Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

[1]  F. Sánchez‐Madrid,et al.  ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins , 2016, Nature Communications.

[2]  X. Wang,et al.  Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression. , 2016, Cancer cell.

[3]  Kei-Hoi Cheung,et al.  Extending gene ontology in the context of extracellular RNA and vesicle communication , 2016, Journal of biomedical semantics.

[4]  J. Lupski,et al.  Mechanisms underlying structural variant formation in genomic disorders , 2016, Nature Reviews Genetics.

[5]  Raghu Kalluri,et al.  The biology and function of exosomes in cancer. , 2016, The Journal of clinical investigation.

[6]  Clotilde Théry,et al.  Communication by Extracellular Vesicles: Where We Are and Where We Need to Go , 2016, Cell.

[7]  T. Wurdinger,et al.  Sensing of latent EBV infection through exosomal transfer of 5′pppRNA , 2016, Proceedings of the National Academy of Sciences.

[8]  Jun Yao,et al.  Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth , 2015, Nature.

[9]  Elizabeth E Gray,et al.  DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway , 2015, Science.

[10]  Gary K. Schwartz,et al.  Tumour exosome integrins determine organotropic metastasis , 2015, Nature.

[11]  Y. Miao,et al.  A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion , 2015, Cell.

[12]  Michael A. Hollingsworth,et al.  Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver , 2015, Nature Cell Biology.

[13]  D. C. Hancks,et al.  cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection , 2015, Proceedings of the National Academy of Sciences.

[14]  A. Kröger,et al.  DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity. , 2015, Immunity.

[15]  M. Nanjundan,et al.  Induction of PLSCR1 in a STING/IRF3-Dependent Manner upon Vector Transfection in Ovarian Epithelial Cells , 2015, PloS one.

[16]  Yong Cheng,et al.  Exosomes and other extracellular vesicles in host–pathogen interactions , 2015, EMBO reports.

[17]  K. Liestøl,et al.  ALIX and ESCRT-III Coordinately Control Cytokinetic Abscission during Germline Stem Cell Division In Vivo , 2015, PLoS genetics.

[18]  J. Hoeijmakers,et al.  An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. , 2014, Developmental cell.

[19]  J. Campisi,et al.  Senescence and apoptosis: dueling or complementary cell fates? , 2014, EMBO reports.

[20]  N. Hacohen,et al.  Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy. , 2014, Cell reports.

[21]  K. Naka,et al.  Crosstalk between the Rb pathway and AKT signaling forms a quiescence-senescence switch. , 2014, Cell reports.

[22]  Lynda Chin,et al.  Identification of Double-stranded Genomic DNA Spanning All Chromosomes with Mutated KRAS and p53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer* , 2014, The Journal of Biological Chemistry.

[23]  J. Sharpe,et al.  Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning , 2013, Cell.

[24]  A. Rodríguez-Baeza,et al.  Programmed Cell Senescence during Mammalian Embryonic Development , 2013, Cell.

[25]  K. Alitalo,et al.  A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. , 2013, Cancer cell.

[26]  Jiangxia Liu,et al.  Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity , 2013, Nature Immunology.

[27]  Peter D. Adams,et al.  Lysosome-mediated processing of chromatin in senescence , 2013, The Journal of cell biology.

[28]  Masahira Hattori,et al.  Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome , 2013, Nature.

[29]  H. Gunawardena,et al.  Modulation of B-cell exosome proteins by gamma herpesvirus infection , 2013, Proceedings of the National Academy of Sciences.

[30]  H. Kimura,et al.  Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway , 2013, Nature Structural &Molecular Biology.

[31]  G. Barber,et al.  STING recognition of cytoplasmic DNA instigates cellular defense. , 2013, Molecular cell.

[32]  Graça Raposo,et al.  Extracellular vesicles: Exosomes, microvesicles, and friends , 2013, The Journal of cell biology.

[33]  C. Harding,et al.  Exosomes: Looking back three decades and into the future , 2013, The Journal of cell biology.

