论文信息 - Microelectrod fabrication for diagnosis and treatment of brain disorders

Microelectrod fabrication for diagnosis and treatment of brain disorders

In this study, it is aimed to produce microelectrodes which can be used in the detection of neurotransmitters that are related with brain disorders such as Parkinson, Epilepsy, and Schizophrenia and that exist in the central nervous system (CNS). A 4-channel, ceramic-based fabrication is performed towards this goal by using photolithographic methods. The time-current graphic response against the addition of H2O2 the produced microelectrode is analyzed in the calibration test. It is observed that the response is in stepwise form. In addition, limit of detection (LOD) of the produced microelectrodes and linearity values are shown to be within the desired ranges.

[1] Gergely Marton,et al. In Vivo Measurements With Robust Silicon-Based Multielectrode Arrays With Extreme Shaft Lengths , 2013, IEEE Sensors Journal.

[2] Francois Pomerleau,et al. Improved ceramic-based multisite microelectrode for rapid measurements of l-glutamate in the CNS , 2002, Journal of Neuroscience Methods.

[3] Sung June Kim,et al. A micromachined silicon depth probe for multichannel neural recording , 2000, IEEE Transactions on Biomedical Engineering.

[4] G. Gerhardt,et al. Self-referencing ceramic-based multisite microelectrodes for the detection and elimination of interferences from the measurement of L-glutamate and other analytes. , 2001, Analytical chemistry.

[5] K. Moxon,et al. Ceramic-based multisite microelectrodes for electrochemical recordings. , 2000, Analytical chemistry.

[6] G. Gerhardt,et al. Ceramic-based multisite microelectrode array for rapid choline measures in brain tissue , 2003 .