Rationale of the diet-heart statement of the American Heart Association. Report of Nutrition Committee.

A FUNDAMENTAL GOAL of the American Heart Association (AHA) is to prevent cardiovascular disease and, in particular, to reduce the incidence of coronary heart disease (CHD) and other atherosclerotic diseases in our society. A question of great concern to the AHA has been whether the American diet is a significant factor in the genesis of atherosclerosis. This question has been the subject of continuous dialogue within the Association for at least 25 years. Although many and frequently diverse opinions have been voiced within the several committees of the AHA, a concerted effort has been made to integrate the best available evidence on the subject. It is clear that the "diet-heart question" is complex, and new information is emerging continually. Still, a broad base of knowledge has been accrued, and because of the urgency engendered by the high incidence of CHD in the U.S., the AHA has felt a responsibility to provide the best possible guidance to the medical community and the American public on the diet question. For this reason the policy of the AHA has been to frequently update recommendations on the basis of the best currently available evidence. The rationale and documentation for particular recommendations of the AHA are discussed below.

[1]  M. L. Pearce,et al.  Incidence of cancer in men on a diet high in polyunsaturated fat. , 1971, Lancet.

[2]  P. Leren The effect of plasma-cholesterol-lowering diet in male survivors of myocardial infarction. A controlled clinical trial. , 1968, Bulletin of the New York Academy of Medicine.

[3]  M. Foulkes,et al.  Cholesterol and mortality in New Zealand Maoris. , 1980, British medical journal.

[4]  F. Hatch,et al.  Effects of diet in essential hypertension. II. Results with unmodified Kempner rice diet in 50 hospitalized patients. , 1950, The American journal of medicine.

[5]  W. Connor,et al.  Effect of dietary cholesterol upon serum lipids in man. , 1961, The Journal of laboratory and clinical medicine.

[6]  P. Wilson,et al.  Prevalence of coronary heart disease in the Framingham Offspring Study: role of lipoprotein cholesterols. , 1980, The American journal of cardiology.

[7]  M. Armstrong,et al.  Regression of Coronary Atheromatosis in Rhesus Monkeys , 1970, Circulation research.

[8]  G. Miller,et al.  PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE , 1975, The Lancet.

[9]  A. Kligman,et al.  Effect of dietary cholesterol on serum cholesterol in man. , 1972, The American journal of clinical nutrition.

[10]  H. Kato,et al.  Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California. , 1973, American journal of epidemiology.

[11]  C. Program Dietary fat and its relation to heart attacks and strokes. , 1961 .

[12]  I. Bersohn,et al.  The influence of diet on serumtriglycerides in South Africa white and Bantu prisoners. , 1961, Lancet.

[13]  M. Brown,et al.  Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts. , 1975, The Journal of clinical investigation.

[14]  J. Miller,et al.  [Plasma apoprotein and lipoprotein lipid levels in vegetarians]. , 1978, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[15]  F. Sacks,et al.  Plasma lipids and lipoproteins in vegetarians and controls. , 1975, The New England journal of medicine.

[16]  A. Adelstein,et al.  Commodity consumption and ischemic heart disease mortality, with special reference to dietary practices. , 1975, Journal of chronic diseases.

[17]  A. Keys,et al.  Seven countries. A multivariate analysis of death and coronary heart disease. , 1980 .

[18]  E. R. Plunkett,et al.  Effects of dietary fat on mammary carcinogenesis by 7,12-dimethylbenz(alpha)anthracene in rats. , 1967, Cancer research.

[19]  H. Lofland,et al.  Atherosclerosis in Cebus albifrons monkeys. [. Clinical and pathologic studies. , 1969, Experimental and molecular pathology.

[20]  A. Smith,et al.  The relationship of serum cholesterol to the incidence of cancer in Evans County, Georgia. , 1980, Journal of chronic diseases.

[21]  I. Page,et al.  Atherosclerosis and the Fat Content of the Diet , 1957, Journal of the American Medical Association.

[22]  G. Mann Diet-Heart: end of an era. , 1977, The New England journal of medicine.

[23]  H. Tyroler,et al.  Black-white differences in serum lipids and lipoproteins in Evans County. , 1975, Preventive medicine.

[24]  C. Tejada,et al.  Comparison of atherosclerosis in Guatemala City and New Orleans. , 1957, The American journal of pathology.

