Syncrip/hnRNP Q is required for activity-induced Msp300/Nesprin-1 expression and new synapse formation

Local mRNA translation in neurons at a distance from the nucleus is key to new synapse formation. Titlow et al. find that the Syncrip RNA binding protein acts directly on msp300 mRNA to modulate activity-dependent synaptic plasticity. Single-molecule imaging reveals an activity-dependent increase in mRNP complex size and colocalization with ribosomes and the translation initiation factor eIF4E at the synapse.

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