. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[100]  T. Thundat,et al.  Degradable thermoresponsive nanogels for protein encapsulation and controlled release. , 2012, Bioconjugate chemistry.

[101]  Satyajit Mayor,et al.  Pathways of clathrin-independent endocytosis , 2007, Nature Reviews Molecular Cell Biology.

[102]  Bengt Fadeel,et al.  Toxicology of engineered nanomaterials: focus on biocompatibility, biodistribution and biodegradation. , 2011, Biochimica et biophysica acta.

[103]  Stephen H. D. Jackson,et al.  Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. , 2003, British journal of clinical pharmacology.

[104]  E. Kohli,et al.  Formulations of biodegradable Nanogel carriers with 5'-triphosphates of nucleoside analogs that display a reduced cytotoxicity and enhanced drug activity. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[105]  Zhi Yuan,et al.  Doxorubicin-loaded glycyrrhetinic acid-modified alginate nanoparticles for liver tumor chemotherapy. , 2012, Biomaterials.

[106]  Y. Huang,et al.  Monovalent salt enhances colloidal stability during the formation of chitosan/tripolyphosphate microgels. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[107]  Maria Jose Alonso,et al.  Chitosan-based nanostructures: a delivery platform for ocular therapeutics. , 2010, Advanced drug delivery reviews.

[108]  Kwangmeyung Kim,et al.  PEGylation of hyaluronic acid nanoparticles improves tumor targetability in vivo. , 2011, Biomaterials.

[109]  Matthew J Dalby,et al.  Hydrogel nanoparticles for drug delivery. , 2013, Nanomedicine.

[110]  H. McMahon,et al.  Mechanisms of endocytosis. , 2009, Annual review of biochemistry.

[111]  M. McNiven,et al.  Get off my back! Rapid receptor internalization through circular dorsal ruffles. , 2006, Cancer research.

[112]  I. Haririan,et al.  Release profile and stability evaluation of optimized chitosan/alginate nanoparticles as EGFR antisense vector , 2010, International journal of nanomedicine.

[113]  Scott H. Medina,et al.  N-acetylgalactosamine-functionalized dendrimers as hepatic cancer cell-targeted carriers. , 2011, Biomaterials.

[114]  吉田 圭二 Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation , 2002 .

[115]  Yu-Kyoung Oh,et al.  Target-specific intracellular delivery of siRNA using degradable hyaluronic acid nanogels. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[116]  Sinjan De,et al.  Polymer relationships during preparation of chitosan-alginate and poly-l-lysine-alginate nanospheres. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[117]  S Moein Moghimi,et al.  Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum interface: implications for stealth nanoparticle engineering. , 2010, ACS nano.

[118]  H. Chung,et al.  Self-assembled and nanostructured hydrogels for drug delivery and tissue engineering , 2009 .

[119]  Yucai Wang,et al.  Template-free synthesis of biodegradable nanogels with tunable sizes as potential carriers for drug delivery , 2009 .

[120]  P Couvreur,et al.  Development of a new drug carrier made from alginate. , 1993, Journal of pharmaceutical sciences.

[121]  B. Sarmento,et al.  Insulin-loaded nanoparticles are prepared by alginate ionotropic pre-gelation followed by chitosan polyelectrolyte complexation. , 2007, Journal of nanoscience and nanotechnology.

[122]  Clemens Burda,et al.  Nanoparticle mediated non-covalent drug delivery. , 2013, Advanced drug delivery reviews.

[123]  Ju-Hee Lee,et al.  The use of low molecular weight heparin-pluronic nanogels to impede liver fibrosis by inhibition the TGF-β/Smad signaling pathway. , 2011, Biomaterials.

[124]  R. Duncan,et al.  Dextrins as potential carriers for drug targeting: tailored rates of dextrin degradation by introduction of pendant groups. , 2001, International journal of pharmaceutics.

[125]  H. Simon,et al.  Alginate-coated chitosan nanogel capacity to modulate the effect of TLR ligands on blood dendritic cells. , 2013, Nanomedicine : nanotechnology, biology, and medicine.

[126]  David J Mooney,et al.  An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects. , 2011, Biomaterials.

[127]  H. Kiyono,et al.  Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines. , 2010, Nature materials.

[128]  S. Ishida,et al.  Uptake of glycyrrhizin by isolated rat hepatocytes. , 1993, Biological & pharmaceutical bulletin.

[129]  Probal Banerjee,et al.  In-situ immobilization of quantum dots in polysaccharide-based nanogels for integration of optical pH-sensing, tumor cell imaging, and drug delivery. , 2010, Biomaterials.

[130]  M. Alonso,et al.  Chitosan-alginate blended nanoparticles as carriers for the transmucosal delivery of macromolecules. , 2009, Biomacromolecules.

[131]  Thiennu H. Vu,et al.  Matrix metalloproteinases: effectors of development and normal physiology. , 2000, Genes & development.

[132]  J. Pinto,et al.  Synthesis of Biodegradable Hydrogel Nanoparticles for Bioapplications Using Inverse Miniemulsion RAFT Polymerization , 2011 .