[25]  W. Kannel,et al.  Colon cancer and blood-cholesterol. , 1974, Lancet.

[26]  A. Keys,et al.  Serum cholesterol response to changes in the diet: IV. Particular saturated fatty acids in the diet. , 1965, Metabolism: clinical and experimental.

[27]  C. Tejada,et al.  Serum Lipoprotein and Cholesterol Concentrations: Comparison of Rural Costa Rican, Guatemalan, and United States Populations , 1957, Circulation.

[28]  E. H. Ahrens Drugs Spotlight Program: The Management of Hyperlipidemia: Whether, Rather than How , 1976 .

[29]  M. Kornitzer,et al.  THE PATTERN OF FOOD AND MORTALITY IN BELGIUM , 1977, The Lancet.

[30]  W. Kannel,et al.  Results of the Framingham study applied to four other U.S.-based epidemiologic studies of cardiovascular disease , 1976 .

[31]  M C Hjortland,et al.  High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. , 1977, The American journal of medicine.

[32]  Z. Reinis Experimental arteriosclerosis. , 1956, Review of Czechoslovak medicine.

[33]  I. Hjermann,et al.  EFFECT OF DIET AND SMOKING INTERVENTION ON THE INCIDENCE OF CORONARY HEART DISEASE , 1981 .

[34]  M C Hjortland,et al.  Predicting coronary heart disease in middle-aged and older persons. The Framington study. , 1977, JAMA.

[35]  C. Sampson The geographic pathology of atherosclerosis. , 1969, Nutrition reviews.

[36]  The multiple risk factor intervention trial (MRFIT). A national study of primary prevention of coronary heart disease. , 1976, JAMA.

[37]  R. Gerrity,et al.  HDL-cholesterol concentration and severity of coronary atherosclerosis determined by cine-angiography. , 1980, Artery.

[38]  D. B. Zilversmit,et al.  A Proposal Linking Atherogenesis to the Interaction of Endothelial Lipoprotein Lipase with Triglyceride‐Rich Lipoproteins , 1973, Circulation research.

[39]  A. Motulsky,et al.  Plasma lipid levels and coronary heart disease in adult relatives of newborns with normal and elevated cord blood lipids. , 1974, American journal of human genetics.

[40]  D. Eggen Cholesterol metabolism in groups of rhesus monkeys with high or low response of serum cholesterol to an atherogenic diet. , 1976, Journal of lipid research.

[41]  M. Karvonen,et al.  Effect of cholesterol-lowering diet on mortality from coronary heart-disease and other causes. A twelve-year clinical trial in men and women. , 1972, Lancet.

[42]  C. Glueck,et al.  Neonatal familial hypercholesterolemia. , 1975, American journal of diseases of children.

[43]  G. Bourke,et al.  Nutritional and epidemiologic factors related to heart disease. , 1970, World review of nutrition and dietetics.

[44]  C. Glueck,et al.  Cholesterol at birth and age 1: comparison of normal and hypercholesterolemic neonates. , 1974, Pediatrics.

[45]  J. Stamler Public health aspects of optimal serum lipid-lipoprotein levels. , 1979, Preventive medicine.

[46]  H. B. Brown,et al.  EFFECT OF POLYUNSATURATED EGGS ON SERUM CHOLESTEROL. , 1965, Journal of the American Dietetic Association.

[47]  A Kagan,et al.  Serum lipoproteins and coronary heart disease in a population study of Hawaii Japanese men. , 1976, The New England journal of medicine.

[48]  P. Savage,et al.  Serum cholesterol levels in American (Pima) Indian children and adolescents. , 1976, Pediatrics.

[49]  S. Koskinen,et al.  Association of serum lipids and obesity with cardiovascular mortality. , 1977, British medical journal.

[50]  W. Connell,et al.  The response of man to dietary cholesterol. , 1960, The Journal of nutrition.

[51]  A. Keys,et al.  Prediction of serum-cholesterol responses of man to changes in fats in the diet. , 1957, Lancet.

[52]  J. Strong,et al.  Atherosclerotic lesions produced in baboons by feeding an atherogenic diet for four years. , 1976, Experimental and molecular pathology.