[34]  Zhijian J. Chen,et al.  Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway , 2013, Science.

[35]  Lynne T. Bemis,et al.  Standardization of sample collection, isolation and analysis methods in extracellular vesicle research , 2013, Journal of extracellular vesicles.

[36]  Ylva Ivarsson,et al.  Syndecan–syntenin–ALIX regulates the biogenesis of exosomes , 2012, Nature Cell Biology.

[37]  Gema Moreno-Bueno,et al.  Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET , 2012, Nature Medicine.

[38]  G. Peters,et al.  DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells. , 2012, Molecular cell.

[39]  J. Lötvall,et al.  Isolation and Characterization of RNA-Containing Exosomes , 2012, Journal of visualized experiments : JoVE.

[40]  J. Campisi,et al.  Four faces of cellular senescence , 2011, The Journal of cell biology.

[41]  S. Pomeroy,et al.  Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. , 2011, Nature communications.

[42]  D. Peeper,et al.  The essence of senescence. , 2010, Genes & development.

[43]  Y. Matsuki,et al.  Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells*♦ , 2010, The Journal of Biological Chemistry.

[44]  T. Darville,et al.  Stimulator of IFN Gene Is Critical for Induction of IFN-β during Chlamydia muridarum Infection , 2010, The Journal of Immunology.

[45]  Miguel C. Seabra,et al.  Rab27a and Rab27b control different steps of the exosome secretion pathway , 2010, Nature Cell Biology.

[46]  M. Serrano,et al.  Senescence in tumours: evidence from mice and humans , 2010, Nature Reviews Cancer.

[47]  G. Barber,et al.  STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity , 2009, Nature.

[48]  H. Saya,et al.  Real-time in vivo imaging of p16Ink4a reveals cross talk with p53 , 2009, The Journal of cell biology.

[49]  Judith Campisi,et al.  Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor , 2008, PLoS biology.

[50]  R. Simpson,et al.  Proteomic profiling of exosomes: Current perspectives , 2008, Proteomics.

[51]  D. Terrian,et al.  Senescence-associated exosome release from human prostate cancer cells. , 2008, Cancer research.

[52]  D. Peeper,et al.  Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network , 2008, Cell.

[53]  Jonathan Melamed,et al.  Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence , 2008, Cell.

[54]  Petra Schwille,et al.  Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes , 2008, Science.

[55]  H. Saya,et al.  Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals , 2007, Proceedings of the National Academy of Sciences.

[56]  J. Campisi,et al.  Cellular senescence: when bad things happen to good cells , 2007, Nature Reviews Molecular Cell Biology.

[57]  J. Lötvall,et al.  Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells , 2007, Nature Cell Biology.

[58]  H. Saya,et al.  Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence , 2006, Nature Cell Biology.

[59]  Frédérick A. Mallette,et al.  DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation. , 2006, Molecular biology of the cell.

[60]  Aled Clayton,et al.  Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids , 2006, Current protocols in cell biology.

[61]  H. Yoshida,et al.  Lethal anemia caused by interferon-β produced in mouse embryos carrying undigested DNA , 2005, Nature Immunology.

[62]  R. Agami,et al.  The tumor-suppressive functions of the human INK4A locus. , 2003, Cancer cell.

[63]  Masashi Narita,et al.  Reversal of human cellular senescence: roles of the p53 and p16 pathways , 2003, The EMBO journal.

[64]  Wesley I. Sundquist,et al.  Tsg101 and the Vacuolar Protein Sorting Pathway Are Essential for HIV-1 Budding , 2001, Cell.

[65]  S. Nagata,et al.  Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. , 2001, Science.

[66]  G. Peters,et al.  Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence , 2001, Nature.

[67]  Dexi Liu,et al.  Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA , 1999, Gene Therapy.

[68]  G. Hannon,et al.  MaRX: An Approach to Genetics in Mammalian Cells , 1999, Science.

[69]  S. Lowe,et al.  Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a , 1997, Cell.