CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review

The review lays emphasis on the significance of 1,2,3-triazoles synthesized via CuAAC reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory, anti-tuberculosis, anti-diabetic, and anti-Alzheimer drugs. The importance of click chemistry is due to its ‘quicker’ methodology that has the capability to create complex and efficient drugs with high yield and purity from simple and cheap starting materials. The activity of different triazolyl compounds was compiled considering MIC, IC50, and EC50 values against different species of microbes. In addition to this, the anti-oxidant property of triazolyl compounds have also been reviewed and discussed.

[1]  Chao-Yun Cai,et al.  Design and synthesis of novel xanthone-triazole derivatives as potential antidiabetic agents: α-Glucosidase inhibition and glucose uptake promotion. , 2019, European journal of medicinal chemistry.

[2]  O. Firuzi,et al.  Click chemistry-assisted synthesis of novel aminonaphthoquinone-1,2,3-triazole hybrids and investigation of their cytotoxicity and cancer cell cycle alterations. , 2019, Bioorganic chemistry.

[3]  N. Singhal,et al.  Multi-target-directed triazole derivatives as promising agents for the treatment of Alzheimer's disease. , 2019, Bioorganic chemistry.

[4]  Liwen Han,et al.  Novel carbohydrate modified berberine derivatives: synthesis and in vitro anti-diabetic investigation. , 2019, MedChemComm.

[5]  D. Piotrowska,et al.  Synthesis and antimicrobial activity of novel 1,2,3‐triazole‐conjugates of quinazolin‐4‐ones , 2019, Archiv der Pharmazie.

[6]  Reza Ghadimi,et al.  Design and synthesis of novel quinazolinone-1,2,3-triazole hybrids as new anti-diabetic agents: In vitro α-glucosidase inhibition, kinetic, and docking study. , 2019, Bioorganic chemistry.

[7]  B. Larijani,et al.  Design, synthesis and anti-Alzheimer's activity of novel 1,2,3-triazole-chromenone carboxamide derivatives. , 2019, Bioorganic chemistry.

[8]  Y. Cordeiro,et al.  Design, synthesis, structural characterization and in vitro evaluation of new 1,4-disubstituted-1,2,3-triazole derivatives against glioblastoma cells. , 2019, Bioorganic chemistry.

[9]  M. Sharifzadeh,et al.  Novel tacrine-coumarin hybrids linked to 1,2,3-triazole as anti-Alzheimer's compounds: In vitro and in vivo biological evaluation and docking study. , 2019, Bioorganic chemistry.

[10]  B. Larijani,et al.  Phthalimide-1,2,3-triazole hybrid compounds as tyrosinase inhibitors; synthesis, biological evaluation and molecular docking analysis , 2019, Journal of Molecular Structure.

[11]  B. Mandal,et al.  Design, Synthesis, Characterization, and Antiproliferative Activity of Organoplatinum Compounds Bearing a 1,2,3-Triazole Ring , 2019, ACS Omega.

[12]  D. Sriram,et al.  Synthesis and biological evaluation of 1H-pyrrolo[2,3-d]pyrimidine-1,2,3-triazole derivatives as novel anti-tubercular agents. , 2019, Bioorganic & medicinal chemistry letters.

[13]  Fan-hong Wu,et al.  Study on the green click-chemistry synthesis of 4-trifluoroacetyl-1,2,3-triazoles , 2018, Tetrahedron.

[14]  Z. Al-Abri,et al.  Synthesis of 1H-1,2,3-triazole derivatives as new α-glucosidase inhibitors and their molecular docking studies. , 2018, Bioorganic chemistry.

[15]  Naveen Mulakayala,et al.  1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: Their anti-proliferative & anti-inflammatory activity. , 2018, Bioorganic chemistry.

[16]  M. Pal,et al.  1,2,3-Triazole fused with pyridine/pyrimidine as new template for antimicrobial agents: Regioselective synthesis and identification of potent N-heteroarenes. , 2018, Bioorganic & medicinal chemistry letters.

[17]  A. Kamal,et al.  Imidazopyridine linked triazoles as tubulin inhibitors, effectively triggering apoptosis in lung cancer cell line. , 2018, Bioorganic chemistry.

