Determination of photothermal conversion efficiency of graphene and graphene oxide through an integrating sphere method

Abstract We report a new method for the determination of photothermal conversion efficiency of photothermal agents, based on the use of an integrating sphere. We validated this method by comparing the photothermal conversion efficiency of Au nanorods calculated by this method and by the more conventional time constant method. Then, we applied this method to determine the photothermal conversion efficiency of graphene and graphene oxide nanosheets dispersions in dimethylformamide and water, respectively, finding out that they are excellent photothermal agents with photothermal conversion efficiencies among the highest reported up to now. We also analyzed the influence of the concentration of the materials, and the wavelength and power of irradiation in the temperature increase that can be achieved with them, finding out that they can be used, for instance, in cancer treatment through hyperthermia procedures with reduced costs when compared to other photothermal agents.

[1]  I. Tsai,et al.  Numerous single-layer graphene sheets prepared from natural graphite by non-chemical liquid-phase exfoliation , 2014 .

[2]  Glenn P. Goodrich,et al.  Photothermal Efficiencies of Nanoshells and Nanorods for Clinical Therapeutic Applications , 2009 .

[3]  M. Hoepfner,et al.  Microscale Heat Transfer Transduced by Surface Plasmon Resonant Gold Nanoparticles. , 2007, The journal of physical chemistry. C, Nanomaterials and interfaces.

[4]  Fuyou Li,et al.  NIR photothermal therapy using polyaniline nanoparticles. , 2013, Biomaterials.

[5]  Jiye Cai,et al.  Facile solution routes for the syntheses of water-dispersable germanium nanoparticles and their biological applications , 2013 .

[6]  Zeljko Vujaskovic,et al.  Randomized trial of hyperthermia and radiation for superficial tumors. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[7]  P. Wust,et al.  Hyperthermia in combined treatment of cancer. , 2002, The Lancet Oncology.

[8]  Matthew G. Panthani,et al.  Copper selenide nanocrystals for photothermal therapy. , 2011, Nano letters.

[9]  N. Zheng,et al.  Sub-10-nm Pd nanosheets with renal clearance for efficient near-infrared photothermal cancer therapy. , 2014, Small.

[10]  James W Tunnell,et al.  Nanoparticle‐mediated photothermal therapy: A comparative study of heating for different particle types , 2012, Lasers in surgery and medicine.

[11]  M. Bawendi,et al.  Renal clearance of quantum dots , 2007, Nature Biotechnology.

[12]  Elena D. Obraztsova,et al.  Efficient nitrogen doping of graphene by plasma treatment , 2016 .

[13]  B. Kong,et al.  Tungsten Oxide Nanorods: An Efficient Nanoplatform for Tumor CT Imaging and Photothermal Therapy , 2014, Scientific Reports.

[14]  J. Lepock,et al.  Thermal analysis of CHL V79 cells using differential scanning calorimetry: Implications for hyperthermic cell killing and the heat shock response , 1988, Journal of cellular physiology.

[15]  Liang Cheng,et al.  Conjugated polymers for photothermal therapy of cancer , 2014 .

[16]  Zhe Wang,et al.  Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy. , 2013, Angewandte Chemie.

[17]  Lisha Zhang,et al.  980‐nm Laser‐Driven Photovoltaic Cells Based on Rare‐Earth Up‐Converting Phosphors for Biomedical Applications , 2009 .

[18]  Kai Yang,et al.  The influence of surface chemistry and size of nanoscale graphene oxide on photothermal therapy of cancer using ultra-low laser power. , 2012, Biomaterials.

[19]  M. C. Mancini,et al.  Bioimaging: second window for in vivo imaging. , 2009, Nature nanotechnology.

[20]  R. Nordquist,et al.  Laser-photosensitizer assisted immunotherapy: a novel modality for cancer treatment. , 1997, Cancer letters.

[21]  Z. Dai,et al.  Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide. , 2014, Journal of materials chemistry. B.

