Initial clinical testing of a holographic non-invasive contact lens glucose sensor.

INTRODUCTION The purpose of the present study was to determine the effectiveness of a new holographic contact lens glucose sensor for the non-invasive monitoring of blood glucose. METHODS One fasting normal subject was given an oral challenge consisting of 44 g of glucose. The contact lens hologram signal and fingerstick blood glucose were measured over a 26- min period. RESULTS The contact lens hologram signal appeared to track blood glucose well. The contact lens was comfortable and well tolerated. CONCLUSION The holographic contact lens glucose sensor shows promise as a non-invasive home glucose monitor.

[1]  Peter Herbrechtsmeier,et al.  Clinical trial of a noninvasive contact lens glucose sensor. , 2004, Diabetes technology & therapeutics.

[2]  Jeff Blyth,et al.  Glucose-sensitive holographic sensors for monitoring bacterial growth. , 2004, Analytical chemistry.

[3]  J. Künzler,et al.  High-strength hydrogels based on N-vinyl pyrrolidinone and 4-t-butyl-2-hydroxycyclohexylmethacrylate. , 1992, Journal of biomedical materials research.

[4]  Jerome S. Schultz,et al.  Competitive-binding assay method based on fluorescence quenching of ligands held in close proximity by a multivalent receptor , 1997 .

[5]  John O. Edwards,et al.  Polyol Complexes and Structure of the Benzeneboronate Ion , 1959 .

[6]  Jeff Blyth,et al.  Holographic glucose sensors. , 2005, Biosensors & bioelectronics.

[7]  W. March.  Dealing with the delay. , 2002, Diabetes technology & therapeutics.

[8]  G L Coté,et al.  A fluorescence-based glucose biosensor using concanavalin A and dextran encapsulated in a poly(ethylene glycol) hydrogel. , 1999, Analytical chemistry.

[9]  J. Blyth,et al.  Glucose‐sensitive holographic sensors , 2004, Journal of molecular recognition : JMR.

[10]  W. March,et al.  Intraocular lens glucose sensor. , 2000, Diabetes technology & therapeutics.

[11]  W. March,et al.  Noninvasive Glucose Monitoring of the Aqueous Humor of the Eye: Part II. Animal Studies and the Scleral Lens , 1982, Diabetes Care.

[12]  Jeff Blyth,et al.  pH-sensitive holographic sensors. , 2003, Analytical chemistry.

[13]  Bill Long,et al.  Safety of contact lenses in patients with diabetes. , 2004, Diabetes technology & therapeutics.