A conditionally replicating adenovirus targeted to tumor cells through activated RAS/P-MAPK-selective mRNA stabilization

[1]  S. Prescott,et al.  Many actions of cyclooxygenase‐2 in cellular dynamics and in cancer , 2002, Journal of cellular physiology.

[2]  F. McCormick,et al.  Replication-selective viruses for cancer therapy , 2002, Journal of Molecular Medicine.

[3]  T. Clackson,et al.  A system for small-molecule control of conditionally replication-competent adenoviral vectors. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

[4]  Y. Bakhle.  COX‐2 and cancer: a new approach to an old problem , 2001, British journal of pharmacology.

[5]  G. Demers,et al.  Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy , 2001, Nature Biotechnology.

[6]  R. Martuza,et al.  Replication-selective virotherapy for cancer: Biological principles, risk management and future directions , 2001, Nature Medicine.

[7]  D. Curiel,et al.  Genetic Targeting of an Adenovirus Vector via Replacement of the Fiber Protein with the Phage T4 Fibritin , 2001, Journal of Virology.

[8]  H. Sheng,et al.  K-Ras-mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B1. , 2001, Cancer research.

[9]  R. Alemany,et al.  Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancers. , 2001, Molecular therapy : the journal of the American Society of Gene Therapy.

[10]  J. Saklatvala,et al.  Regulation of tumour necrosis factor α mRNA stability by the mitogen‐activated protein kinase p38 signalling cascade , 2000, FEBS letters.

[11]  D. Brough,et al.  Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen. , 2000, The Journal of clinical investigation.

[12]  C. Balagué,et al.  Replicative adenoviruses for cancer therapy , 2000, Nature Biotechnology.

[13]  L. Meisner,et al.  Amplification in human breast cancer of a gene encoding a c-myc mRNA-binding protein. , 2000, Cancer research.

[14]  Thomas M. McIntyre,et al.  Post-transcriptional Control of Cyclooxygenase-2 Gene Expression , 2000, The Journal of Biological Chemistry.

[15]  A. Maity,et al.  Both increased stability and transcription contribute to the induction of the urokinase plasminogen activator receptor (uPAR) message by hypoxia. , 2000, Experimental cell research.

[16]  A Cestelli,et al.  RNA-protein interactions in the control of stability and localization of messenger RNA (review). , 2000, International journal of molecular medicine.

[17]  Y. Chiang,et al.  A novel tumor-specific replication-restricted adenoviral vector for gene therapy of hepatocellular carcinoma. , 1999, Human gene therapy.

[18]  V. Ling,et al.  Increased P‐glycoprotein messenger RNA stability in rat liver tumors in vivo , 1998, Journal of cellular physiology.

[19]  H. Sheng,et al.  Induction of Cyclooxygenase-2 by Activated Ha-rasOncogene in Rat-1 Fibroblasts and the Role of Mitogen-activated Protein Kinase Pathway* , 1998, The Journal of Biological Chemistry.

[20]  K. Chébli,et al.  A Novel Phosphorylation-Dependent RNase Activity of GAP-SH3 Binding Protein: a Potential Link between Signal Transduction and RNA Stability , 1998, Molecular and Cellular Biology.

[21]  Y. Lee,et al.  Adenoviral-mediated transfer of a heat-inducible double suicide gene into prostate carcinoma cells. , 1998, Cancer research.

[22]  M. Detmar,et al.  Identification of a human VPF/VEGF 3' untranslated region mediating hypoxia-induced mRNA stability. , 1998, Molecular biology of the cell.

[23]  J. Morrow,et al.  A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells. , 1997, Gastroenterology.

[24]  I. Verma,et al.  Gene therapy - promises, problems and prospects , 1997, Nature.

[25]  J. Simons,et al.  Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells. , 1997, Cancer research.

[26]  K. Skorecki,et al.  Induction of Cytosolic Phospholipase A2 by Oncogenic Ras in Human Non-small Cell Lung Cancer* , 1997, The Journal of Biological Chemistry.

[27]  H. Sheng,et al.  Cyclooxygenase-2 induction and transforming growth factor beta growth inhibition in rat intestinal epithelial cells. , 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[28]  R. Muschel,et al.  Cyclin A message stability varies with the cell cycle. , 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[29]  R. Fenton,et al.  Transcriptional targeting of recombinant adenoviruses to human and murine melanoma cells. , 1996, Cancer research.

[30]  H. Hurst,et al.  Suicide gene expression induced in tumour cells transduced with recombinant adenoviral, retroviral and plasmid vectors containing the ERBB2 promoter. , 1996, Gene therapy.

[31]  A. Fattaey,et al.  An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells , 1996, Science.

[32]  C. Y. Chen,et al.  AU-rich elements: characterization and importance in mRNA degradation. , 1995, Trends in biochemical sciences.

[33]  J. Ross,et al.  mRNA stability in mammalian cells. , 1995, Microbiological reviews.

[34]  R. Muschel,et al.  Evidence for post‐transcriptional regulation of cyclin B1 mRNA in the cell cycle and following irradiation in HeLa cells. , 1995, The EMBO journal.

[35]  R. Kefford,et al.  Transcriptional and posttranscriptional activation of urokinase plasminogen activator gene expression in metastatic tumor cells. , 1992, Cancer research.

[36]  N. Sato,et al.  Cytokine messenger RNA stability is enhanced in tumor cells. , 1991, Blood.

[37]  S. Bauer,et al.  Altered myc gene transcription and intron-induced stabilization of myc RNAs in two mouse plasmacytomas. , 1989, Oncogene.

[38]  C. Thompson,et al.  Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. , 1989, Science.

[39]  D. Schümperli,et al.  3' processing of pre-mRNA plays a major role in proliferation-dependent regulation of histone gene expression. , 1988, Nucleic acids research.

[40]  G. Shaw,et al.  A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation , 1986, Cell.

[41]  B. Beutler,et al.  Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[42]  H. Sidransky,et al.  Turnover of messenger RNA in transplantable hepatomas and host liver of rats. , 1978, Cancer research.

[43]  R. DuBois,et al.  Cyclooxygenase-2: a therapeutic target. , 2002, Annual review of medicine.

[44]  N R Lemoine,et al.  Cancer gene therapy: hard lessons and new courses , 2000, Gene Therapy.

[45]  D. Dixon,et al.  Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. , 2000, The Journal of biological chemistry.

[46]  Y. Nagamine,et al.  Cell Invasion in Vitro Stability and uPA-dependent Urokinase-Type Plasminogen Activator ( uPA ) Messenger RNA Adenylate-and Uridylate-Rich Element-mediated Regulation by p 38 Mitogen-activated Protein Kinase of Updated Version , 1999 .

[47]  M. Lieberman,et al.  Two genes associated with liver cancer are regulated by different mechanisms in rasT24 transformed liver epithelial cells. , 1989, Oncogene.