[53]  J. Medalie,et al.  Clinical myocardial infarction over a five-year period--III. A multivariate analysis of incidence, the Israel ischemic heart disease study. , 1975, Journal of chronic diseases.

[54]  E. Renner PATTERN OF FOOD AND MORTALITY IN BELGIUM , 1977, The Lancet.

[55]  J. Stamler Acute myocardial infarction - progress in primary prevention , 1971, British heart journal.

[56]  E. L. Wynder,et al.  EFFECT OF ENVIRONMENT ON THE SERUM CHOLESTEROL-TRIGLYCERIDE DISTRIBUTION AMONG SEVENTH-DAY ADVENTISTS. , 1964, The American journal of medicine.

[57]  M. Marion The Familial Hyperlipoproteinemias , 1975 .

[58]  P. Nestel,et al.  Severity of coronary atherosclerosis related to lipoprotein concentration. , 1978, British medical journal.

[59]  R. Sturdevant,et al.  Increased prevalence of cholelithiasis in men ingesting a serum-cholesterol-lowering diet. , 1973, The New England journal of medicine.

[60]  E. Wynder The epidemiology of large bowel cancer. , 1975, Cancer research.

[61]  Kiang Liu,et al.  DIETARY CHOLESTEROL, FAT, AND FIBRE, AND COLON-CANCER MORTALITY An Analysis of International Data , 1979, The Lancet.

[62]  W. Kannel,et al.  Cancer incidence by levels of cholesterol. , 1981, JAMA.

[63]  R. Mahley,et al.  Alterations of the plasma lipoproteins and apoproteins following cholesterol feeding in the rat. , 1977, Journal of lipid research.

[64]  D. E. Lamphiear,et al.  Daily nutritional intake and serum lipid levels. The Tecumseh study. , 1976, The American journal of clinical nutrition.

[65]  M. Shipley,et al.  PLASMA LIPIDS AND MORTALITY: A SOURCE OF ERROR , 1980, The Lancet.

[66]  T. Dawber,et al.  The Yugoslavia cardiovascular disease study. 1. The incidence of coronary heart disease by area. , 1976, Journal of chronic diseases.

[67]  S. Gershoff,et al.  Changes in serum cholesterol and coronary heart disease mortality associated with changes in the postwar Japanese diet. , 1973, The American journal of clinical nutrition.

[68]  H. Kato,et al.  Epidemiology of coronary heart disease and stroke in Japanese men living in Japan, Hawaii, and California: methodology for comparison of diet. , 1973, The American journal of clinical nutrition.

[69]  J. Mcmichael Letter: Prevention of coronary heart-disease. , 1976, Lancet.

[70]  L. Carlson,et al.  Ischaemic heart-disease in relation to fasting values of plasma triglycerides and cholesterol. Stockholm prospective study. , 1972, Lancet.

[71]  S. Syme,et al.  Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: demographic, physical, dietary and biochemical characteristics. , 1974, Journal of chronic diseases.

[72]  H. Keen,et al.  Myocardial ischaemia, risk factors and death from coronary heart-disease. , 1977, Lancet.

[73]  R. Wallace,et al.  The plasma lipids, lipoproteins, and diet of the Tarahumara indians of Mexico. , 1978, The American journal of clinical nutrition.

[74]  R. Bawol,et al.  Epidemiology as a guide to clinical decisions. The association between triglyceride and coronary heart disease. , 1980, The New England journal of medicine.

[75]  Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events: final report of the pooling project. The pooling project research group. , 1978, Journal of chronic diseases.

[76]  D. Hegsted,et al.  Quantitative effects of dietary fat on serum cholesterol in man. , 1965, The American journal of clinical nutrition.

[77]  E. Wynder,et al.  Metabolic epidemiology of large bowel cancer. Fecal bulk and constituents of high‐risk North American and low‐risk finnish population , 1978, Cancer.

[78]  J. Mcmichael Dietetic factors in coronary disease. , 1977, European journal of cardiology.

[79]  E. R. Plunkett,et al.  Dietary fat and mammary cancer. , 1968, Canadian Medical Association journal.

[80]  H. Malmros The relation of nutrition to health; a statistical study of the effect of the war-time on arteriosclerosis, cardiosclerosis, tuberculosis and diabetes. , 2009, Acta medica Scandinavica. Supplementum.

