Generalized Cortico‐Reticular Epilepsies Some Considerations on the Pathophysiology of Generalized Bilaterally Synchronous Spike and Wave Discharge

Results of the intracarotid and intravertebral injection of metrazol and sodium amytal in patients with generalized seizures associated with generalized bilaterally synchronous spike and wave discharges, suggest that cortical mechanisms are very important for the physiopathogenesis of these seizures. It seems, however, unjustified to exclude reticular brain stem and thalamic mechanisms entirely, since the animal experimental evidence supporting their role in the mechanism of the generalized bilaterally synchronous spike and wave discharges is very strong.

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