[18]  Fangfang Zhang,et al.  Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library. , 2018, European journal of medicinal chemistry.

[19]  A. Dasgupta,et al.  Synthesis of 1,2,3-triazole linked 4(3H)-Quinazolinones as potent antibacterial agents against multidrug-resistant Staphylococcus aureus. , 2018, European journal of medicinal chemistry.

[20]  K. Gupta,et al.  Synthesis, characterization and antibacterial studies of schiff based 1,2,3-triazole bridged silatranes , 2018, Journal of Organometallic Chemistry.

[21]  Dong-mei Wu,et al.  Synthesis and anti-proliferative activity of allogibberic acid derivatives containing 1,2,3-triazole pharmacophore. , 2018, Bioorganic & medicinal chemistry letters.

[22]  G. Andrei,et al.  Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation. , 2018, European journal of medicinal chemistry.

[23]  Arunandan Kumar,et al.  Synthesis, crystal structure and antimicrobial potential of some fluorinated chalcone-1,2,3-triazole conjugates. , 2018, European journal of medicinal chemistry.

[24]  Anwita Mudiraj,et al.  Synthesis of pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered to 1,2,3-triazoles and their evaluation as potential anticancer agents. , 2018, European journal of medicinal chemistry.

[25]  M. Leist,et al.  Correlation of structural features of novel 1,2,3-triazoles with their neurotoxic and tumoricidal properties. , 2018, Chemico-biological interactions.

[26]  Sarbani Pal,et al.  Design, Synthesis and Antibacterial Evaluation of Compounds Based on New Benzoxepine-oxime-1,2,3-triazole Hybrid. , 2018, Mini reviews in medicinal chemistry.

[27]  E. De Clercq,et al.  Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus. , 2018, European journal of medicinal chemistry.

[28]  D. Sriram,et al.  1,2,3-Triazole-fused spirochromenes as potential anti-tubercular agents: synthesis and biological evaluation , 2018, RSC advances.

[29]  A. Prasad,et al.  Synthesis and antimycobacterial activity of 1-(β-d-Ribofuranosyl)-4-coumarinyloxymethyl- / -coumarinyl-1,2,3-triazole. , 2018, European journal of medicinal chemistry.

[30]  Arunandan Kumar,et al.  Design, synthesis, characterization, antimicrobial evaluation and molecular modeling studies of some dehydroacetic acid-chalcone-1,2,3-triazole hybrids. , 2018, Bioorganic chemistry.

[31]  R. S. Ferreira,et al.  Synthesis and leishmanicidal activity of eugenol derivatives bearing 1,2,3-triazole functionalities. , 2018, European journal of medicinal chemistry.

[32]  R. Leurs,et al.  Non-Imidazole Histamine H3 Ligands. Part VII. Synthesis, In Vitro and In Vivo Characterization of 5-Substituted-2-thiazol-4-n-propylpiperazines , 2018, Molecules.

[33]  M. Janeczko,et al.  Synthesis and Antimicrobial Activity of 4-Substituted 1,2,3-Triazole-Coumarin Derivatives , 2018, Molecules.

[34]  Gisbert Schneider,et al.  Automating drug discovery , 2017, Nature Reviews Drug Discovery.

[35]  O. Firuzi,et al.  Multifunctional iminochromene-2H-carboxamide derivatives containing different aminomethylene triazole with BACE1 inhibitory, neuroprotective and metal chelating properties targeting Alzheimer's disease. , 2017, European journal of medicinal chemistry.

[36]  Estari Mamidala,et al.  Synthesis, anticancer and antibacterial evaluation of novel (isopropylidene) uridine-[1,2,3]triazole hybrids , 2017 .

[37]  M. Choudhary,et al.  New carbazole linked 1,2,3-triazoles as highly potent non-sugar α-glucosidase inhibitors. , 2017, Bioorganic chemistry.

[38]  G. Rastelli,et al.  The 1,2,3-triazole ring as a bioisostere in medicinal chemistry. , 2017, Drug discovery today.

[39]  Zhi Xu,et al.  Triazole derivatives and their anti-tubercular activity. , 2017, European journal of medicinal chemistry.

