Several metal chalcogenides (e.g., ZnS, CdSe/ZnS) are known to be highly efficient scintillators. Concerns related to the use of these commercially available inorganic compounds (particle size: μm) include their low solubilities in organic and polymeric matrices. Their preparation in inorganic matrices, such as sol‐gels, results in non‐transparent gels, thus lowering their efficiency as scintillating devices. By reducing their particle sizes from commonly used micrometer‐ into nanometer‐size regimes, their optical properties and solubilities in both polar and nonpolar solvents can be controlled. The combination of sol‐gel technique and the chemistry of inorganic nanocrystalline quantum dots will be demonstrated as a powerful method in preparing scintillating devices.