[133]  Eun Seong Lee,et al.  Self-assembled glycol chitosan nanogels containing palmityl-acylated exendin-4 peptide as a long-acting anti-diabetic inhalation system. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[134]  M. Ratnam,et al.  Role of folate receptor genes in reproduction and related cancers. , 2006, Frontiers in bioscience : a journal and virtual library.

[135]  Katherine Bourzac,et al.  Nanotechnology: Carrying drugs , 2012, Nature.

[136]  P. Couvreur,et al.  Prodrug-based intracellular delivery of anticancer agents. , 2011, Advanced drug delivery reviews.

[137]  M. Holt,et al.  Coupling exo- and endocytosis: an essential role for PIP₂ at the synapse. , 2012, Biochimica et biophysica acta.

[138]  Honglei Guo,et al.  An injectable and glucose-sensitive nanogel for controlled insulin release , 2012 .

[139]  T. Park,et al.  Synthesis, characterization, and intracellular delivery of reducible heparin nanogels for apoptotic cell death. , 2008, Biomaterials.

[140]  P. Reitsma,et al.  Mechanisms of heparin induced anti-cancer activity in experimental cancer models. , 2007, Critical reviews in oncology/hematology.

[141]  Young Ha Kim,et al.  Efficient skin permeation of soluble proteins via flexible and functional nano-carrier. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[142]  R. Haag,et al.  Synthesis, Reductive Cleavage, and Cellular Interaction Studies of Biodegradable, Polyglycerol Nanogels , 2010 .

[143]  Masaki Noda,et al.  Osteoblastic bone formation is induced by using nanogel‐crosslinking hydrogel as novel scaffold for bone growth factor , 2009, Journal of cellular physiology.

[144]  Xiangyang Shi,et al.  pH sensitive Laponite/alginate hybrid hydrogels: swelling behaviour and release mechanism , 2011 .

[145]  L. Pérez-Álvarez,et al.  “Water dispersible pH-responsive chitosan nanogels modified with biocompatible crosslinking-agents” , 2012 .

[146]  S. Davis,et al.  Innovations in avoiding particle clearance from blood by Kupffer cells: cause for reflection. , 1994, Critical reviews in therapeutic drug carrier systems.

[147]  Sherry M. Tsai,et al.  A chondroitin sulfate small molecule that stimulates neuronal growth. , 2004, Journal of the American Chemical Society.

[148]  Y. Joung,et al.  Self-assembled nanogel of pluronic-conjugated heparin as a versatile drug nanocarrier , 2011 .

[149]  Probal Banerjee,et al.  Core-shell hybrid nanogels for integration of optical temperature-sensing, targeted tumor cell imaging, and combined chemo-photothermal treatment. , 2010, Biomaterials.

[150]  Tsuyoshi Shimoboji,et al.  Hybrid hyaluronan hydrogel encapsulating nanogel as a protein nanocarrier: new system for sustained delivery of protein with a chaperone-like function. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[151]  Chaoliang He,et al.  Intracellular microenvironment responsive PEGylated polypeptide nanogels with ionizable cores for efficient doxorubicin loading and triggered release , 2012 .

[152]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[153]  Vladimir P Torchilin,et al.  Liposome clearance in mice: the effect of a separate and combined presence of surface charge and polymer coating. , 2002, International journal of pharmaceutics.

[154]  Kevin J Edgar,et al.  Alginate derivatization: a review of chemistry, properties and applications. , 2012, Biomaterials.

[155]  Kwangmeyung Kim,et al.  Minimalism in fabrication of self-organized nanogels holding both anti-cancer drug and targeting moiety. , 2008, Colloids and surfaces. B, Biointerfaces.

[156]  Y. Joung,et al.  Targeting ligand-functionalized and redox-sensitive heparin-Pluronic nanogels for intracellular protein delivery , 2011, Biomedical materials.

[157]  Jianping Zhou,et al.  Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel. , 2012, Biomaterials.

[158]  Kai Yang,et al.  Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic Nanoparticles , 2012, Advanced materials.

[159]  R. Mehvar Dextrans for targeted and sustained delivery of therapeutic and imaging agents. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[160]  Hua Zheng,et al.  In vitro characterization, and in vivo studies of crosslinked lactosaminated carboxymethyl chitosan nanoparticles , 2011 .

[161]  K. Akiyoshi,et al.  Cycloamylose-based Biomaterial : Nanogel of Cholesterol-bearing Cationic Cycloamylose for siRNA Delivery , 2009 .

[162]  T. Hirano,et al.  Nanogel-quantum dot hybrid nanoparticles for live cell imaging. , 2005, Biochemical and biophysical research communications.

[163]  Yu Cao,et al.  Properties of xyloglucan hydrogel as the biomedical sustained-release carriers , 2012, Journal of Materials Science: Materials in Medicine.

[164]  Chaoliang He,et al.  Preparation of photo-cross-linked pH-responsive polypeptide nanogels as potential carriers for controlled drug delivery , 2011 .

[165]  Kwangmeyung Kim,et al.  Bioreducible block copolymers based on poly(ethylene glycol) and poly(γ-benzyl L-glutamate) for intracellular delivery of camptothecin. , 2011, Bioconjugate chemistry.