[40]  B. Ruan,et al.  Click chemistry-based synthesis and anticancer activity evaluation of novel C-14 1,2,3-triazole dehydroabietic acid hybrids. , 2017, European journal of medicinal chemistry.

[41]  Chi-Ying F. Huang,et al.  Using gene expression database to uncover biology functions of 1,4-disubstituted 1,2,3-triazole analogues synthesized via a copper (I)-catalyzed reaction. , 2017, European journal of medicinal chemistry.

[42]  Cheryl L. Allen,et al.  Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase. , 2017, Bioorganic & medicinal chemistry.

[43]  Virender Singh,et al.  Medicinal attributes of 1,2,3-triazoles: Current developments. , 2017, Bioorganic chemistry.

[44]  Sarbani Pal,et al.  1,2,3-Triazole-nimesulide hybrid: Their design, synthesis and evaluation as potential anticancer agents. , 2017, Bioorganic & medicinal chemistry letters.

[45]  K. M. Fazili,et al.  Synthesis and biological evaluation of novel 3-O-tethered triazoles of diosgenin as potent antiproliferative agents , 2017, Steroids.

[46]  Y. Keum,et al.  Access to the substituted benzyl-1,2,3-triazolyl hesperetin derivatives expressing antioxidant and anticancer effects , 2017 .

[47]  Qiang Zhu,et al.  A one-pot synthesis of [1,2,3]triazolo[1,5-a]quinoxalines from 1-azido-2-isocyanoarenes with high bond-forming efficiency. , 2017, Chemical communications.

[48]  M. Sharifzadeh,et al.  Novel tacrine-1,2,3-triazole hybrids: In vitro, in vivo biological evaluation and docking study of cholinesterase inhibitors. , 2017, European journal of medicinal chemistry.

[49]  S. Kraljević Pavelić,et al.  Novel pyrimidine-2,4-dione-1,2,3-triazole and furo[2,3-d]pyrimidine-2-one-1,2,3-triazole hybrids as potential anti-cancer agents: Synthesis, computational and X-ray analysis and biological evaluation. , 2017, European journal of medicinal chemistry.

[50]  Yingjie Zhang,et al.  Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole "click" ligands. , 2016, Journal of inorganic biochemistry.

[51]  Guangcheng Wang,et al.  Synthesis and biological evaluation of novel 2,4,5-triarylimidazole-1,2,3-triazole derivatives via click chemistry as α-glucosidase inhibitors. , 2016, Bioorganic & medicinal chemistry letters.

[52]  K. Mukkanti,et al.  1H-1,2,3-Triazolyl-substituted 1,3,4-oxadiazole derivatives containing structural features of ibuprofen/naproxen: Their synthesis and antibacterial evaluation. , 2016, Bioorganic & medicinal chemistry letters.

[53]  P. Venkata Ramana,et al.  Synthesis, characterization and evaluation of antibacterial activity of (E)-N'-(substituted benzylidene)-2-(2-fluorobenzyl)-5-ethyl-2H-1,2,3-triazole-4-carbohydrazides. , 2016, Annales pharmaceutiques francaises.

[54]  Tariq M Rana,et al.  1,2,3-Triazoles as Amide Bioisosteres: Discovery of a New Class of Potent HIV-1 Vif Antagonists. , 2016, Journal of medicinal chemistry.

[55]  P. Sujitha,et al.  Ferrocenyl chalcogeno (sugar) triazole conjugates: Synthesis, characterization and anticancer properties , 2016 .

[56]  Ramandeep Singh,et al.  Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids. , 2016, European journal of medicinal chemistry.

[57]  F. Celik,et al.  Synthesis of Novel Symmetrical 1,4-Disubstituted 1,2,3-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation , 2016, Molecules.

[58]  P. Pathi,et al.  Synthesis, anti-inflammatory, bactericidal activities and docking studies of novel 1,2,3-triazoles derived from ibuprofen using click chemistry , 2016, SpringerPlus.

[59]  E. V. V. S. Ramarao,et al.  Assembly of Quinoline, Triazole and Oxime Ether in a Single Molecular Entity: A Greener and One-pot Synthesis of Novel Oximes as Potential Cytotoxic Agents , 2016 .

[60]  I. Tetko,et al.  Extended Functional Groups (EFG): An Efficient Set for Chemical Characterization and Structure-Activity Relationship Studies of Chemical Compounds , 2015, Molecules.

