Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion

[1]  Dirce Maria Carraro,et al.  Predictive models for mutations in mismatch repair genes: implication for genetic counseling in developing countries , 2012, BMC Cancer.

[2]  J. Mpindi,et al.  A cell spot microarray method for production of high density siRNA transfection microarrays , 2011, BMC Genomics.

[3]  K. Kleivi,et al.  Integrative functional genomics analysis of sustained polyploidy phenotypes in breast cancer cells identifies an oncogenic profile for GINS2. , 2010, Neoplasia.

[4]  W. Gerald,et al.  Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development , 2010, Cancer Epidemiology, Biomarkers & Prevention.

[5]  C. Sander,et al.  Integrative genomic profiling of human prostate cancer. , 2010, Cancer cell.

[6]  P. Dorrestein,et al.  PHF8 Mediates Histone H4 Lysine 20 Demethylation Events Involved in Cell Cycle Progression , 2010, Nature.

[7]  Manolis Kellis,et al.  Discovery and characterization of chromatin states for systematic annotation of the human genome , 2010, Nature Biotechnology.

[8]  D. B. Gordon,et al.  The XLMR gene PHF8 encodes a histone H4K20/H3K9 demethylase and regulates zebrafish brain and craniofacial development , 2010, Nature.

[9]  Xiang Wang,et al.  PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis , 2010, Cell Research.

[10]  Jyrki Lötjönen,et al.  A Comprehensive Panel of Three-Dimensional Models for Studies of Prostate Cancer Growth, Invasion and Drug Responses , 2010, PloS one.

[11]  R. Shiekhattar,et al.  PHF8 Targets Histone Methylation and RNA Polymerase II To Activate Transcription , 2010, Molecular and Cellular Biology.

[12]  Juri Rappsilber,et al.  A Functional Link between the Histone Demethylase PHF8 and the Transcription Factor ZNF711 in X-Linked Mental Retardation , 2010, Molecular cell.

[13]  T. Jenuwein,et al.  PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation , 2010, Nature Structural &Molecular Biology.

[14]  V. Flamand,et al.  Targeting monoamine oxidase A in advanced prostate cancer , 2010, Journal of Cancer Research and Clinical Oncology.

[15]  Q. Schiermeier.  IPCC flooded by criticism , 2010, Nature.

[16]  A. Abbott.  Project set to map marks on genome , 2010, Nature.

[17]  R. Klose,et al.  PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an N-dimethyl lysine demethylase , 2009 .

[18]  R. Büttner,et al.  Global levels of histone modifications predict prostate cancer recurrence , 2010, The Prostate.

[19]  Herbert J Zeh,et al.  High-mobility group box 1 and cancer. , 2010, Biochimica et biophysica acta.

[20]  Yang Shi,et al.  Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases , 2010, Nature Structural &Molecular Biology.

[21]  Peter A. Jones,et al.  Epigenetics in cancer. , 2010, Carcinogenesis.

[22]  Aideen Long,et al.  Statistical methods for analysis of high-throughput RNA interference screens , 2009, Nature Methods.

[23]  C. Gahmberg,et al.  PKCɛ Regulation of an α5 Integrin–ZO-1 Complex Controls Lamellae Formation in Migrating Cancer Cells , 2009, Science Signaling.

[24]  Ricky W. Johnstone,et al.  Epigenetics in cancer: Targeting chromatin modifications , 2009, Molecular Cancer Therapeutics.

[25]  S. Horvath,et al.  Global levels of histone modifications predict prognosis in different cancers. , 2009, The American journal of pathology.

[26]  L. Borsu,et al.  Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer. , 2009, Cancer research.

[27]  C. Cooper,et al.  Concepts of epigenetics in prostate cancer development , 2008, British Journal of Cancer.

[28]  O. Kallioniemi,et al.  Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG‐positive prostate cancer , 2008, International journal of cancer.

[29]  C. Allis,et al.  PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks. , 2008, Mutation research.

[30]  U. Oppermann,et al.  Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. , 2008, Journal of medicinal chemistry.

[31]  J. Astola,et al.  Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues , 2008, Genome Biology.

[32]  E. Rajcan-Separovic,et al.  Autism‐associated familial microdeletion of Xp11.22 , 2008, Clinical genetics.

[33]  Sabine S. Lange,et al.  High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage , 2008, Proceedings of the National Academy of Sciences.

[34]  W. Weichert,et al.  Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy , 2008, British Journal of Cancer.

[35]  R. Janknecht,et al.  Succinate inhibition of α-ketoglutarate-dependent enzymes in a yeast model of paraganglioma , 2007 .

[36]  C. Chen,et al.  JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer , 2007, Proceedings of the National Academy of Sciences.

[37]  Simon Tavaré,et al.  beadarray: R classes and methods for Illumina bead-based data , 2007, Bioinform..

[38]  R. Janknecht,et al.  Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D. , 2007, Biochemical and biophysical research communications.

[39]  A. Koivisto,et al.  Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate , 2007, Clinical genetics.

[40]  M. Miano,et al.  A novel mutation in the PHF8 gene is associated with X‐linked mental retardation with cleft lip/cleft palate , 2007, Clinical genetics.

[41]  S. Wolf,et al.  A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR. , 2007, Archives of biochemistry and biophysics.

[42]  T. Jenuwein,et al.  Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression , 2007, Nature Cell Biology.

[43]  Ian M. Fingerman,et al.  Proteome-wide Analysis in Saccharomyces cerevisiae Identifies Several PHD Fingers as Novel Direct and Selective Binding Modules of Histone H3 Methylated at Either Lysine 4 or Lysine 36* , 2007, Journal of Biological Chemistry.

[44]  C. Allis,et al.  Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. , 2007, Molecular cell.

[45]  R. Janknecht,et al.  Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma. , 2007, Human molecular genetics.

[46]  M. Becich,et al.  Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process , 2007, BMC Cancer.

[47]  R. Schüle,et al.  Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence. , 2006, Cancer research.

[48]  Juri Rappsilber,et al.  The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3 , 2006, Nature.

[49]  J. Mellor.  It Takes a PHD to Read the Histone Code , 2006, Cell.

[50]  Min Gyu Lee,et al.  Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. , 2006, Chemistry & biology.

[51]  Paul Tempst,et al.  JHDM2A, a JmjC-Containing H3K9 Demethylase, Facilitates Transcription Activation by Androgen Receptor , 2006, Cell.

[52]  S. Minucci,et al.  Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer , 2006, Nature Reviews Cancer.

[53]  C. Schwartz,et al.  Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate , 2005, Journal of Medical Genetics.

[54]  Antoine H. F. M. Peters,et al.  LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription , 2005, Nature.

[55]  S. Horvath,et al.  Global histone modification patterns predict risk of prostate cancer recurrence , 2005, Nature.

[56]  M. Fraga,et al.  Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer , 2005, Nature Genetics.

[57]  Wenjun Guo,et al.  Integrin signalling during tumour progression , 2004, Nature Reviews Molecular Cell Biology.

[58]  Peter A. Jones,et al.  Epigenetics in human disease and prospects for epigenetic therapy , 2004, Nature.

[59]  Hing Y Leung,et al.  Upregulation and Nuclear Recruitment of HDAC1 in Hormone Refractory Prostate Cancer , 2004, The Prostate.

[60]  Douglas A. Hosack,et al.  Identifying biological themes within lists of genes with EASE , 2003, Genome Biology.

[61]  Manel Esteller,et al.  Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. , 2003, Cancer research.