[166]  Wim E. Hennink,et al.  Artificial viruses: a nanotechnological approach to gene delivery , 2006, Nature Reviews Drug Discovery.

[167]  D. Mooney,et al.  Hydrogels for tissue engineering: scaffold design variables and applications. , 2003, Biomaterials.

[168]  Bin He,et al.  Polyethyleneimine/DNA polyplexes with reduction-sensitive hyaluronic acid derivatives shielding for targeted gene delivery. , 2013, Biomaterials.

[169]  K. Beningo,et al.  Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target. , 2002, Journal of cell science.

[170]  Liping Zhang,et al.  Preparation of complex nano-particles based on alginic acid/poly[(2-dimethylamino) ethyl methacrylate] and a drug vehicle for doxorubicin release controlled by ionic strength. , 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[171]  Rong-Sen Yang,et al.  Increased bone growth by local prostaglandin E2 in rats , 2004, Calcified Tissue International.

[172]  N. M. Zaki,et al.  Chitosan/TPP and Chitosan/TPP-hyaluronic Acid Nanoparticles: Systematic Optimisation of the Preparative Process and Preliminary Biological Evaluation , 2009, Pharmaceutical Research.

[173]  M. Khoshayand,et al.  Preparation and optimization of surface-treated methotrexate-loaded nanogels intended for brain delivery. , 2012, Carbohydrate polymers.

[174]  G. Trinchieri,et al.  Interleukin-12 and the regulation of innate resistance and adaptive immunity , 2003, Nature Reviews Immunology.

[175]  Kevin Burgess,et al.  Fluorescent indicators for intracellular pH. , 2010, Chemical reviews.

[176]  Xinqiao Jia,et al.  Controlling the adhesion and differentiation of mesenchymal stem cells using hyaluronic acid-based, doubly crosslinked networks. , 2011, Biomaterials.

[177]  Jing Shen,et al.  A nanogel of on-site tunable pH-response for efficient anticancer drug delivery. , 2013, Acta biomaterialia.

[178]  K. Na,et al.  Self-quenching polysaccharide-based nanogels of pullulan/folate-photosensitizer conjugates for photodynamic therapy. , 2010, Biomaterials.

[179]  M. Noda,et al.  Nanogel‐based delivery system enhances PGE2 effects on bone formation , 2007, Journal of cellular biochemistry.

[180]  S. Nair,et al.  Doxorubicin-loaded pH-responsive chitin nanogels for drug delivery to cancer cells , 2012 .

[181]  D. Braguer,et al.  Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[182]  Zachary Shriver,et al.  Roles of heparan-sulphate glycosaminoglycans in cancer , 2002, Nature Reviews Cancer.

[183]  K. Matyjaszewski,et al.  The development of microgels/nanogels for drug delivery applications , 2008 .

[184]  Murali M. Yallapu,et al.  Design and engineering of nanogels for cancer treatment. , 2011, Drug discovery today.

[185]  J. Benoit,et al.  Evaluation of pegylated lipid nanocapsules versus complement system activation and macrophage uptake. , 2006, Journal of biomedical materials research. Part A.

[186]  Robert J Fisher,et al.  Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF. , 2006, Biomaterials.

[187]  Wentao Lu,et al.  Acid-activatable prodrug nanogels for efficient intracellular doxorubicin release. , 2011, Biomacromolecules.

[188]  R. Singh,et al.  Enhanced biomass production study on probiotic Bacillus subtilis SK09 by medium optimization using response surface methodology , 2010 .

[189]  S. Harding,et al.  The effect of prolonged storage at different temperatures on the particle size distribution of tripolyphosphate (TPP)-chitosan nanoparticles , 2011 .

[190]  Yuquan Wei,et al.  Efficient inhibition of ovarian cancer by recombinant CXC chemokine ligand 10 delivered by novel biodegradable cationic heparin-polyethyleneimine nanogels. , 2012, Oncology reports.

[191]  K. Huh,et al.  Self-quenchable biofunctional nanoparticles of heparin–folate-photosensitizer conjugates for photodynamic therapy , 2011 .

[192]  Kozo Watanabe,et al.  The use of cationic nanogels to deliver proteins to myeloma cells and primary T lymphocytes that poorly express heparan sulfate. , 2011, Biomaterials.

[193]  Dong Liang,et al.  Pharmacokinetics and biodistribution of near-infrared fluorescence polymeric nanoparticles , 2009, Nanotechnology.

[194]  M. Alonso,et al.  A new drug nanocarrier consisting of polyarginine and hyaluronic acid. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[195]  S. Iseki,et al.  Cholesteryl group- and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering. , 2012, Biomaterials.

[196]  H. Grüll,et al.  Hyperthermia-triggered drug delivery from temperature-sensitive liposomes using MRI-guided high intensity focused ultrasound. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[197]  N. Zhang,et al.  Effective protection and controlled release of insulin by cationic beta-cyclodextrin polymers from alginate/chitosan nanoparticles. , 2010, International journal of pharmaceutics.

[198]  Eun Seong Lee,et al.  Poly(L-aspartic acid) nanogels for lysosome-selective antitumor drug delivery. , 2013, Colloids and surfaces. B, Biointerfaces.

