Testicular function in men treated in childhood for undescended testes.

PURPOSE The aim of the study was to evaluate testicular hormones and sperm counts of young men treated in childhood for cryptorchidism METHODS Testicular volume, serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone as well as semen specimens were evaluated in 57 men (mean age, 19 years; range, 18 to 27 years) treated in childhood for unilateral (n = 47) and bilateral (n = 10) cryptorchidism. In 3 unilateral cases monorchidism was found. Thirty-seven patients underwent orchiopexy after hormonal treatment (luteinizing hormone releasing factor, 1.2 mg/d for 28 days followed by human chorionic gonadotropin, 500 IU intramuscularly 3 times a week for 3 weeks). The remainder underwent surgery. Mean age at surgical treatment was 5.4 years (range, 2 to 12 years). These patients were examinated again after a mean period of 13.3 years (range, 10 to 19 years). RESULTS Reduced testicular volume (<12 mL) was found in 6 of 64 testes (9.3%). LH, FSH, and testosterone levels were found within the normal range in all patients. With linear regression, inverse relations were found between FSH and, respectively, testicular volume (P =.002), sperm concentration (P =.013), sperm motility (P =.023), and normally shaped sperms (P =.019). There were direct relations between testicular volume and sperm concentration (P =.02), sperm motility (P =.000), and normally shaped sperms (P =.001). We did not find any statistical correlation between age at surgery and semen quality. Significantly better results in terms of sperm counts were found in patients directly operated on in comparison to those treated with hormones before orchiopexy. CONCLUSIONS Presented data indicate tubular impairment in young men operated on in childhood for cryptorchidism; FSH values increase and testicular volume decrease are related to sperm deterioration. Studies on children treated in the first 2 years of life are required to clarify the usefulness of early treatment of cryptorchidism.

[1]  P. A. Lee,et al.  Age at unilateral orchiopexy: effect on hormone levels and sperm count in adulthood. , 1999, The Journal of urology.

[2]  T. Stijnen,et al.  Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1998 by The Endocrine Society Serum Inhibin B as a Marker of Spermatogenesis , 2022 .

[3]  R. Lala,et al.  Early hormonal and surgical treatment of cryptorchidism. , 1997, The Journal of urology.

[4]  R. Lala,et al.  Non-Palpable Testes. Orchiopexy in Single Stage , 1995, European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie.

[5]  P. Lee.  Fertility in cryptorchidism. Does treatment make a difference? , 1993, Endocrinology and metabolism clinics of North America.

[6]  W. Hendry.  The significance of antisperm antibodies: measurement and management , 1992, Clinical endocrinology.

[7]  P. Brown,et al.  Fertility after orchiopexy for cryptorchidism: a new approach to assessment. , 1989, British journal of urology.

[8]  G. Saggese,et al.  Hormonal therapy for cryptorchidism with a combination of human chorionic gonadotropin and follicle-stimulating hormone. Success and relapse rate. , 1989, American journal of diseases of children.

[9]  C. Koop,et al.  Cryptorchidism, orchiopexy and infertility: a critical long-term retrospective analysis. , 1989, The Journal of urology.

[10]  P. Puri,et al.  SEMEN ANALYSIS OF PATIENTS WHO HAD ORCHIDOPEXY AT OR AFTER SEVEN YEARS OF AGE , 1988, The Lancet.

[11]  E. Bertoft,et al.  Determination of hormones by time-resolved fluoroimmunoassay. , 1984, Talanta.

[12]  Keith D. Smith,et al.  Frequency distribution of sperm counts in fertile and infertile males. , 1977, Fertility and sterility.

[13]  W. Mengel,et al.  Studies on cryptorchidism: a comparison of histological findings in the germinative epithelium before and after the second year of life. , 1974, Journal of pediatric surgery.

[14]  D. Mattingly,et al.  HOW MANY LADDERS? , 1964, Lancet.

[15]  E. Page,et al.  The clinical interpretation of 1000 semen analyses among applicants for sterility studies. , 1951, Fertility and sterility.