IGF signaling defects as causes of growth failure and IUGR
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Wieland Kiess | H. Werner | W. Kiess | R. Pfäffle | Haim Werner | Jürgen Klammt | Roland Pfäffle | J. Klammt
[1] T. Yagi,et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 , 1994, Nature.
[2] C. Kahn,et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene , 1994, Nature.
[3] M. Savage,et al. Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. , 1996, The New England journal of medicine.
[4] R. Kucherlapati,et al. K-ras is an essential gene in the mouse with partial functional overlap with N-ras. , 1997, Genes & development.
[5] Stefano Fumagalli,et al. Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase , 1998, The EMBO journal.
[6] Tony Pawson,et al. Mammalian Grb2 Regulates Multiple Steps in Embryonic Development and Malignant Transformation , 1998, Cell.
[7] G. Shulman,et al. Disruption of IRS-2 causes type 2 diabetes in mice , 1998, Nature.
[8] J. Charron,et al. Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta , 1999, Current Biology.
[9] M. White,et al. Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling , 1999, Nature Genetics.
[10] J. Pouysségur,et al. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. , 1999, Science.
[11] Y. Matsuzawa,et al. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase , 1999, Nature Genetics.
[12] R. Nussbaum,et al. Proliferative Defect and Embryonic Lethality in Mice Homozygous for a Deletion in the p110α Subunit of Phosphoinositide 3-Kinase* , 1999, The Journal of Biological Chemistry.
[13] Daniel A. Pollard,et al. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α , 2000, Nature Genetics.
[14] T Pawson,et al. The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. , 2000, Genes & development.
[15] M. White,et al. [Letters to nature] , 1975, Nature.
[16] S. Aizawa,et al. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. , 2000, Diabetes.
[17] Y. Azuma,et al. Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. , 2000, The Journal of clinical investigation.
[18] D. Lowy,et al. The Sos1 and Sos2 Ras‐specific exchange factors: differences in placental expression and signaling properties , 2000, The EMBO journal.
[19] M. Holzenberger,et al. A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficit. , 2000, Endocrinology.
[20] R. Burcelin,et al. Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice , 2000, Nature.
[21] G. Shulman,et al. Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes. , 2001, Genes & development.
[22] E. Wagner,et al. Embryonic lethality and fetal liver apoptosis in mice lacking the c‐raf‐1 gene , 2001, The EMBO journal.
[23] Kohjiro Ueki,et al. Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[24] K. Kaestner,et al. Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ) , 2001 .
[25] M. Malumbres,et al. Targeted Genomic Disruption of H-ras and N-ras, Individually or in Combination, Reveals the Dispensability of Both Loci for Mouse Growth and Development , 2001, Molecular and Cellular Biology.
[26] I. Roninson,et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. , 2001, Genes & development.
[27] M. Birnbaum,et al. Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice* , 2001, The Journal of Biological Chemistry.
[28] T. Frayling,et al. Conflicting results on variation in the IGFI gene highlight methodological considerations in the design of genetic association studies , 2002, Diabetologia.
[29] Albert Hofman,et al. Association between genetic variation in the gene for insulin-like growth factor-l and low birthweight , 2002, The Lancet.
[30] K. Okkenhaug,et al. Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice , 2002, Science.
[31] M. Stoffel,et al. β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass , 2002, Nature Genetics.
[32] M. Tally,et al. Transforming Growth Factor‐β1 in Fetal Serum Correlates With Insulin‐like Growth Factor‐I and Fetal Growth , 2002 .
[33] A. Prescott,et al. Essential role of PDK1 in regulating cell size and development in mice , 2002, The EMBO journal.
[34] M. Tremblay,et al. Mek2 Is Dispensable for Mouse Growth and Development , 2003, Molecular and Cellular Biology.
[35] S. Meloche,et al. An essential function of the mitogen‐activated protein kinase Erk2 in mouse trophoblast development , 2003, EMBO reports.
[36] Martin Holzenberger,et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice , 2003, Nature.
[37] P. Strisciuglio,et al. A novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency , 2003, Journal of medical genetics.
[38] J. Dupont,et al. Biology of insulin-like growth factors in development. , 2003, Birth defects research. Part C, Embryo today : reviews.
[39] C. Lautier,et al. IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. , 2003, The New England journal of medicine.
[40] J. Stock,et al. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. , 2003, The Journal of clinical investigation.
[41] A. Fowden. The insulin-like growth factors and feto-placental growth. , 2003, Placenta.
[42] Brian A. Hemmings,et al. Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth* , 2003, Journal of Biological Chemistry.
[43] D. Alessi,et al. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia , 2003, The EMBO journal.
[44] Wayne A. Phillips,et al. Mutation of the PIK3CA Gene in Ovarian and Breast Cancer , 2004, Cancer Research.
[45] Hiroyuki Konishi,et al. The PIK3CA gene is mutated with high frequency in human breast cancers , 2004, Cancer biology & therapy.
[46] B. Manning. Balancing Akt with S6K , 2004, The Journal of cell biology.
[47] Johan Auwerx,et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity , 2004, Nature.
[48] Mark A. Hanson,et al. The developmental origins of the metabolic syndrome , 2004, Trends in Endocrinology & Metabolism.
[49] Stefano Fumagalli,et al. S6K1−/−/S6K2−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway , 2004, Molecular and Cellular Biology.