[61]  Tatjana Gazivoda Kraljević,et al.  1,2,3-Triazole pharmacophore-based benzofused nitrogen/sulfur heterocycles with potential anti-Moraxella catarrhalis activity. , 2015, Bioorganic & medicinal chemistry.

[62]  S. Joshi,et al.  A click chemistry approach for the synthesis of mono and bis aryloxy linked coumarinyl triazoles as anti-tubercular agents. , 2015, European journal of medicinal chemistry.

[63]  K. Mukkanti,et al.  1,2,3-Triazoles derived from olanzapine: their synthesis via an ultrasound assisted CuAAC method and evaluation as inhibitors of PDE4B , 2015 .

[64]  Sarbani Pal,et al.  Novel benzoxepine-1,2,3-triazole hybrids: synthesis and pharmacological evaluation as potential antibacterial and anticancer agents , 2015 .

[65]  R. Ummanni,et al.  Synthesis and evaluation of novel fluorinated pyrazolo-1,2,3-triazole hybrids as antimycobacterial agents. , 2015, Bioorganic & medicinal chemistry letters.

[66]  A. Hameed,et al.  Synthesis and In vitro Evaluation of Dibenzoazepine Triazole Derivatives: A Novel Class of Antileishmanial Agents , 2015 .

[67]  H. Saad,et al.  Click reaction based synthesis, antimicrobial, and cytotoxic activities of new 1,2,3-triazoles. , 2015, Bioorganic & medicinal chemistry letters.

[68]  J. Deschamps,et al.  Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands. , 2015, Bioorganic & medicinal chemistry.

[69]  J. Sangshetti,et al.  1,2,3-Triazole derivatives as antitubercular agents: synthesis, biological evaluation and molecular docking study , 2015 .

[70]  Anil Kumar,et al.  Click chemistry inspired synthesis of piperazine-triazole derivatives and evaluation of their antimicrobial activities , 2015, Medicinal Chemistry Research.

[71]  Liying Ma,et al.  Design and synthesis of novel 1,2,3-triazole-pyrimidine-urea hybrids as potential anticancer agents. , 2015, Bioorganic & medicinal chemistry letters.

[72]  Sarbani Pal,et al.  Design of new hybrid template by linking quinoline, triazole and dihydroquinoline pharmacophoric groups: A greener approach to novel polyazaheterocycles as cytotoxic agents. , 2015, Bioorganic & medicinal chemistry letters.

[73]  Vijjulatha Manga,et al.  Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles. , 2015, Bioorganic & medicinal chemistry letters.

[74]  Mukesh C. Sharma,et al.  A click chemistry strategy to synthesize geraniol-coupled 1,4-disubstituted 1,2,3-triazoles and exploration of their microbicidal and antioxidant potential with molecular docking profile , 2015, Medicinal Chemistry Research.

[75]  Ghada E. A. Awad,et al.  Ultrasound-assisted synthesis of novel 1,2,3-triazoles coupled diaryl sulfone moieties by the CuAAC reaction, and biological evaluation of them as antioxidant and antimicrobial agents. , 2014, European journal of medicinal chemistry.

[76]  J. Hah,et al.  Click approach to the discovery of 1,2,3-triazolylsalicylamides as potent Aurora kinase inhibitors. , 2014, Bioorganic & medicinal chemistry.

[77]  Beena,et al.  Synthesis of novel 1,2,3-triazole derivatives of isoniazid and their in vitro and in vivo antimycobacterial activity evaluation. , 2014, European journal of medicinal chemistry.

[78]  C. Policar,et al.  Luminescence modulations of rhenium tricarbonyl complexes induced by structural variations. , 2014, Inorganic chemistry.

[79]  K. Mukkanti,et al.  Synthesis of 2,2,4-trimethyl-1,2-dihydroquinolinyl substituted 1,2,3-triazole derivatives: their evaluation as potential PDE 4B inhibitors possessing cytotoxic properties against cancer cells. , 2014, Bioorganic chemistry.

[80]  G. Hegde,et al.  Click chemistry approach: regioselective one-pot synthesis of some new 8-trifluoromethylquinoline based 1,2,3-triazoles as potent antimicrobial agents. , 2014, European journal of medicinal chemistry.