[81]  N. Scrimshaw,et al.  The serum lipoprotein and cholesterol concentrations of the Central and North Americans with different dietary habits. , 1955, The American journal of medicine.

[82]  C. Fielding Metabolism of cholesterol-rich chylomicroms. Mechanism of binding and uptake of cholesteryl esters by the vascular bed of the perfused rat heart. , 1978, The Journal of clinical investigation.

[83]  R. Levy Cholesterol, lipoproteins, apoproteins, and heart disease: present status and future prospects. , 1981, Clinical chemistry.

[84]  L. Rudel,et al.  Characterization of plasma low density lipoproteins on nonhuman primates fed dietary cholesterol. , 1977, Journal of lipid research.

[85]  J. Strong,et al.  Diet and experimental atherosclerosis in baboons. , 1967, The American journal of pathology.

[86]  S. Syme,et al.  Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: mortality. , 1975, American journal of epidemiology.

[87]  R. Brand,et al.  Multivariate prediction of coronary heart disease during 8.5 year follow-up in the Western Collaborative Group Study. , 1976, The American journal of cardiology.

[88]  W. Connor,et al.  The serum lipids in men receiving high cholesterol and cholesterol-free diets. , 1961, The Journal of clinical investigation.

[89]  A. Keys,et al.  Serum cholesterol response to changes in the diet: II. The effect of cholesterol in the diet. , 1965, Metabolism: clinical and experimental.

[90]  L. Wilhelmsen,et al.  Risk factors for myocardial infarction and death due to ischemic heart disease and other causes. , 1975, The American journal of cardiology.

[91]  R. Havel,et al.  Levels and Interrelationships of Serum and Lipoprotein Cholesterol and Triglycerides , 1981, Arteriosclerosis.

[92]  W. Raynor,et al.  Diet, serum cholesterol, and death from coronary heart disease. The Western Electric study. , 1981, The New England journal of medicine.

[93]  Diet and coronary heart disease. A council statement. , 1972, JAMA.

[94]  H. Lofland,et al.  ATHEROSCLEROSIS IN SOME SPECIES OF NEW WORLD MONKEYS * , 1969, Annals of the New York Academy of Sciences.

[95]  R. Levy,et al.  The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia. , 1972, The Journal of clinical investigation.

[96]  W. Insull,et al.  The influence of dietary fats on serum-lipid levels in man. , 1957, Lancet.

[97]  M Marmot,et al.  Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California. Incidence of myocardial infarction and death from coronary heart disease. , 1977, The American journal of cardiology.

[98]  H. Lofland,et al.  Studies on the regulation of plasma cholesterol levels in squirrel monkeys of two genotypes. , 1972, Journal of lipid research.

[99]  C. Cordova,et al.  TYPE-III HYPERLIPOPROTEINAEMIA , 1975, The Lancet.

[100]  D. Kleinbaum,et al.  Multivariate analysis of risk of coronary heart disease in Evans County, Georgia. , 1971, Archives of internal medicine.

[101]  C. Packard,et al.  Effects of dietary polyunsaturated and saturated fat on the properties of high density lipoproteins and the metabolism of apolipoprotein A-I. , 1978, The Journal of clinical investigation.

[102]  R. Worth,et al.  Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California. Coronary heart disease risk factors in Japan and Hawaii. , 1977, The American journal of cardiology.

[103]  G. Reaven,et al.  Effects of weight reduction on obesity. Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects. , 1974, The Journal of clinical investigation.

[104]  I GONTEA,et al.  [NUTRITION AND ATHEROSCLEROSIS]. , 1964, Medicina interna.

[105]  A. Harper Dietary goals-a skeptical view. , 1978, The American journal of clinical nutrition.

[106]  R. Hodges,et al.  Relationship between food consumption and mortality from atherosclerotic heart disease in Europe. , 1966, The American journal of clinical nutrition.

[107]  S. Grundy,et al.  Metabolic studies in familial hypercholesterolemia. Evidence for a gene-dosage effect in vivo. , 1979, The Journal of clinical investigation.

[108]  F. Eskin The role of the egg as a factor in the aetiology of coronary heart disease. , 1971, Community health.

[109]  W. Connell,et al.  Dietary cholesterol and plasma cholesterol levels in man. , 1959, Canadian journal of biochemistry and physiology.