[50] C. Kahn,et al. p50α/p55α Phosphoinositide 3-Kinase Knockout Mice Exhibit Enhanced Insulin Sensitivity , 2004, Molecular and Cellular Biology.
[51] Kozo Nakamura,et al. Deficiency of Insulin Receptor Substrate‐1 Impairs Skeletal Growth Through Early Closure of Epiphyseal Cartilage , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[52] Simeon I. Taylor,et al. Clinical Course of Genetic Diseases of the Insulin Receptor (Type A and Rabson-Mendenhall Syndromes): A 30-Year Prospective , 2004, Medicine.
[53] D. Alessi,et al. The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development , 2004, Nature Immunology.
[54] Howard L McLeod,et al. PI3K/Akt/mTOR pathway as a target for cancer therapy , 2005, Anti-cancer drugs.
[55] I. Hisatome,et al. Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation. , 2005, The Journal of clinical endocrinology and metabolism.
[56] F. Tronche,et al. Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure. , 2005, The Biochemical journal.
[57] Jeroen J. Bax,et al. Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation. , 2005, The Journal of clinical endocrinology and metabolism.
[58] Yuval Dor,et al. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. , 2005, Genes & development.
[59] C. Taniguchi,et al. Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism. , 2005, The Journal of clinical investigation.
[60] J. Frahm,et al. Essential role of protein kinase Bγ (PKBγ/Akt3) in postnatal brain development but not in glucose homeostasis , 2005, Development.
[61] R. Giorgino,et al. Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling. , 2005, Endocrinology.
[62] T. Ludwig,et al. Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size , 2005, Molecular and Cellular Biology.
[63] Y. Le Marchand-Brustel,et al. Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. , 2005, Biochimie.
[64] F. Artunc,et al. Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse. , 2006, American journal of physiology. Gastrointestinal and liver physiology.
[65] P. Gluckman,et al. The Consequences of Being Born Small – An Adaptive Perspective , 2006, Hormone Research in Paediatrics.
[66] H. Werner,et al. The insulin-like growth factor-I receptor gene: a downstream target for oncogene and tumor suppressor action , 2006, Trends in Endocrinology & Metabolism.
[67] S. Ozanne,et al. Mechanisms by which poor early growth programs type-2 diabetes, obesity and the metabolic syndrome , 2006, Physiology & Behavior.
[68] J. Kratzsch,et al. Clinical and functional characteristics of the human Arg59Ter insulin-like growth factor i receptor (IGF1R) mutation: implications for a gene dosage effect of the human IGF1R. , 2006, The Journal of clinical endocrinology and metabolism.
[69] K. Ong. Size at Birth, Postnatal Growth and Risk of Obesity , 2006, Hormone Research in Paediatrics.
[70] J. Romijn,et al. A variable degree of intrauterine and postnatal growth retardation in a family with a missense mutation in the insulin-like growth factor I receptor. , 2006, The Journal of clinical endocrinology and metabolism.
[71] P. Backeljauw,et al. Treatment of Insulin-Like Growth Factor Deficiency with IGF-I: Studies in Humans , 2006, Hormone Research in Paediatrics.
[72] Roger Smith,et al. Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus. , 2006, Endocrine reviews.
[73] Y. Kido,et al. Ablation of PDK1 in pancreatic β cells induces diabetes as a result of loss of β cell mass , 2006, Nature Genetics.
[74] J. Wit,et al. Genetic Disorders in the Growth Hormone – Insulin-Like Growth Factor-I Axis , 2006, Hormone Research in Paediatrics.
[75] R. Memmott,et al. Handicapping the Race to Develop Inhibitors of the Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin Pathway , 2006, Clinical Cancer Research.
[76] Yuki Kawashima,et al. OR11-5 A FAMILY WITH SHORT STATURE BORN INTRAUTERINE GROWTH RETARDATION BEARING A NEW MISSENSE MUTATION AT α SUBUNIT OF IGF-I RECEPTOR (R431L) , 2006 .
[77] D. Leroith,et al. A familial insulin-like growth factor-I receptor mutant leads to short stature: clinical and biochemical characterization. , 2007, The Journal of clinical endocrinology and metabolism.
[78] V. Hwa,et al. Defects in growth hormone receptor signaling , 2007, Trends in Endocrinology & Metabolism.
[79] T. Powell,et al. Mammalian target of rapamycin in the human placenta regulates leucine transport and is down‐regulated in restricted fetal growth , 2007, The Journal of physiology.
[80] E. Reiter. Hormonal Treatment of Idiopathic Short Stature , 2007, Hormone Research in Paediatrics.
[81] P. Czernichow,et al. Small for gestational age: short stature and beyond. , 2007, Endocrine reviews.
[82] F. Giorgino,et al. The IGF-I signaling pathway. , 2007, Current pharmaceutical design.
[83] Tom R. Gaunt,et al. Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease , 2007, Human Genetics.
[84] R. Nussbaum,et al. Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase , 2002, Mammalian Genome.
[85] Spyro Mousses,et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer , 2007, Nature.
[86] B. Hallgrímsson,et al. Inactivation of Pten in Osteo‐Chondroprogenitor Cells Leads to Epiphyseal Growth Plate Abnormalities and Skeletal Overgrowth , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.