[199]  Emanuel Fleige,et al.  Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications. , 2012, Advanced drug delivery reviews.

[200]  Hua Zheng,et al.  Disulfide cross-linked nanospheres from sodium alginate derivative for inflammatory bowel disease: Preparation, characterization, and in vitro drug release behavior , 2012 .

[201]  A. Kjøniksen,et al.  Stability of chitosan nanoparticles cross-linked with tripolyphosphate. , 2012, Biomacromolecules.

[202]  R. Samulski,et al.  Polymeric nanogels produced via inverse microemulsion polymerization as potential gene and antisense delivery agents. , 2002, Journal of the American Chemical Society.

[203]  K. Akiyoshi,et al.  Hydrogel nanoparticle formed by self-assembly of hydrophobized polysaccharide. Stabilization of adriamycin by complexation , 1996 .

[204]  Sanjay K. Jain,et al.  Perspectives of biodegradable natural polysaccharides for site-specific drug delivery to the colon. , 2007, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[205]  M. Rudemo,et al.  Hemocompatibility of siRNA loaded dextran nanogels. , 2011, Biomaterials.

[206]  Yan Jin,et al.  Novel glycidyl methacrylated dextran (Dex-GMA)/gelatin hydrogel scaffolds containing microspheres loaded with bone morphogenetic proteins: formulation and characteristics. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[207]  S. D. De Smedt,et al.  Interactions of siRNA loaded dextran nanogel with blood cells. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[208]  X. Wu,et al.  Nanotechnological advances for the delivery of CNS therapeutics. , 2012, Advanced drug delivery reviews.

[209]  Rui Guo,et al.  Gene delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors. , 2012, Biomaterials.

[210]  Roosmarijn E. Vandenbroucke,et al.  Biodegradable Dextran Nanogels for RNA Interference: Focusing on Endosomal Escape and Intracellular siRNA Delivery , 2009 .

[211]  Anderson,et al.  Biodegradation and biocompatibility of PLA and PLGA microspheres. , 1997, Advanced drug delivery reviews.

[212]  Kristina D. Micheva,et al.  Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques , 2009, Proceedings of the National Academy of Sciences.

[213]  Daocheng Wu,et al.  Preparation of rhodamine B fluorescent poly(methacrylic acid) coated gelatin nanoparticles , 2011 .

[214]  M. D. Blanco,et al.  Enhanced preclinical efficacy of tamoxifen developed as alginate-cysteine/disulfide bond reduced albumin nanoparticles. , 2012, International journal of pharmaceutics.

[215]  Miqin Zhang,et al.  Chitosan-based hydrogels for controlled, localized drug delivery. , 2010, Advanced drug delivery reviews.

[216]  Shyni Varghese,et al.  Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration. , 2007, Nature materials.

[217]  K. Tréguer,et al.  Smooth muscle cell differentiation from human bone marrow: Variations in cell type specific markers and Id gene expression in a new model of cell culture , 2009, Cell biology international.

[218]  João Rodrigues,et al.  Redox-responsive alginate nanogels with enhanced anticancer cytotoxicity. , 2013, Biomacromolecules.

[219]  J. Demeester,et al.  On the synthesis and characterization of biodegradable dextran nanogels with tunable degradation properties , 2005 .

[220]  R. Juliano,et al.  Cellular uptake and intracellular trafficking of antisense and siRNA oligonucleotides. , 2012, Bioconjugate chemistry.

[221]  K. Yadav,et al.  Effect of Size on the Biodistribution and Blood Clearance of Etoposide-Loaded PLGA Nanoparticles. , 2011, PDA journal of pharmaceutical science and technology.

[222]  W. Bentley,et al.  Enzymatic methods for in situ cell entrapment and cell release. , 2003, Biomacromolecules.

[223]  Young Ha Kim,et al.  In-vivo tumor targeting of pluronic-based nano-carriers. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[224]  R. Pandey,et al.  Pharmacokinetic and pharmacodynamic behaviour of antitubercular drugs encapsulated in alginate nanoparticles at two doses. , 2006, International journal of antimicrobial agents.

[225]  W. Hennink,et al.  The Nuclear Pore Complex: The Gateway to Successful Nonviral Gene Delivery , 2006, Pharmaceutical Research.

[226]  Zhiyuan Zhong,et al.  Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[227]  Haijun Yu,et al.  Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor. , 2013, Advanced drug delivery reviews.

[228]  Mark Emberton,et al.  Photodynamic therapy for prostate cancer—a review of current status and future promise , 2009, Nature Clinical Practice Urology.

[229]  W. Hennink,et al.  Delivery of Nucleic Acids , 2007, Pharmaceutical Research.

[230]  S. Nigam,et al.  The effect of hyaluronic acid size and concentration on branching morphogenesis and tubule differentiation in developing kidney culture systems: potential applications to engineering of renal tissues. , 2007, Biomaterials.

[231]  J. Foekens,et al.  Evaluation of the ability of adjuvant tamoxifen‐benefit gene signatures to predict outcome of hormone‐naive estrogen receptor‐positive breast cancer patients treated with tamoxifen in the advanced setting , 2014, Molecular oncology.