[110]  A. Truswell Diet and plasma lipids--a reappraisal. , 1978, The American journal of clinical nutrition.

[111]  C. B. Taylor,et al.  Serum cholesterol levels of Seventh-day Adventists. , 1976, Paroi arterielle.

[112]  A. Motulsky,et al.  Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. , 1973, The Journal of clinical investigation.

[113]  T. Cooper Department of Health, Education, and Welfare. , 1976, Military medicine.

[114]  F. Ederer,et al.  Cancer among men on cholesterol-lowering diets: Experience from five clinical trials. , 1971, Lancet.

[115]  O. Hayes,et al.  Diet and serum cholersterol levels. A comparision between vegetarians and nonvegetarians in a Seventh-day Adventist group. , 1968, The American journal of clinical nutrition.

[116]  I. Bross,et al.  Cancer and coronary artery disease among seventh‐day adventists , 1959, Cancer.

[117]  R. Masironi Dietary factors and coronary heart disease. , 1970, Bulletin of the World Health Organization.

[118]  S. Rinzler,et al.  Primary prevention of coronary heart disease by diet. , 1967, American heart journal.

[119]  G. Glober,et al.  Fecal bile acids in two Japanese populations with different colon cancer risks. , 1979, Cancer research.

[120]  S. Grundy,et al.  Influence of polyunsaturated fats on composition of plasma lipoproteins and apolipoproteins. , 1982, Journal of lipid research.

[121]  J. Farquhar,et al.  Carbohydrate-induced and fat-induced lipemia. , 1961, Transactions of the Association of American Physicians.

[122]  S. Grundy,et al.  Effects of polyunsaturated fats on lipid metabolism in patients with hypertriglyceridemia. , 1975, The Journal of clinical investigation.

[123]  R. Havel,et al.  Mathematical evaluation of methods for estimation of the concentration of the major lipid components of human serum lipoproteins. , 1976, The Journal of laboratory and clinical medicine.

[124]  N. Jolliffe,et al.  Statistical associations between international coronary heart disease death rates and certain environmental factors. , 1959, Journal of chronic diseases.

[125]  H. Mcgill,et al.  Experimental atherosclerosis in the baboon. , 1976, Primates in medicine.

[126]  Ancel Keys Coronary heart disease in seven countries. , 1971, The Medical journal of Australia.

[127]  F. Cambien,et al.  Total serum cholesterol and cancer mortality in a middle-aged male population. , 1980, American journal of epidemiology.

[128]  S. Syme,et al.  Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: prevalence of coronary and hypertensive heart disease and associated risk factors. , 1975, American journal of epidemiology.

[129]  M. Brown,et al.  Familial hypercholesterolemia: A genetic defect in the low-density lipoprotein receptor. , 1976, The New England journal of medicine.

[130]  C. Chapman,et al.  The relation in man between cholesterol levels in the diet and in the blood. , 1950, Science.

[131]  U. Tomiyasu,et al.  A Controlled Clinical Trial of a Diet High in Unsaturated Fat in Preventing Complications of Atherosclerosis , 1969 .

[132]  E. L. Wynder,et al.  Cancer, coronary artery disease and smoking: a preliminary report on differences in incidence between Seventh-day Adventists and others. , 1958, California medicine.

[133]  D. S. Lin,et al.  The intestinal absorption of dietary cholesterol by hypercholesterolemic (type II) and normocholesterolemic humans. , 1974, The Journal of clinical investigation.

[134]  A. Motulsky,et al.  Myocardial infarction in the familial forms of hypertriglyceridemia. , 1976, Metabolism: clinical and experimental.

[135]  A. Spector,et al.  Effect of specific fatty acyl enrichments on membrane physical properties detected with a spin label probe. , 1978, The Journal of biological chemistry.

[136]  A. Siegelaub,et al.  Kaiser-Permanente epidemiologic study of myocardial infarction. Study design and results for standard risk factors. , 1974, American journal of epidemiology.

[137]  J. Stamler,et al.  Effectiveness of a low saturated fat, low cholesterol, weight-reducing diet for the control of hypertriglyyceridemia. , 1972, Atherosclerosis.

[138]  T. Dawber,et al.  The Yugoslavia cardiovascular disease study. II. Factors in the incidence of coronary heart disease. , 1976, American journal of epidemiology.