NAC selectively inhibit cancer telomerase activity: A higher redox homeostasis threshold exists in cancer cells

[1]  N. Chandel,et al.  ROS-dependent signal transduction. , 2015, Current opinion in cell biology.

[2]  Juhyun Song,et al.  Glutathione Suppresses Cerebral Infarct Volume and Cell Death after Ischemic Injury: Involvement of FOXO3 Inactivation and Bcl2 Expression , 2015, Oxidative medicine and cellular longevity.

[3]  N. Zarghami,et al.  Curcumin and silibinin inhibit telomerase expression in T47D human breast cancer cells. , 2013, Asian Pacific journal of cancer prevention : APJCP.

[4]  J. Chiu,et al.  Redox control of cell proliferation. , 2012, Trends in cell biology.

[5]  M. Wink,et al.  Antiproliferative effects of crocin in HepG2 cells by telomerase inhibition and hTERT down-regulation. , 2012, Asian Pacific journal of cancer prevention : APJCP.

[6]  S. Sheweita,et al.  Can dietary antioxidants reduce the incidence of brain tumors? , 2011, Current drug metabolism.

[7]  F. Xie,et al.  The role of cellular oxidative stress in regulating glycolysis energy metabolism in hepatoma cells , 2009, Molecular Cancer.

[8]  N. Denko,et al.  Hypoxia, HIF1 and glucose metabolism in the solid tumour , 2008, Nature Reviews Cancer.

[9]  S. Kane,et al.  The green tea polyphenol, epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells. , 2007, Biochemical and biophysical research communications.

[10]  P. Kruk,et al.  Vitamin E suppresses telomerase activity in ovarian cancer cells. , 2007, Cancer detection and prevention.

[11]  Y. Whang,et al.  The PTEN tumor suppressor inhibits telomerase activity in endometrial cancer cells by decreasing hTERT mRNA levels. , 2006, Gynecologic oncology.

[12]  M. McMahon,et al.  The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer. , 2006, Molecular cell.

[13]  M. Bakhanashvili,et al.  Imatinib mesylate (Gleevec) downregulates telomerase activity and inhibits proliferation in telomerase-expressing cell lines , 2005, British Journal of Cancer.

[14]  K. Yudoh,et al.  Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function , 2005, Arthritis research & therapy.

[15]  Keiji Suzuki,et al.  Relief of oxidative stress by ascorbic acid delays cellular senescence of normal human and Werner syndrome fibroblast cells. , 2003, Free radical biology & medicine.

[16]  Wei Lian,et al.  Redox stress regulates cell proliferation and apoptosis of human hepatoma through Akt protein phosphorylation , 2003, FEBS letters.

[17]  Shantao Liu,et al.  Reactive oxygen species stimulated human hepatoma cell proliferation via cross-talk between PI3-K/PKB and JNK signaling pathways. , 2002, Archives of biochemistry and biophysics.

[18]  C. Sawyers,et al.  The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.

[19]  Druin Burch.  Sandbank , 2001, The Lancet.

[20]  S. Do,et al.  Akt Protein Kinase Enhances Human Telomerase Activity through Phosphorylation of Telomerase Reverse Transcriptase Subunit* , 1999, The Journal of Biological Chemistry.

[21]  R. Reddel,et al.  Telomere maintenance mechanisms and cellular immortalization. , 1999, Current opinion in genetics & development.

[22]  E. Hiyama,et al.  Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. , 1998, Life sciences.

[23]  June Corwin,et al.  Telomerase Catalytic Subunit Homologs from Fission Yeast and Human , 1997 .

[24]  Jacqueline K. Barton,et al.  Oxidative DNA damage through long-range electron transfer , 1996, Nature.

[25]  et al.,et al.  The RNA component of human telomerase , 1995, Science.

[26]  C B Harley,et al.  Specific association of human telomerase activity with immortal cells and cancer. , 1994, Science.

[27]  G. Wong,et al.  Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor , 1989, Cell.

[28]  R. Hilf,et al.  A fluorometric method for determination of oxidized and reduced glutathione in tissues. , 1976, Analytical biochemistry.

[29]  Frank D. Gray,et al.  Hypoxia , 1964, The Yale Journal of Biology and Medicine.