[232]  Y. Joung,et al.  Intracellular delivery and anti-cancer effect of self-assembled heparin-Pluronic nanogels with RNase A. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[233]  I. Haririan,et al.  Evaluation of Alginate/Chitosan nanoparticles as antisense delivery vector: Formulation, optimization and in vitro characterization , 2009 .

[234]  L. Juillerat-Jeanneret,et al.  Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[235]  Yuquan Wei,et al.  The enhanced antitumor effects of biodegradable cationic heparin-polyethyleneimine nanogels delivering HSulf-1 gene combined with cisplatin on ovarian cancer. , 2012, International journal of oncology.

[236]  Scott H. Medina,et al.  Dendrimers as carriers for delivery of chemotherapeutic agents. , 2009, Chemical reviews.

[237]  Young Ha Kim,et al.  One pot, single phase synthesis of thermo-sensitive nano-carriers by photo-crosslinking of a diacrylated pluronic , 2008 .

[238]  Sadhna Sharma,et al.  Chemotherapeutic evaluation of alginate nanoparticle-encapsulated azole antifungal and antitubercular drugs against murine tuberculosis. , 2007, Nanomedicine : nanotechnology, biology, and medicine.

[239]  T. Niidome,et al.  A polyion complex nanogel. , 2013, Journal of colloid and interface science.

[240]  In‐San Kim,et al.  Mineralized hyaluronic acid nanoparticles as a robust drug carrier , 2011 .

[241]  Junfeng Zhang,et al.  A pH/enzyme-responsive tumor-specific delivery system for doxorubicin. , 2010, Biomaterials.

[242]  Ujwala A. Shinde,et al.  Characterization of Gelatin-Sodium Alginate Complex Coacervation System , 2009, Indian journal of pharmaceutical sciences.

[243]  G. Lapienis Star-shaped polymers having PEO arms , 2009 .

[244]  B. Youan,et al.  Engineering tenofovir loaded chitosan nanoparticles to maximize microbicide mucoadhesion. , 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[245]  J. L. Turner,et al.  Fabrication of hybrid nanocapsules by calcium phosphate mineralization of shell cross-linked polymer micelles and nanocages. , 2005, Nano letters.

[246]  Ronald J Neufeld,et al.  Tuneable semi-synthetic network alginate for absorptive encapsulation and controlled release of protein therapeutics. , 2010, Biomaterials.

[247]  M. Calderón,et al.  Thermosensitive nanogels based on dendritic polyglycerol and N-isopropylacrylamide for biomedical applications , 2011 .

[248]  Eun Seong Lee,et al.  A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: in vitro evaluation. , 2010, Colloids and surfaces. B, Biointerfaces.

[249]  Jayanth Panyam,et al.  Biodegradable nanoparticles for drug and gene delivery to cells and tissue. , 2003, Advanced drug delivery reviews.

[250]  S. Vinogradov Polymeric nanogel formulations of nucleoside analogs , 2007, Expert opinion on drug delivery.

[251]  K. Akiyoshi,et al.  Interaction of nanogel with cyclodextrin or protein: Study by dynamic light scattering and small-angle neutron scattering , 2009 .

[252]  Erlong Zhang,et al.  A review of NIR dyes in cancer targeting and imaging. , 2011, Biomaterials.

[253]  J. Hubbell,et al.  Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering , 2005, Nature Biotechnology.

[254]  Y. Joung,et al.  Disulfide-crosslinked heparin-pluronic nanogels as a redox-sensitive nanocarrier for intracellular protein delivery , 2011 .

[255]  S. D. De Smedt,et al.  Protein release from biodegradable dextran nanogels. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[256]  M. D. Blanco,et al.  Tamoxifen-loaded thiolated alginate-albumin nanoparticles as antitumoral drug delivery systems. , 2012, Journal of biomedical materials research. Part A.

[257]  Y. Iwasaki,et al.  Design of hybrid hydrogels with self-assembled nanogels as cross-linkers: interaction with proteins and chaperone-like activity. , 2005, Biomacromolecules.

[258]  Hong Wu,et al.  Folate-decorated maleilated pullulan-doxorubicin conjugate for active tumor-targeted drug delivery. , 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[259]  Jiaming Zhuang,et al.  Polymer nanogels: a versatile nanoscopic drug delivery platform. , 2012, Advanced drug delivery reviews.

[260]  J. Au,et al.  Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor. , 2012, Advanced drug delivery reviews.

[261]  Gerrit Borchard,et al.  Uptake studies in rat Peyer's patches, cytotoxicity and release studies of alginate coated chitosan nanoparticles for mucosal vaccination. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[262]  Morteza Mahmoudi,et al.  Assessing the in vitro and in vivo toxicity of superparamagnetic iron oxide nanoparticles. , 2012, Chemical reviews.

[263]  David J Mooney,et al.  Spatiotemporal control over growth factor signaling for therapeutic neovascularization. , 2007, Advanced drug delivery reviews.

[264]  K. Landfester,et al.  Enzymatically degradable nanogels by inverse miniemulsion copolymerization of acrylamide with dextran methacrylates as crosslinkers , 2012 .