[81]  J. C. Lopes,et al.  7-Chloroquinolinotriazoles: synthesis by the azide-alkyne cycloaddition click chemistry, antimalarial activity, cytotoxicity and SAR studies. , 2014, European journal of medicinal chemistry.

[82]  Zhi Li,et al.  Synthesis and biological evaluation of 4-(1,2,3-triazol-1-yl)coumarin derivatives as potential antitumor agents. , 2014, Bioorganic & medicinal chemistry letters.

[83]  B. Tekwani,et al.  Click chemistry decoration of amino sterols as promising strategy to developed new leishmanicidal drugs , 2014, Steroids.

[84]  K. Mukkanti,et al.  Zebrafish based strategy for the identification of a potential pharmacophore for apoptosis: a greener CuAAC approach for novel 1,2,3-triazoles derived from mefenamic acid , 2014 .

[85]  Sarbani Pal,et al.  Synthesis and biological evaluation of nimesulide based new class of triazole derivatives as potential PDE4B inhibitors against cancer cells. , 2013, Bioorganic & medicinal chemistry letters.

[86]  H. Koh,et al.  Construction of a Library of Arylpiperazinyl 1,2,3-Triazole Derivatives as Ligands for Dopamine D3/D4 Receptor , 2013 .

[87]  T. Storr,et al.  Synthesis, characterization, and biological studies of emissive rhenium–glutamine conjugates , 2013, JBIC Journal of Biological Inorganic Chemistry.

[88]  Hong-min Liu,et al.  Design, synthesis and antiproliferative activity studies of novel 1,2,3-triazole-dithiocarbamate-urea hybrids. , 2013, European journal of medicinal chemistry.

[89]  Sarbani Pal,et al.  A Remarkably Faster Approach Towards 1,2,3-Triazolyl Quinolines Via CuAAC in Water: Their Crystal Structure Analysis and Antibacterial Activities , 2013 .

[90]  Xiao-Jing Shi,et al.  Design and synthesis of novel 1,2,3-triazole-dithiocarbamate hybrids as potential anticancer agents. , 2013, European journal of medicinal chemistry.

[91]  Dariusz Matosiuk,et al.  Click chemistry for drug development and diverse chemical-biology applications. , 2013, Chemical reviews.

[92]  C. Tintori,et al.  Probing the binding site of abl tyrosine kinase using in situ click chemistry. , 2013, ACS medicinal chemistry letters.

[93]  A. Furlan,et al.  'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells. , 2012, Bioorganic & medicinal chemistry letters.

[94]  M. Kandeel,et al.  Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives , 2012, Scientia pharmaceutica.

[95]  E. Crespan,et al.  N‐[2‐Methyl‐5‐(triazol‐1‐yl)phenyl]pyrimidin‐2‐amine as a Scaffold for the Synthesis of Inhibitors of Bcr‐Abl , 2011, ChemMedChem.

[96]  V. Pore,et al.  Click chemistry: 1,2,3-triazoles as pharmacophores. , 2011, Chemistry, an Asian journal.

[97]  M. Totrov,et al.  Triazole-linked reduced amide isosteres: an approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors. , 2011, Bioorganic & medicinal chemistry letters.

[98]  P. Yogeeswari,et al.  Syntheses and biological evaluation of new triazole-spirochromone conjugates as inhibitors of Mycobacterium tuberculosis , 2011 .

[99]  Brent R. Martin,et al.  Click-generated triazole ureas as ultrapotent, in vivo-active serine hydrolase inhibitors , 2011, Nature chemical biology.

[100]  Kai Liu,et al.  Novel efficient anticancer agents and DNA-intercalators of 1,2,3-triazol-1,8-naphthalimides: design, synthesis, and biological activity , 2011 .

[101]  Cheng‐He Zhou,et al.  Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents. , 2011, Bioorganic & medicinal chemistry letters.

[102]  Cheng-He Zhou,et al.  Synthesis of novel sulfanilamide-derived 1,2,3-triazoles and their evaluation for antibacterial and antifungal activities. , 2010, European journal of medicinal chemistry.