[22]  Rujia Zou,et al.  Cu7.2S4 nanocrystals: a novel photothermal agent with a 56.7% photothermal conversion efficiency for photothermal therapy of cancer cells. , 2014, Nanoscale.

[23]  Rujia Zou,et al.  Sub-10 nm Fe3O4@Cu(2-x)S core-shell nanoparticles for dual-modal imaging and photothermal therapy. , 2013, Journal of the American Chemical Society.

[24]  Zhuang Liu,et al.  Sub-100 nm hollow Au-Ag alloy urchin-shaped nanostructure with ultrahigh density of nanotips for photothermal cancer therapy. , 2014, Biomaterials.

[25]  Qiushi Ren,et al.  Uniform Polypyrrole Nanoparticles with High Photothermal Conversion Efficiency for Photothermal Ablation of Cancer Cells , 2013, Advanced materials.

[26]  D. Krewski,et al.  Thermal therapy, part 1: an introduction to thermal therapy. , 2006, Critical reviews in biomedical engineering.

[27]  Bin Tang,et al.  A review of optical imaging and therapy using nanosized graphene and graphene oxide. , 2013, Biomaterials.

[28]  Lehui Lu,et al.  Dopamine‐Melanin Colloidal Nanospheres: An Efficient Near‐Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy , 2013, Advanced materials.

[29]  Kai Yang,et al.  Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. , 2010, Nano letters.

[30]  Dapeng Liu,et al.  Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy. , 2013, Biomaterials.

[31]  W. Fritzsche,et al.  Selection of thermo-optical parameter of nanoparticles for achievement of their maximal thermal energy under optical irradiation , 2013 .

[32]  Ji-Xin Cheng,et al.  Hyperthermic effects of gold nanorods on tumor cells. , 2007, Nanomedicine.

[33]  Omid Akhavan,et al.  Zinc ferrite spinel-graphene in magneto-photothermal therapy of cancer. , 2014, Journal of materials chemistry. B.

[34]  Yong-Min Huh,et al.  Gold nanostructures as photothermal therapy agent for cancer. , 2011, Anti-cancer agents in medicinal chemistry.

[35]  J. G. Solé,et al.  Intratumoral Thermal Reading During Photo‐Thermal Therapy by Multifunctional Fluorescent Nanoparticles , 2015 .

[36]  Yong-Chien Ling,et al.  Graphene-based photothermal agent for rapid and effective killing of bacteria. , 2013, ACS nano.

[37]  Omid Akhavan,et al.  Graphene nanomesh promises extremely efficient in vivo photothermal therapy. , 2013, Small.

[38]  K. Bartels,et al.  Photothermal effects on murine mammary tumors using indocyanine green and an 808-nm diode laser: an in vivo efficacy study. , 1996, Cancer letters.

[39]  H. Emamy,et al.  Nontoxic concentrations of PEGylated graphene nanoribbons for selective cancer cell imaging and photothermal therapy , 2012 .

[40]  H. Dai,et al.  Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy. , 2011, Journal of the American Chemical Society.

[41]  G. Hahn,et al.  Treatment of superficial human neoplasms by local hyperthermia induced by ultrasound , 1979, Cancer.

[42]  Kung-Hsuan Lin,et al.  Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles. , 2013, Biomaterials.

[43]  C. Yeh,et al.  Comparative efficiencies of photothermal destruction of malignant cells using antibody-coated silica@Au nanoshells, hollow Au/Ag nanospheres and Au nanorods , 2009, Nanotechnology.

[44]  Zhuang Liu,et al.  Graphene-based magnetic plasmonic nanocomposite for dual bioimaging and photothermal therapy. , 2013, Biomaterials.

[45]  M. El-Sayed,et al.  Shape and size dependence of radiative, non-radiative and photothermal properties of gold nanocrystals , 2000 .

[46]  Omid Akhavan,et al.  The use of a glucose-reduced graphene oxide suspension for photothermal cancer therapy , 2012 .

[47]  Rujia Zou,et al.  Hydrophilic Cu9S5 nanocrystals: a photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo. , 2011, ACS nano.