[265]  Nicolas Bertrand,et al.  The journey of a drug-carrier in the body: an anatomo-physiological perspective. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[266]  R. Regmi,et al.  Hyperthermia controlled rapid drug release from thermosensitive magnetic microgels , 2010 .

[267]  Y. Iwasaki,et al.  Hybrid nanogels with physical and chemical cross-linking structures as nanocarriers. , 2005, Macromolecular bioscience.

[268]  K. Kataoka,et al.  Biodegradable nanogels prepared by atom transfer radical polymerization as potential drug delivery carriers: synthesis, biodegradation, in vitro release, and bioconjugation. , 2007, Journal of the American Chemical Society.

[269]  A. Høgset,et al.  Prolonged gene silencing by combining siRNA nanogels and photochemical internalization. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[270]  K. Akiyoshi,et al.  Functional cycloamylose as a polysaccharide-based biomaterial: application in a gene delivery system. , 2010, Biomacromolecules.

[271]  S. Mohapatra,et al.  A chitosan-modified graphene nanogel for noninvasive controlled drug release. , 2013, Nanomedicine : nanotechnology, biology, and medicine.

[272]  M. Tabrizian,et al.  Cell line-dependent internalization pathways and intracellular trafficking determine transfection efficiency of nanoparticle vectors. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[273]  R. Banerjee,et al.  Biopolymer-based hydrogels for cartilage tissue engineering. , 2011, Chemical reviews.

[274]  S. Myers,et al.  The Role of Hyaluronic Acid in Wound Healing , 2005, American journal of clinical dermatology.

[275]  Bin Lai,et al.  Disulfide core cross-linked PEGylated polypeptide nanogel prepared by a one-step ring opening copolymerization of N-carboxyanhydrides for drug delivery. , 2011, Macromolecular bioscience.

[276]  K. Na,et al.  Thermo-sensitivity and triggered drug release of polysaccharide nanogels derived from pullulan-g-poly(l-lactide) copolymers , 2012 .

[277]  J. Kennedy,et al.  Pullulan: Microbial sources, production and applications. , 2008, Carbohydrate polymers.

[278]  M. M. Chen,et al.  Self-aggregated Nanoparticles of Cholesterol-modified Pullulan Conjugate as a Novel Carrier of Mitoxantronep , 2010 .

[279]  Jie Chen,et al.  Size-dependent radiosensitization of PEG-coated gold nanoparticles for cancer radiation therapy. , 2012, Biomaterials.

[280]  B. Sproat,et al.  PEGylation of biodegradable dextran nanogels for siRNA delivery. , 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[281]  K. Akiyoshi,et al.  Cell specific peptide-conjugated polysaccharide nanogels for protein delivery. , 2011, Macromolecular bioscience.

[282]  M. Moeller,et al.  Biocompatible and degradable nanogels via oxidation reactions of synthetic thiomers in inverse miniemulsion , 2009 .

[283]  K. Aoki,et al.  Peptide-based delivery to bone. , 2012, Advanced drug delivery reviews.

[284]  Bruno Sarmento,et al.  Characterization of insulin-loaded alginate nanoparticles produced by ionotropic pre-gelation through DSC and FTIR studies , 2006 .

[285]  T. Kissel,et al.  Self-assembled biodegradable amphiphilic PEG-PCL-lPEI triblock copolymers at the borderline between micelles and nanoparticles designed for drug and gene delivery. , 2011, Biomaterials.

[286]  Xiaobin Fan,et al.  Temperature- and redox-directed multiple self assembly of poly(N-isopropylacrylamide) grafted dextran nanogels. , 2011, Macromolecular rapid communications.

[287]  Eun Seong Lee,et al.  A smart polysaccharide/drug conjugate for photodynamic therapy. , 2011, Angewandte Chemie.

[288]  Jean-Luc Coll,et al.  Physico-chemical parameters that govern nanoparticles fate also dictate rules for their molecular evolution. , 2012, Advanced drug delivery reviews.

[289]  T. Delair Colloidal polyelectrolyte complexes of chitosan and dextran sulfate towards versatile nanocarriers of bioactive molecules. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[290]  Gaurav Sahay,et al.  Endocytosis of nanomedicines. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[291]  K. Na,et al.  Cancer cell specific targeting of nanogels from acetylated hyaluronic acid with low molecular weight. , 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[292]  Heparin activates PKR by inducing dimerization. , 2011, Journal of molecular biology.

[293]  Maryam Tabrizian,et al.  Effects of alginate inclusion on the vector properties of chitosan-based nanoparticles. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[294]  A. Carr,et al.  Effect of indomethacin and lactoferrin on human tenocyte proliferation and collagen formation in vitro. , 2014, Biochemical and biophysical research communications.

[295]  G. Peters,et al.  Combination therapy with gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, gemcitabine and cisplatin in patients with advanced solid tumors. , 2004, Annals of oncology : official journal of the European Society for Medical Oncology.

[296]  K. Akiyoshi,et al.  Nano-encapsulation of lipase by self-assembled nanogels: induction of high enzyme activity and thermal stabilization. , 2010, Macromolecular bioscience.

[297]  K. Tam,et al.  Control of burst release from nanogels via layer by layer assembly. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[298]  K. Matyjaszewski,et al.  Synthesis and biodegradation of nanogels as delivery carriers for carbohydrate drugs. , 2007, Biomacromolecules.