[103]  A. Capelli,et al.  Exploration of the amine terminus in a novel series of 1,2,4-triazolo-3-yl-azabicyclo[3.1.0]hexanes as selective dopamine D3 receptor antagonists. , 2010, Journal of medicinal chemistry.

[104]  A. V. Adhikari,et al.  Design, synthesis and antimicrobial activities of some new quinoline derivatives carrying 1,2,3-triazole moiety. , 2010, European journal of medicinal chemistry.

[105]  Sharad K. Pasale,et al.  Synthesis and biological evaluation of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives via click chemistry approach. , 2010, European journal of medicinal chemistry.

[106]  C. Kaiser,et al.  Synthesis, biological activity, and molecular modeling studies of 1H-1,2,3-triazole derivatives of carbohydrates as alpha-glucosidases inhibitors. , 2010, Journal of medicinal chemistry.

[107]  S. Kent,et al.  A one-pot approach to neoglycopeptides using orthogonal native chemical ligation and click chemistry. , 2009, Organic letters.

[108]  Adam Byron,et al.  Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6 , 2009, Science Signaling.

[109]  P. Schmieder,et al.  Metal-free, regioselective triazole ligations that deliver locked cis peptide mimetics. , 2009, Angewandte Chemie.

[110]  S. Zographos,et al.  Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case , 2009 .

[111]  Debbie L Hay,et al.  Measurement of Phosphorylated Extracellular Signal–Regulated Kinase 1 and 2 in an Undergraduate Teaching Laboratory with ALPHAscreen Technology , 2009, Science Signaling.

[112]  C. Gill,et al.  Clubbed [1,2,3] triazoles by fluorine benzimidazole: a novel approach to H37Rv inhibitors as a potential treatment for tuberculosis. , 2008, Bioorganic & medicinal chemistry letters.

[113]  B. Torbett,et al.  A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant. , 2008, Journal of medicinal chemistry.

[114]  C. Hung,et al.  Synthesis and cytotoxic, anti-inflammatory, and anti-oxidant activities of 2',5'-dialkoxylchalcones as cancer chemopreventive agents. , 2008, Bioorganic & medicinal chemistry.

[115]  Heather B. Miller,et al.  Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation. , 2008, Bioorganic & medicinal chemistry letters.

[116]  Z. Guan,et al.  A convergent synthesis of new β-turn mimics by click chemistry , 2006 .

[117]  B. S. Holla,et al.  Synthesis of some novel pyrazolo[3,4-d]pyrimidine derivatives as potential antimicrobial agents. , 2006, Bioorganic & medicinal chemistry.

[118]  William Lindstrom,et al.  Inhibitors of HIV-1 protease by using in situ click chemistry. , 2006, Angewandte Chemie.

[119]  M. Ghadiri,et al.  Efficient route to C2 symmetric heterocyclic backbone modified cyclic peptides. , 2005, Organic letters.

[120]  David S Goodsell,et al.  1,2,3‐Triazole as a Peptide Surrogate in the Rapid Synthesis of HIV‐1 Protease Inhibitors , 2005, Chembiochem : a European journal of chemical biology.

[121]  M. Ghadiri,et al.  Heterocyclic Peptide Backbone Modifications in an α-Helical Coiled Coil , 2004 .

[122]  W. Dehaen,et al.  A microwave-assisted click chemistry synthesis of 1,4-disubstituted 1,2,3-triazoles via a copper(I)-catalyzed three-component reaction. , 2004, Organic letters.

[123]  H. Kolb,et al.  The growing impact of click chemistry on drug discovery. , 2003, Drug discovery today.

[124]  David S Goodsell,et al.  Rapid Diversity‐Oriented Synthesis in Microtiter Plates for In Situ Screening of HIV Protease Inhibitors , 2003, Chembiochem : a European journal of chemical biology.

[125]  M. G. Finn,et al.  Click Chemistry: Diverse Chemical Function from a Few Good Reactions. , 2001, Angewandte Chemie.

[126]  M. Mastouri,et al.  One-pot four-component domino strategy for the synthesis of novel spirooxindole–pyrrolidine/pyrrolizidine-linked 1,2,3-triazole conjugates via stereo- and regioselective [3+2] cycloaddition reactions: In vitro antibacterial and antifungal studies , 2018 .