[299]  K. Na,et al.  Potential of self-organizing nanogel with acetylated chondroitin sulfate as an anti-cancer drug carrier. , 2010, Colloids and surfaces. B, Biointerfaces.

[300]  V. Choudhary,et al.  Interpenetrating polymer network (IPN) nanogels based on gelatin and poly(acrylic acid) by inverse miniemulsion technique: synthesis and characterization. , 2011, Colloids and Surfaces B: Biointerfaces.

[301]  Koen Raemdonck,et al.  Advanced nanogel engineering for drug delivery , 2009 .

[302]  Felix Kratz,et al.  Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[303]  Eun Seong Lee,et al.  Self-organized nanogels responding to tumor extracellular pH: pH-dependent drug release and in vitro cytotoxicity against MCF-7 cells. , 2007, Bioconjugate chemistry.

[304]  J. Ying,et al.  Cell immobilization in gelatin-hydroxyphenylpropionic acid hydrogel fibers. , 2009, Biomaterials.

[305]  M. D. Blanco,et al.  Synthesis and characterization of thiolated alginate-albumin nanoparticles stabilized by disulfide bonds. Evaluation as drug delivery systems , 2011 .

[306]  Jun Fang,et al.  The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. , 2011, Advanced drug delivery reviews.

[307]  Qiang Zhang,et al.  Galactose-decorated pH-responsive nanogels for hepatoma-targeted delivery of oridonin. , 2011, Biomacromolecules.

[308]  Junnian Zheng,et al.  A novel approach to overcome temozolomide resistance in glioma and melanoma: Inactivation of MGMT by gene therapy. , 2011, Biochemical and biophysical research communications.

[309]  Haiqiang Jin,et al.  Ultrasound-triggered thrombolysis using urokinase-loaded nanogels. , 2012, International journal of pharmaceutics.

[310]  João Rodrigues,et al.  Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications. , 2012, Chemical Society reviews.

[311]  I. Haririan,et al.  Inhibition of EGFR expression with chitosan/alginate nanoparticles encapsulating antisense oligonucleotides in T47D cell line using RT-PCR and immunocytochemistry , 2010 .

[312]  Richard G. W. Anderson,et al.  Caveolin, a protein component of caveolae membrane coats , 1992, Cell.

[313]  Y. Bae,et al.  pH-sensitivity and pH-dependent interior structural change of self-assembled hydrogel nanoparticles of pullulan acetate/oligo-sulfonamide conjugate. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[314]  Joon-Hee Lee,et al.  Glutathione Reductase and a Mitochondrial Thioredoxin Play Overlapping Roles in Maintaining Iron-Sulfur Enzymes in Fission Yeast , 2006, Eukaryotic Cell.

[315]  P. Ma,et al.  Functionalized synthetic biodegradable polymer scaffolds for tissue engineering. , 2012, Macromolecular bioscience.

[316]  D. Selkoe,et al.  Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide , 2007, Nature Reviews Molecular Cell Biology.

[317]  J. Kopeček Hydrogel biomaterials: a smart future? , 2007, Biomaterials.

[318]  Yuhan Lee,et al.  Thermally triggered intracellular explosion of volume transition nanogels for necrotic cell death. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[319]  Wim E Hennink,et al.  Biodegradable polymers as non-viral carriers for plasmid DNA delivery. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[320]  A. Florence Reductionism and complexity in nanoparticle-vectored drug targeting. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[321]  G. Giaccone Twenty-five years of treating advanced NSCLC: what have we achieved? , 2004, Annals of oncology : official journal of the European Society for Medical Oncology.

[322]  B. Nanjwade,et al.  Preparation and evaluation of carboplatin biodegradable polymeric nanoparticles. , 2010, International journal of pharmaceutics.

[323]  B. Sarmento,et al.  Facilitated nanoscale delivery of insulin across intestinal membrane models. , 2011, International journal of pharmaceutics.

[324]  Sílvia A. Ferreira,et al.  Self‐assembled dextrin nanogel as protein carrier: Controlled release and biological activity of IL‐10 , 2011, Biotechnology and bioengineering.

[325]  H. Dai,et al.  Soluble single-walled carbon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design. , 2007, Journal of the American Chemical Society.

[326]  S. Ishida,et al.  Disposition of glycyrrhizin in the perfused liver of rats. , 1994, Biological and Pharmaceutical Bulletin.

[327]  Cristina Carvalho,et al.  Doxorubicin: the good, the bad and the ugly effect. , 2009, Current medicinal chemistry.

[328]  P. Meier,et al.  Interactions of glycyrrhizin with organic anion transporting polypeptides of rat and human liver. , 2003, Hepatology research : the official journal of the Japan Society of Hepatology.

[329]  K. Akiyoshi,et al.  Construction of protein-crosslinked nanogels with vitamin B6 bearing polysaccharide , 2011 .

[330]  V. Lokeshwar,et al.  Differences in hyaluronic acid-mediated functions and signaling in arterial, microvessel, and vein-derived human endothelial cells. , 2000, The Journal of biological chemistry.

[331]  Shih-Hsun Cheng,et al.  pH-controllable release using functionalized mesoporous silica nanoparticles as an oral drug delivery system , 2011 .

[332]  Shengmin Zhang,et al.  Biodegradation, biocompatibility, and drug delivery in poly(ω-pentadecalactone-co-p-dioxanone) copolyesters. , 2011, Biomaterials.

[333]  Eun Seong Lee,et al.  3-Diethylaminopropyl-bearing glycol chitosan as a protein drug carrier. , 2011, Colloids and surfaces. B, Biointerfaces.

[334]  Konstantin Sokolov,et al.  Preventing protein adsorption and macrophage uptake of gold nanoparticles via a hydrophobic shield. , 2012, ACS nano.

[335]  Y. Tabata,et al.  Immunological tolerance in a mouse model of immune-mediated liver injury induced by 16,16 dimethyl PGE2 and PGE2-containing nanoscale hydrogels. , 2011, Biomaterials.

[336]  Mark R. Wilson,et al.  Roles of extracellular chaperones in amyloidosis. , 2012, Journal of molecular biology.

[337]  A. Kabanov,et al.  Nanogels as pharmaceutical carriers: finite networks of infinite capabilities. , 2009, Angewandte Chemie.

[338]  P. Couvreur Nanoparticles in drug delivery: past, present and future. , 2013, Advanced drug delivery reviews.

[339]  E. Otsuji,et al.  Raspberry-like assembly of cross-linked nanogels for protein delivery. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[340]  Vladimir P Torchilin,et al.  Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery. , 2008, Biopolymers.

[341]  L. Grover,et al.  Reversible mitotic and metabolic inhibition following the encapsulation of fibroblasts in alginate hydrogels. , 2009, Biomaterials.

[342]  Abdullah-Al-Nahain,et al.  Development of disulfide core-crosslinked pluronic nanoparticles as an effective anticancer-drug-delivery system. , 2011, Macromolecular bioscience.

[343]  Ling Zhou,et al.  Drug-loaded chondroitin sulfate-based nanogels: preparation and characterization. , 2012, Colloids and surfaces. B, Biointerfaces.

[344]  Athanasios Mantalaris,et al.  The use of murine embryonic stem cells, alginate encapsulation, and rotary microgravity bioreactor in bone tissue engineering. , 2009, Biomaterials.

[345]  J. Haddad,et al.  Redox- and oxidant-mediated regulation of interleukin-10: an anti-inflammatory, antioxidant cytokine? , 2002, Biochemical and biophysical research communications.

[346]  Kwangmeyung Kim,et al.  Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: synthesis, characterization, and in vivo biodistribution , 2009 .

[347]  James F. Leary,et al.  Tumor-targeting hyaluronic acid nanoparticles for photodynamic imaging and therapy. , 2012, Biomaterials.

[348]  J. Ndungu,et al.  Targeted delivery of paclitaxel to tumor cells: synthesis and in vitro evaluation. , 2010, Journal of medicinal chemistry.

[349]  K. J. Grande-Allen,et al.  Review. Hyaluronan: a powerful tissue engineering tool. , 2006, Tissue engineering.

[350]  K. Akiyoshi,et al.  Injectable hydrogel for sustained protein release by salt-induced association of hyaluronic acid nanogel. , 2012, Macromolecular bioscience.

[351]  Christine Wandrey,et al.  Cell response to the exposure to chitosan-TPP//alginate nanogels. , 2011, Biomacromolecules.

[352]  Zhiyuan Zhong,et al.  Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery. , 2013, Biomaterials.

[353]  G. P. Agrawal,et al.  Gelatin nanocarriers as potential vectors for effective management of tuberculosis. , 2010, International journal of pharmaceutics.

[354]  Shi Xu,et al.  Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances. , 2013, Advanced drug delivery reviews.

[355]  D. Maysinger,et al.  The binding of pullulan modified cholesteryl nanogels to Abeta oligomers and their suppression of cytotoxicity. , 2009, Biomaterials.

[356]  H. Taguchi,et al.  Comparison of refolding activities between nanogel artificial chaperone and GroEL systems. , 2008, International journal of biological macromolecules.

[357]  Andreas Zimmer,et al.  Drug delivery of siRNA therapeutics: potentials and limits of nanosystems. , 2009, Nanomedicine : nanotechnology, biology, and medicine.

[358]  K. Akiyoshi,et al.  Polysaccharide nanogel gene delivery system with endosome-escaping function: Co-delivery of plasmid DNA and phospholipase A2. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[359]  Y. Ha,et al.  Chitosan/TPP-Hyaluronic Acid Nanoparticles: A New Vehicle for Gene Delivery to the Spinal Cord , 2012, Journal of biomaterials science. Polymer edition.

[360]  R. Hidalgo-Álvarez,et al.  Cationic polymer nanoparticles and nanogels: from synthesis to biotechnological applications. , 2014, Chemical reviews.

[361]  M. Morris,et al.  A peptide carrier for the delivery of biologically active proteins into mammalian cells , 2001, Nature Biotechnology.

[362]  D. Grainger,et al.  A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity. , 2012, Pharmacology & therapeutics.